Acute intravenous versus chronic oral drug effects of verapamil on left ventricular diastolic function in patients with hypertrophic cardiomyopathyPOSMA, JL., BLANKSMA, PK., VAN DER WALL, E. & LIE, KI., Dec-1994, In : Journal of Cardiovascular Pharmacology. 24, 6, p. 969-973 5 p.
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The effects of acute intravenous (i.v.) versus long-term oral(p.o.) verapamil administration on diastolic function were studied in 20 patients with hypertrophic cardiomyopathy (HCM). We used a tip manometer catheter to record left ventricular pressure (LVP) tracings and a nuclear probe to measure LV volume changes. Infusion of verapamil resulted in an increase in time constant of relaxation (+15%, p <0.001); LV peak filling rate, heart rate (HR), and stiffness constant of the diastolic pressure-volume relation were unchanged. During 18-week p.o. verapamil treatment, HR decreased (-16%, p <0.0005) and the atrial contribution to LV filling decreased (-27%, p <0.05); other parameters differed significantly from baseline values. Results demonstrate that acute i.v. versus long-term p.o. verapamil administration have different effects on diastolic function in HCM.
|Number of pages||5|
|Journal||Journal of Cardiovascular Pharmacology|
|Publication status||Published - Dec-1994|
- VERAPAMIL, HYPERTROPHY, CARDIOMYOPATHY, DIASTOLE, EXERCISE TOLERANCE, FILLING DYNAMICS, SHORT-TERM, RELAXATION, DISEASE, IMPROVEMENT, EXTENT, PROBE