Publication

Acute intravenous versus chronic oral drug effects of verapamil on left ventricular diastolic function in patients with hypertrophic cardiomyopathy

POSMA, JL., BLANKSMA, PK., VAN DER WALL, E. & LIE, KI., Dec-1994, In : Journal of Cardiovascular Pharmacology. 24, 6, p. 969-973 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • JL POSMA
  • PK BLANKSMA
  • E VAN DER WALL
  • KI LIE

The effects of acute intravenous (i.v.) versus long-term oral(p.o.) verapamil administration on diastolic function were studied in 20 patients with hypertrophic cardiomyopathy (HCM). We used a tip manometer catheter to record left ventricular pressure (LVP) tracings and a nuclear probe to measure LV volume changes. Infusion of verapamil resulted in an increase in time constant of relaxation (+15%, p <0.001); LV peak filling rate, heart rate (HR), and stiffness constant of the diastolic pressure-volume relation were unchanged. During 18-week p.o. verapamil treatment, HR decreased (-16%, p <0.0005) and the atrial contribution to LV filling decreased (-27%, p <0.05); other parameters differed significantly from baseline values. Results demonstrate that acute i.v. versus long-term p.o. verapamil administration have different effects on diastolic function in HCM.

Original languageEnglish
Pages (from-to)969-973
Number of pages5
JournalJournal of Cardiovascular Pharmacology
Volume24
Issue number6
Publication statusPublished - Dec-1994

    Keywords

  • VERAPAMIL, HYPERTROPHY, CARDIOMYOPATHY, DIASTOLE, EXERCISE TOLERANCE, FILLING DYNAMICS, SHORT-TERM, RELAXATION, DISEASE, IMPROVEMENT, EXTENT, PROBE

ID: 6404715