Publication

Acute adverse events in cardiac MR imaging with gadolinium-based contrast agents: results from the European Society of Cardiovascular Radiology (ESCR) MRCT Registry in 72,839 patients

ESCR MRCT Registry Contributors, Uhlig, J., Luecke, C., Vliegenthart, R., Loewe, C., Grothoff, M., Schuster, A., Lurz, P., Jacquier, A., Francone, M., Zapf, A., Schuelke, C., Thomas, D., May, M. S., Bremerich, J., Lotz, J. & Gutberlet, M., Jul-2019, In : European Radiology. 29, 7, p. 3686-3695 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • ESCR MRCT Registry Contributors
  • Johannes Uhlig
  • Christian Luecke
  • Rozemarijn Vliegenthart
  • Christian Loewe
  • Matthias Grothoff
  • Andreas Schuster
  • Philipp Lurz
  • Alexis Jacquier
  • Marco Francone
  • Antonia Zapf
  • Christoph Schuelke
  • Daniel Thomas
  • Matthias Stefan May
  • Jens Bremerich
  • Joachim Lotz
  • Matthias Gutberlet

ObjectivesTo assess the incidence of acute adverse events (AAEs) in gadolinium-enhanced cardiac magnetic resonance (CMR) imaging.MethodsGadolinium-based contrast agent (GBCA)-enhanced CMR data from the multinational, multicenter European Society of Cardiovascular Radiology MRCT Registry was included. AAE severity was classified according to the American College of Radiology Manual on Contrast Media (mild, moderate, severe). Multivariable generalized linear mixed effect models were used to assess the likelihood of AAEs in various GBCA, adjusting for pharmacological stressor, main indications (i.e., suspected or known coronary artery disease or myocarditis), age, sex, and submitting center as a random effect.ResultsIn the study population of 72,839 GBCA-enhanced CMRs, a total of 260 AAEs were reported (0.36%), with a minority of severe AAEs (n=24, 0.033%). Allergic-like AAEs were less likely than physiologic AAEs (29% versus 71%). Patients without pharmacological stress imaging had a lower AAE rate (0.22%) compared to stress imaging (0.75%), with the highest AAE rates for regadenoson (2.95%). AAE rates also varied by GBCA subtype (overall p

Original languageEnglish
Pages (from-to)3686-3695
Number of pages10
JournalEuropean Radiology
Volume29
Issue number7
Publication statusPublished - Jul-2019

    Keywords

  • Adverse drug event, Gadolinium, Cardiac imaging techniques, MRI, GADOPENTETATE DIMEGLUMINE, SAFETY, EXPERIENCE, REGADENOSON, MEDIA, ADMINISTRATIONS, TOLERABILITY, FREQUENCY, SEVERITY

View graph of relations

Download statistics

No data available

ID: 93760764