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Activities of Daily Living and Quality of Life During Treatment With Neoadjuvant Chemoradiotherapy and After Surgery in Patients With Esophageal Cancer

Mohammad, N. H., De Rooij, S., Hulshof, M., Ruurda, J., Wijnhoven, B., Erdkamp, F., Sosef, M., Gisbertz, S., Henegouwen, M. V. B., Sprangers, M. & Van Laarhoven, H., 1-Nov-2016, In : Journal of Surgical Oncology. 114, 6, p. 684-690 7 p.

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  • Activities of Daily Living and Quality of Life During Treatment

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DOI

  • Nadia Haj Mohammad
  • Sophia De Rooij
  • Maarten Hulshof
  • Jelle Ruurda
  • Bas Wijnhoven
  • Frans Erdkamp
  • Meindert Sosef
  • Suzanne Gisbertz
  • Mark Van Berge Henegouwen
  • Mirjam Sprangers
  • Hanneke Van Laarhoven

Background and Objectives: Neoadjuvant chemoradiation (nCRT) followed by esophagectomy is a treatment with curative intent for resectable esophageal cancer. The aim of this study was to measure activities of daily living (ADL) and quality of life (QoL), and to examine correlates of changes in ADL and QoL.

Methods: A prospective study was performed with three time points (baseline, 1 week after the end of nCRT, 3-months post-surgery) together with a cross-sectional post-treatment study. ADL was measured with the Amsterdam Linear Disability Score (ALDS), and QoL with the EORTC QLQC-30 and the OES-18. Regression analysis was performed to identify factors associated with changes in ADL and QoL.

Results: Seventy-six patients were included in the prospective study, 79 in the cross-sectional study. After nCRT, ALDS decreased from 90 to 88 (P

Conclusions: Patients who undergo nCRT plus surgery should be prepared to experience a short-term decline in ADL and QoL. The findings of this study can support patients and healthcare workers to guide expectations. (C) 2016 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)684-690
Number of pages7
JournalJournal of Surgical Oncology
Volume114
Issue number6
Publication statusPublished - 1-Nov-2016

    Keywords

  • esophageal cancer, quality of life, activities of daily living, neoadjuvant chemoradiotherapy, surgery, RANDOMIZED CONTROLLED-TRIAL, CLINICALLY RELEVANT, GERIATRIC ONCOLOGY, FUNCTIONAL DECLINE, JUNCTIONAL CANCER, CARCINOMA, PERFORMANCE, SURVIVORS, CHEMOTHERAPY, MULTICENTER

ID: 37619213