Publication

Action perception recruits the cerebellum and is impaired in patients with spinocerebellar ataxia

Abdelgabar, A. R., Suttrup, J., Broersen, R., Bhandari, R., Picard, S., Keysers, C., De Zeeuw, C. & Gazzola, V., Dec-2019, In : Brain. 142, p. 3791-3805 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Abdel R. Abdelgabar
  • Judith Suttrup
  • Robin Broersen
  • Ritu Bhandari
  • Samuel Picard
  • Christian Keysers
  • Chris De Zeeuw
  • Valeria Gazzola

Our cerebellum has been proposed to generate prediction signals that may help us plan and execute our motor programmes. However, to what extent our cerebellum is also actively involved in perceiving the action of others remains to be elucidated. Using functional MRI, we show here that observing goal-directed hand actions of others bilaterally recruits lobules VI, VIIb and VIIIa in the cerebellar hemispheres. Moreover, whereas healthy subjects (n = 31) were found to be able to discriminate subtle differences in the kinematics of observed limb movements of others, patients suffering from spinocerebellar ataxia type 6 (SCA6; n = 21) were severely impaired in performing such tasks. Our data suggest that the human cerebellum is actively involved in perceiving the kinematics of the hand actions of others and that SCA6 patients' deficits include a difficulty in perceiving the actions of other individuals. This finding alerts us to the fact that cerebellar disorders can alter social cognition.

Original languageEnglish
Pages (from-to)3791-3805
Number of pages15
JournalBrain
Volume142
Publication statusPublished - Dec-2019

    Keywords

  • spincocerebellar ataxia, cerebellar function, social cognition, imaging methodology, movement disorders, PRIMARY SOMATOSENSORY CORTEX, MIRROR NEURON SYSTEM, INFERIOR PARIETAL, MOTOR CORTEX, HAND ACTIONS, BRAIN, AREAS, LESIONS, FMRI, IMITATION

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