Publication

Accumulation of advanced glycation end products is associated with macrovascular events and glycaemic control with microvascular complications in Type 2 diabetes mellitus

Yozgatli, K., Lefrandt, J. D., Noordzij, M. J., Oomen, P. H. N., Brouwer, T., Jager, J., Cabezas, M. C. & Smit, A. J., Sep-2018, In : Diabetic Medicine. 35, 9, p. 1242-1248 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Yozgatli, K., Lefrandt, J. D., Noordzij, M. J., Oomen, P. H. N., Brouwer, T., Jager, J., ... Smit, A. J. (2018). Accumulation of advanced glycation end products is associated with macrovascular events and glycaemic control with microvascular complications in Type 2 diabetes mellitus. Diabetic Medicine, 35(9), 1242-1248. https://doi.org/10.1111/dme.13651

Author

Yozgatli, K. ; Lefrandt, J. D. ; Noordzij, M. J. ; Oomen, P. H. N. ; Brouwer, T. ; Jager, J. ; Cabezas, M. Castro ; Smit, A. J. / Accumulation of advanced glycation end products is associated with macrovascular events and glycaemic control with microvascular complications in Type 2 diabetes mellitus. In: Diabetic Medicine. 2018 ; Vol. 35, No. 9. pp. 1242-1248.

Harvard

Yozgatli, K, Lefrandt, JD, Noordzij, MJ, Oomen, PHN, Brouwer, T, Jager, J, Cabezas, MC & Smit, AJ 2018, 'Accumulation of advanced glycation end products is associated with macrovascular events and glycaemic control with microvascular complications in Type 2 diabetes mellitus', Diabetic Medicine, vol. 35, no. 9, pp. 1242-1248. https://doi.org/10.1111/dme.13651

Standard

Accumulation of advanced glycation end products is associated with macrovascular events and glycaemic control with microvascular complications in Type 2 diabetes mellitus. / Yozgatli, K.; Lefrandt, J. D.; Noordzij, M. J.; Oomen, P. H. N.; Brouwer, T.; Jager, J.; Cabezas, M. Castro; Smit, A. J.

In: Diabetic Medicine, Vol. 35, No. 9, 09.2018, p. 1242-1248.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Yozgatli K, Lefrandt JD, Noordzij MJ, Oomen PHN, Brouwer T, Jager J et al. Accumulation of advanced glycation end products is associated with macrovascular events and glycaemic control with microvascular complications in Type 2 diabetes mellitus. Diabetic Medicine. 2018 Sep;35(9):1242-1248. https://doi.org/10.1111/dme.13651


BibTeX

@article{84d5acf4a0574f599ed6420584824aa7,
title = "Accumulation of advanced glycation end products is associated with macrovascular events and glycaemic control with microvascular complications in Type 2 diabetes mellitus",
abstract = "AimThe United Kingdom Prospective Diabetes Study (UKPDS) study showed that glycaemic control (HbA(1c)) can predict vascular complications in Type 2 diabetes mellitus. The Diabetes Control and Complications Trial (DCCT) study showed that accumulation of advanced glycation end products (AGEs) from skin biopsies predicts vascular complications in Type 1 diabetes. Previously, we showed that tissue AGEs can be measured non-invasively using skin autofluorescence (SAF). The aim of this study was to compare the predictive value of HbA(1c) and SAF for new macrovascular events and microvascular complications in people with Type2 diabetes.MethodsA prospective cohort study of 563 participants, median age 64years [interquartile range (IQR) 57-72], diabetes duration of 13years, from five Dutch hospitals was performed.ResultsAfter a median follow-up of 5.1 (IQR 4.3-5.9)years, 79 (15{\%}) participants had died and 49 (9{\%}) were lost to follow-up. Some 133 (26{\%}) developed a microvascular complication and 189 (37{\%}) a macrovascular event. Tertiles of HbA(1c) were significantly associated with development of microvascular complications (log rank P=0.022), but not with macrovascular events. Tertiles of SAF were significantly associated with macrovascular events (log rank P=0.003). Cox regression analysis showed SAF was associated with macrovascular events: crude hazard ratio (HR) 1.53 (PConclusionThis study shows that tissue accumulation of AGEs, assessed by SAF, is associated with development of macrovascular events in people with Type2 diabetes, whereas HbA(1c) is associated with the development of microvascular complications.",
keywords = "SKIN AUTOFLUORESCENCE, VASCULAR COMPLICATIONS, RISK, TRIAL, MULTICENTER, PROGRESSION, DISEASE",
author = "K. Yozgatli and Lefrandt, {J. D.} and Noordzij, {M. J.} and Oomen, {P. H. N.} and T. Brouwer and J. Jager and Cabezas, {M. Castro} and Smit, {A. J.}",
year = "2018",
month = "9",
doi = "10.1111/dme.13651",
language = "English",
volume = "35",
pages = "1242--1248",
journal = "Diabetic Medicine",
issn = "0742-3071",
publisher = "Wiley",
number = "9",

}

RIS

TY - JOUR

T1 - Accumulation of advanced glycation end products is associated with macrovascular events and glycaemic control with microvascular complications in Type 2 diabetes mellitus

AU - Yozgatli, K.

AU - Lefrandt, J. D.

AU - Noordzij, M. J.

AU - Oomen, P. H. N.

AU - Brouwer, T.

AU - Jager, J.

AU - Cabezas, M. Castro

AU - Smit, A. J.

PY - 2018/9

Y1 - 2018/9

N2 - AimThe United Kingdom Prospective Diabetes Study (UKPDS) study showed that glycaemic control (HbA(1c)) can predict vascular complications in Type 2 diabetes mellitus. The Diabetes Control and Complications Trial (DCCT) study showed that accumulation of advanced glycation end products (AGEs) from skin biopsies predicts vascular complications in Type 1 diabetes. Previously, we showed that tissue AGEs can be measured non-invasively using skin autofluorescence (SAF). The aim of this study was to compare the predictive value of HbA(1c) and SAF for new macrovascular events and microvascular complications in people with Type2 diabetes.MethodsA prospective cohort study of 563 participants, median age 64years [interquartile range (IQR) 57-72], diabetes duration of 13years, from five Dutch hospitals was performed.ResultsAfter a median follow-up of 5.1 (IQR 4.3-5.9)years, 79 (15%) participants had died and 49 (9%) were lost to follow-up. Some 133 (26%) developed a microvascular complication and 189 (37%) a macrovascular event. Tertiles of HbA(1c) were significantly associated with development of microvascular complications (log rank P=0.022), but not with macrovascular events. Tertiles of SAF were significantly associated with macrovascular events (log rank P=0.003). Cox regression analysis showed SAF was associated with macrovascular events: crude hazard ratio (HR) 1.53 (PConclusionThis study shows that tissue accumulation of AGEs, assessed by SAF, is associated with development of macrovascular events in people with Type2 diabetes, whereas HbA(1c) is associated with the development of microvascular complications.

AB - AimThe United Kingdom Prospective Diabetes Study (UKPDS) study showed that glycaemic control (HbA(1c)) can predict vascular complications in Type 2 diabetes mellitus. The Diabetes Control and Complications Trial (DCCT) study showed that accumulation of advanced glycation end products (AGEs) from skin biopsies predicts vascular complications in Type 1 diabetes. Previously, we showed that tissue AGEs can be measured non-invasively using skin autofluorescence (SAF). The aim of this study was to compare the predictive value of HbA(1c) and SAF for new macrovascular events and microvascular complications in people with Type2 diabetes.MethodsA prospective cohort study of 563 participants, median age 64years [interquartile range (IQR) 57-72], diabetes duration of 13years, from five Dutch hospitals was performed.ResultsAfter a median follow-up of 5.1 (IQR 4.3-5.9)years, 79 (15%) participants had died and 49 (9%) were lost to follow-up. Some 133 (26%) developed a microvascular complication and 189 (37%) a macrovascular event. Tertiles of HbA(1c) were significantly associated with development of microvascular complications (log rank P=0.022), but not with macrovascular events. Tertiles of SAF were significantly associated with macrovascular events (log rank P=0.003). Cox regression analysis showed SAF was associated with macrovascular events: crude hazard ratio (HR) 1.53 (PConclusionThis study shows that tissue accumulation of AGEs, assessed by SAF, is associated with development of macrovascular events in people with Type2 diabetes, whereas HbA(1c) is associated with the development of microvascular complications.

KW - SKIN AUTOFLUORESCENCE

KW - VASCULAR COMPLICATIONS

KW - RISK

KW - TRIAL

KW - MULTICENTER

KW - PROGRESSION

KW - DISEASE

U2 - 10.1111/dme.13651

DO - 10.1111/dme.13651

M3 - Article

VL - 35

SP - 1242

EP - 1248

JO - Diabetic Medicine

JF - Diabetic Medicine

SN - 0742-3071

IS - 9

ER -

ID: 75920433