Publication

A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients: Should We Aim for Less?

Stolmeijer, R., Bouma, H. R., Zijlstra, J. G., Drost-de Klerck, A. M., ter Maaten, J. C. & Ligtenberg, J. J. M., 14-May-2018, In : Biomed Research International. 2018, p. 7841295 9 p., 7841295.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Stolmeijer, R., Bouma, H. R., Zijlstra, J. G., Drost-de Klerck, A. M., ter Maaten, J. C., & Ligtenberg, J. J. M. (2018). A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients: Should We Aim for Less? Biomed Research International, 2018, 7841295. [7841295]. https://doi.org/10.1155/2018/7841295

Author

Stolmeijer, R. ; Bouma, H. R. ; Zijlstra, J. G. ; Drost-de Klerck, A. M. ; ter Maaten, J. C. ; Ligtenberg, J. J. M. / A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients : Should We Aim for Less?. In: Biomed Research International. 2018 ; Vol. 2018. pp. 7841295.

Harvard

Stolmeijer, R, Bouma, HR, Zijlstra, JG, Drost-de Klerck, AM, ter Maaten, JC & Ligtenberg, JJM 2018, 'A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients: Should We Aim for Less?', Biomed Research International, vol. 2018, 7841295, pp. 7841295. https://doi.org/10.1155/2018/7841295

Standard

A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients : Should We Aim for Less? / Stolmeijer, R.; Bouma, H. R.; Zijlstra, J. G.; Drost-de Klerck, A. M.; ter Maaten, J. C.; Ligtenberg, J. J. M.

In: Biomed Research International, Vol. 2018, 7841295, 14.05.2018, p. 7841295.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Stolmeijer R, Bouma HR, Zijlstra JG, Drost-de Klerck AM, ter Maaten JC, Ligtenberg JJM. A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients: Should We Aim for Less? Biomed Research International. 2018 May 14;2018:7841295. 7841295. https://doi.org/10.1155/2018/7841295


BibTeX

@article{545da3d7d550435586dd213e31be165b,
title = "A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients: Should We Aim for Less?",
abstract = "Introduction. Despite widespread and liberal use of oxygen supplementation, guidelines about rational use of oxygen are scarce. Recent data demonstrates that current protocols lead to hyperoxemia in the majority of the patients and most health care professionals are not aware of the negative effects of hyperoxemia. Method. To investigate the effects of hyperoxemia in acutely ill patients on clinically relevant outcomes, such as neurological and functional status as well as mortality, we performed a literature review using Medline (PubMed) and Embase. We used the following terms: hyperoxemia OR hyperoxemia OR [{"}oxygen inhalation therapy{"} AND (mortality OR death OR outcome OR survival)] OR [oxygen AND (mortality OR death OR outcome OR survival)]. Original studies about the clinical effects of hyperoxemia in adult patients suffering from acute or emergency illnesses were included. Results. 37 articles were included, of which 31 could be divided into four large groups: cardiac arrest, traumatic brain injury (TBI), stroke, and sepsis. Although a single study demonstrated a transient protective effect of hyperoxemia after TBI, other studies revealed higher mortality rates after cardiac arrest, stroke, and TBI treated with oxygen supplementation leading to hyperoxemia. Approximately half of the studies showed no association between hyperoxemia and clinically relevant outcomes. Conclusion. Liberal oxygen therapy leads to hyperoxemia in a majority of patients and hyperoxemia may negatively affect survival after acute illness. As a clinical consequence, aiming for normoxemia may limit negative effects of hyperoxemia in patients with acute illness.",
keywords = "TRAUMATIC BRAIN-INJURY, HOSPITAL CARDIAC-ARREST, ACUTE ISCHEMIC-STROKE, NORMOBARIC OXYGEN-THERAPY, INTENSIVE-CARE-UNIT, MITOCHONDRIAL DYSFUNCTION, VENTILATED PATIENTS, SEPTIC SHOCK, ARTERIAL OXYGENATION, MULTICENTER COHORT",
author = "R. Stolmeijer and Bouma, {H. R.} and Zijlstra, {J. G.} and {Drost-de Klerck}, {A. M.} and {ter Maaten}, {J. C.} and Ligtenberg, {J. J. M.}",
year = "2018",
month = "5",
day = "14",
doi = "10.1155/2018/7841295",
language = "English",
volume = "2018",
pages = "7841295",
journal = "Biomed Research International",
issn = "2314-6133",
publisher = "HINDAWI LTD",

}

RIS

TY - JOUR

T1 - A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients

T2 - Should We Aim for Less?

AU - Stolmeijer, R.

AU - Bouma, H. R.

AU - Zijlstra, J. G.

AU - Drost-de Klerck, A. M.

AU - ter Maaten, J. C.

AU - Ligtenberg, J. J. M.

PY - 2018/5/14

Y1 - 2018/5/14

N2 - Introduction. Despite widespread and liberal use of oxygen supplementation, guidelines about rational use of oxygen are scarce. Recent data demonstrates that current protocols lead to hyperoxemia in the majority of the patients and most health care professionals are not aware of the negative effects of hyperoxemia. Method. To investigate the effects of hyperoxemia in acutely ill patients on clinically relevant outcomes, such as neurological and functional status as well as mortality, we performed a literature review using Medline (PubMed) and Embase. We used the following terms: hyperoxemia OR hyperoxemia OR ["oxygen inhalation therapy" AND (mortality OR death OR outcome OR survival)] OR [oxygen AND (mortality OR death OR outcome OR survival)]. Original studies about the clinical effects of hyperoxemia in adult patients suffering from acute or emergency illnesses were included. Results. 37 articles were included, of which 31 could be divided into four large groups: cardiac arrest, traumatic brain injury (TBI), stroke, and sepsis. Although a single study demonstrated a transient protective effect of hyperoxemia after TBI, other studies revealed higher mortality rates after cardiac arrest, stroke, and TBI treated with oxygen supplementation leading to hyperoxemia. Approximately half of the studies showed no association between hyperoxemia and clinically relevant outcomes. Conclusion. Liberal oxygen therapy leads to hyperoxemia in a majority of patients and hyperoxemia may negatively affect survival after acute illness. As a clinical consequence, aiming for normoxemia may limit negative effects of hyperoxemia in patients with acute illness.

AB - Introduction. Despite widespread and liberal use of oxygen supplementation, guidelines about rational use of oxygen are scarce. Recent data demonstrates that current protocols lead to hyperoxemia in the majority of the patients and most health care professionals are not aware of the negative effects of hyperoxemia. Method. To investigate the effects of hyperoxemia in acutely ill patients on clinically relevant outcomes, such as neurological and functional status as well as mortality, we performed a literature review using Medline (PubMed) and Embase. We used the following terms: hyperoxemia OR hyperoxemia OR ["oxygen inhalation therapy" AND (mortality OR death OR outcome OR survival)] OR [oxygen AND (mortality OR death OR outcome OR survival)]. Original studies about the clinical effects of hyperoxemia in adult patients suffering from acute or emergency illnesses were included. Results. 37 articles were included, of which 31 could be divided into four large groups: cardiac arrest, traumatic brain injury (TBI), stroke, and sepsis. Although a single study demonstrated a transient protective effect of hyperoxemia after TBI, other studies revealed higher mortality rates after cardiac arrest, stroke, and TBI treated with oxygen supplementation leading to hyperoxemia. Approximately half of the studies showed no association between hyperoxemia and clinically relevant outcomes. Conclusion. Liberal oxygen therapy leads to hyperoxemia in a majority of patients and hyperoxemia may negatively affect survival after acute illness. As a clinical consequence, aiming for normoxemia may limit negative effects of hyperoxemia in patients with acute illness.

KW - TRAUMATIC BRAIN-INJURY

KW - HOSPITAL CARDIAC-ARREST

KW - ACUTE ISCHEMIC-STROKE

KW - NORMOBARIC OXYGEN-THERAPY

KW - INTENSIVE-CARE-UNIT

KW - MITOCHONDRIAL DYSFUNCTION

KW - VENTILATED PATIENTS

KW - SEPTIC SHOCK

KW - ARTERIAL OXYGENATION

KW - MULTICENTER COHORT

U2 - 10.1155/2018/7841295

DO - 10.1155/2018/7841295

M3 - Review article

VL - 2018

SP - 7841295

JO - Biomed Research International

JF - Biomed Research International

SN - 2314-6133

M1 - 7841295

ER -

ID: 61486307