Publication

A Synthetic Receptor for Nicotine from a Dynamic Combinatorial Library

Hamieh, S., Ludlow, R. F., Perraud, O., West, K. R., Mattia, E. & Otto, S., 2-Nov-2012, In : Organic letters. 14, 21, p. 5404-5407 4 p.

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DOI

  • Saleh Hamieh
  • R. Frederick Ludlow
  • Olivier Perraud
  • Kevin R. West
  • Elio Mattia
  • Sijbren Otto

Designing synthetic receptors that bind biologically relevant guests in an aqueous solution remains a considerable challenge. We now report a new synthetic receptor for nicotine, selected from a dynamic combinatorial library, that binds this guest in water at neutral pH through a combination of hydrophobic and pi-pi a interactions.

Original languageEnglish
Pages (from-to)5404-5407
Number of pages4
JournalOrganic letters
Volume14
Issue number21
Publication statusPublished - 2-Nov-2012

    Keywords

  • CATION-PI INTERACTION, CHEMISTRY, BINDING, RECOGNITION

ID: 2307362