Publication

A polygenic risk score analysis of ASD and ADHD across emotion recognition subtypes

Waddington, F., Franke, B., Hartman, C., Buitelaar, J. K., Rommelse, N. & Mota, N. R., 20-Aug-2020, In : American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Francesca Waddington
  • Barbara Franke
  • Catharina Hartman
  • Jan K. Buitelaar
  • Nanda Rommelse
  • Nina Roth Mota

This study investigated the genetic components of ADHD and ASD by examining the cross-disorder trait of emotion recognition problems. The genetic burden for ADHD and ASD on previously identified emotion recognition factors (speed and accuracy of visual and auditory emotion recognition) and classes (Class 1: Average visual, impulsive auditory; Class 2: Average-strong visual & auditory; Class 3: Impulsive & imprecise visual, average auditory; Class 4: Weak visual & auditory) was assessed using ASD and ADHD polygenic risk scores (PRS). Our sample contained 552 participants: 74 with ADHD, 85 with ASD, 60 with ASD + ADHD, 177 unaffected siblings of ADHD or ASD probands, and 156 controls. ADHD- and ASD-PRS, calculated from the latest ADHD and ASD GWAS meta-analyses, were analyzed across these emotion recognition factors and classes using linear mixed models. Unexpectedly, the analysis of emotion recognition factors showed higher ASD-PRS to be associated with faster visual emotion recognition. The categorical analysis of emotion recognition classes showed ASD-PRS to be reduced in Class 3 compared to the other classes (p value threshold [pT] = 1, p = .021). A dimensional analysis identified a high ADHD-PRS reduced the probability of being assigned to the Class 1 or Class 3 (pT = .05, p = .028 and p = .044, respectively). Though these nominally significant results did not pass FDR correction, they potentially indicate different indirect causative chains from genetics via emotion recognition to ADHD and ASD, which need to be verified in future research.

Original languageEnglish
Number of pages11
JournalAmerican Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Publication statusE-pub ahead of print - 20-Aug-2020

    Keywords

  • ADHD, ASD, emotion recognition, polygenic risk score, subtyping, AUTISM SPECTRUM DISORDER, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, MENTAL-HEALTH, GENETIC RISK, CHILDREN, HYPERACTIVITY, PERSISTENCE, POPULATION

ID: 133218458