Publication

A Novel Approach to Drug Development in Heart Failure: Towards Personalized Medicine

Liu, L. C. Y., Voors, A. A., Valente, M. A. E. & van der Meer, P., Mar-2014, In : Canadian Journal of Cardiology. 30, 3, p. 288-295 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Evidence-based treatment has succeeded in improving clinical outcomes in heart failure. Nevertheless, morbidity, mortality, and the economic burden associated with the syndrome remain unsatisfactorily high. Most landmark heart failure studies included broad study populations, and thus current recommendations dictate standardized, universal therapy. While most patients included in recent trials benefit from this background treatment, exceeding this already significant gain has proven to be a challenge. The early identification of responders and nonresponders to treatment could result in improved therapeutic effectiveness, while reduction of unnecessary exposure may limit harmful and unpleasant side effects. In this review, we examine the potential value of currently available information on differential responses to heart failure therapy-a first step toward personalized medicine in the management of heart failure.

Original languageEnglish
Pages (from-to)288-295
Number of pages8
JournalCanadian Journal of Cardiology
Volume30
Issue number3
Early online date17-Dec-2013
Publication statusPublished - Mar-2014

    Keywords

  • PEPTIDE-GUIDED THERAPY, VENTRICULAR EJECTION FRACTION, ENZYME-INHIBITOR THERAPY, NATRIURETIC PEPTIDE, BETA(1)-ADRENERGIC RECEPTOR, ATRIAL-FIBRILLATION, DILATED CARDIOMYOPATHY, RETROSPECTIVE ANALYSIS, INDUCED CARDIOTOXICITY, DELETION POLYMORPHISM

ID: 15954565