A nanoLC-MS-based platform for peptide analysis

Rieux, L., 2006, s.n.. 185 p.

Research output: ThesisThesis fully internal (DIV)

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  • Laurent Rieux
In order to study the complex biochemical processes underlying pharmacological and medical events, sensitive and selective analytical methods are necessary. To this effect, we used a nanoLC-MS-based platform in order to perform analysis. The work presented in this thesis shows that in order to achieve the very high throughput and ease necessary in routine comparative proteomic studies, several limitations of nanoLC-MS such as low signal reproducibility, lengthy analysis times and poor system robustness have been overcome. Though much progress has been made generally in the field, nanoLC-MS is not yet a user-friendly technique and still requires dexterity. Nevertheless, the latest technological developments have started to make the use of nanoLC-MS more straightforward for inexperienced researchers.
Original languageEnglish
QualificationDoctor of Philosophy
Print ISBNs9036728150
Publication statusPublished - 2006


  • Proefschriften (vorm), chromatografische analyse, elektroforese; Peptiden, Vloeisto

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