Publication

A multi-module, microfluidic gastrointestinal tract for testing food and drugs

de Haan, P., Santbergen, M. J. C., van der Zande, M., Bouwmeester, H., Nielen, M. W. F. & Verpoorte, E., 26-Oct-2019, p. 378-379.

Research output: Contribution to conferenceAbstractAcademic

APA

de Haan, P., Santbergen, M. J. C., van der Zande, M., Bouwmeester, H., Nielen, M. W. F., & Verpoorte, E. (2019). A multi-module, microfluidic gastrointestinal tract for testing food and drugs. 378-379. Abstract from 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, Basel, Switzerland.

Author

de Haan, Pim ; Santbergen, Milou J.C. ; van der Zande, Meike ; Bouwmeester, Hans ; Nielen, Michel W.F. ; Verpoorte, Elisabeth. / A multi-module, microfluidic gastrointestinal tract for testing food and drugs. Abstract from 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, Basel, Switzerland.

Harvard

de Haan, P, Santbergen, MJC, van der Zande, M, Bouwmeester, H, Nielen, MWF & Verpoorte, E 2019, 'A multi-module, microfluidic gastrointestinal tract for testing food and drugs', 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, Basel, Switzerland, 26/10/2019 - 31/10/2019 pp. 378-379.

Standard

A multi-module, microfluidic gastrointestinal tract for testing food and drugs. / de Haan, Pim; Santbergen, Milou J.C.; van der Zande, Meike; Bouwmeester, Hans; Nielen, Michel W.F.; Verpoorte, Elisabeth.

2019. 378-379 Abstract from 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, Basel, Switzerland.

Research output: Contribution to conferenceAbstractAcademic

Vancouver

de Haan P, Santbergen MJC, van der Zande M, Bouwmeester H, Nielen MWF, Verpoorte E. A multi-module, microfluidic gastrointestinal tract for testing food and drugs. 2019. Abstract from 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, Basel, Switzerland.


BibTeX

@conference{ef3418dfdf9c406c9334ba77e1b2d430,
title = "A multi-module, microfluidic gastrointestinal tract for testing food and drugs",
abstract = "This work describes our efforts to date to realize a miniaturized gastrointestinal (GI) tract total analysis system (gut-μTAS) for nutrients or drugs upon ingestion. A multi-module flow system is being developed that seeks to combine all processes of the GI tract, including enzymatic digestion, absorption, and metabolism together with online mass spectrometry analysis. When exposing cells to digested materials (chyme), we found that the cells tolerate up to ~15% of chyme in the cellular matrix. Finally, we monitored the absorption of model drug, verapamil, in the gut-on-a-chip device by online mass spectrometry (MS) analysis.",
keywords = "Gut-on-a-chip, Digestion, Mass spectrometry, Oral bioavailability",
author = "{de Haan}, Pim and Santbergen, {Milou J.C.} and {van der Zande}, Meike and Hans Bouwmeester and Nielen, {Michel W.F.} and Elisabeth Verpoorte",
year = "2019",
month = oct,
day = "26",
language = "English",
pages = "378--379",
note = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019 ; Conference date: 26-10-2019 Through 31-10-2019",
url = "http://microtas2019.org",

}

RIS

TY - CONF

T1 - A multi-module, microfluidic gastrointestinal tract for testing food and drugs

AU - de Haan, Pim

AU - Santbergen, Milou J.C.

AU - van der Zande, Meike

AU - Bouwmeester, Hans

AU - Nielen, Michel W.F.

AU - Verpoorte, Elisabeth

N1 - Conference code: 23

PY - 2019/10/26

Y1 - 2019/10/26

N2 - This work describes our efforts to date to realize a miniaturized gastrointestinal (GI) tract total analysis system (gut-μTAS) for nutrients or drugs upon ingestion. A multi-module flow system is being developed that seeks to combine all processes of the GI tract, including enzymatic digestion, absorption, and metabolism together with online mass spectrometry analysis. When exposing cells to digested materials (chyme), we found that the cells tolerate up to ~15% of chyme in the cellular matrix. Finally, we monitored the absorption of model drug, verapamil, in the gut-on-a-chip device by online mass spectrometry (MS) analysis.

AB - This work describes our efforts to date to realize a miniaturized gastrointestinal (GI) tract total analysis system (gut-μTAS) for nutrients or drugs upon ingestion. A multi-module flow system is being developed that seeks to combine all processes of the GI tract, including enzymatic digestion, absorption, and metabolism together with online mass spectrometry analysis. When exposing cells to digested materials (chyme), we found that the cells tolerate up to ~15% of chyme in the cellular matrix. Finally, we monitored the absorption of model drug, verapamil, in the gut-on-a-chip device by online mass spectrometry (MS) analysis.

KW - Gut-on-a-chip, Digestion, Mass spectrometry, Oral bioavailability

M3 - Abstract

SP - 378

EP - 379

T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences

Y2 - 26 October 2019 through 31 October 2019

ER -

ID: 101125093