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A multi-module, microfluidic gastrointestinal tract for testing food and drugs
de Haan, P., Santbergen, M. J. C., van der Zande, M., Bouwmeester, H., Nielen, M. W. F. & Verpoorte, E., 26-Oct-2019, p. 378-379.Research output: Contribution to conference › Abstract › Academic
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A multi-module, microfluidic gastrointestinal tract for testing food and drugs. / de Haan, Pim; Santbergen, Milou J.C.; van der Zande, Meike; Bouwmeester, Hans; Nielen, Michel W.F.; Verpoorte, Elisabeth.
2019. 378-379 Abstract from 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, Basel, Switzerland.Research output: Contribution to conference › Abstract › Academic
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TY - CONF
T1 - A multi-module, microfluidic gastrointestinal tract for testing food and drugs
AU - de Haan, Pim
AU - Santbergen, Milou J.C.
AU - van der Zande, Meike
AU - Bouwmeester, Hans
AU - Nielen, Michel W.F.
AU - Verpoorte, Elisabeth
N1 - Conference code: 23
PY - 2019/10/26
Y1 - 2019/10/26
N2 - This work describes our efforts to date to realize a miniaturized gastrointestinal (GI) tract total analysis system (gut-μTAS) for nutrients or drugs upon ingestion. A multi-module flow system is being developed that seeks to combine all processes of the GI tract, including enzymatic digestion, absorption, and metabolism together with online mass spectrometry analysis. When exposing cells to digested materials (chyme), we found that the cells tolerate up to ~15% of chyme in the cellular matrix. Finally, we monitored the absorption of model drug, verapamil, in the gut-on-a-chip device by online mass spectrometry (MS) analysis.
AB - This work describes our efforts to date to realize a miniaturized gastrointestinal (GI) tract total analysis system (gut-μTAS) for nutrients or drugs upon ingestion. A multi-module flow system is being developed that seeks to combine all processes of the GI tract, including enzymatic digestion, absorption, and metabolism together with online mass spectrometry analysis. When exposing cells to digested materials (chyme), we found that the cells tolerate up to ~15% of chyme in the cellular matrix. Finally, we monitored the absorption of model drug, verapamil, in the gut-on-a-chip device by online mass spectrometry (MS) analysis.
KW - Gut-on-a-chip, Digestion, Mass spectrometry, Oral bioavailability
M3 - Abstract
SP - 378
EP - 379
T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences
Y2 - 26 October 2019 through 31 October 2019
ER -
ID: 101125093