A multi-module, microfluidic gastrointestinal tract for testing food and drugsde Haan, P., Santbergen, M. J. C., van der Zande, M., Bouwmeester, H., Nielen, M. W. F. & Verpoorte, E., 26-Oct-2019, p. 378-379.
Research output: Contribution to conference › Abstract › Academic
This work describes our efforts to date to realize a miniaturized gastrointestinal (GI) tract total analysis system (gut-μTAS) for nutrients or drugs upon ingestion. A multi-module flow system is being developed that seeks to combine all processes of the GI tract, including enzymatic digestion, absorption, and metabolism together with online mass spectrometry analysis. When exposing cells to digested materials (chyme), we found that the cells tolerate up to ~15% of chyme in the cellular matrix. Finally, we monitored the absorption of model drug, verapamil, in the gut-on-a-chip device by online mass spectrometry (MS) analysis.
|Publication status||Published - 26-Oct-2019|
|Event||23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences - Basel, Basel, Switzerland|
Duration: 26-Oct-2019 → 31-Oct-2019
Conference number: 23
|Conference||23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences|
|Abbreviated title||µTAS 2019|
|Period||26/10/2019 → 31/10/2019|
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences
26/10/2019 → 31/10/2019Basel, Switzerland
- Gut-on-a-chip, Digestion, Mass spectrometry, Oral bioavailability