Publication

A GENE IN THE CHROMOSOMAL REGION 3P21 WITH GREATLY REDUCED EXPRESSION IN LUNG-CANCER IS SIMILAR TO THE GENE FOR UBIQUITIN-ACTIVATING ENZYME

KOK, K., HOFSTRA, R., PILZ, A., van den Berg, A., TERPSTRA, P., BUYS, CHCM. & CARRITT, B., 1-Jul-1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 13, p. 6071-6075 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

KOK, K., HOFSTRA, R., PILZ, A., van den Berg, A., TERPSTRA, P., BUYS, CHCM., & CARRITT, B. (1993). A GENE IN THE CHROMOSOMAL REGION 3P21 WITH GREATLY REDUCED EXPRESSION IN LUNG-CANCER IS SIMILAR TO THE GENE FOR UBIQUITIN-ACTIVATING ENZYME. Proceedings of the National Academy of Sciences of the United States of America, 90(13), 6071-6075.

Author

KOK, K ; HOFSTRA, R ; PILZ, A ; van den Berg, Anke ; TERPSTRA, P ; BUYS, CHCM ; CARRITT, B. / A GENE IN THE CHROMOSOMAL REGION 3P21 WITH GREATLY REDUCED EXPRESSION IN LUNG-CANCER IS SIMILAR TO THE GENE FOR UBIQUITIN-ACTIVATING ENZYME. In: Proceedings of the National Academy of Sciences of the United States of America. 1993 ; Vol. 90, No. 13. pp. 6071-6075.

Harvard

KOK, K, HOFSTRA, R, PILZ, A, van den Berg, A, TERPSTRA, P, BUYS, CHCM & CARRITT, B 1993, 'A GENE IN THE CHROMOSOMAL REGION 3P21 WITH GREATLY REDUCED EXPRESSION IN LUNG-CANCER IS SIMILAR TO THE GENE FOR UBIQUITIN-ACTIVATING ENZYME', Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 13, pp. 6071-6075.

Standard

A GENE IN THE CHROMOSOMAL REGION 3P21 WITH GREATLY REDUCED EXPRESSION IN LUNG-CANCER IS SIMILAR TO THE GENE FOR UBIQUITIN-ACTIVATING ENZYME. / KOK, K; HOFSTRA, R; PILZ, A; van den Berg, Anke; TERPSTRA, P; BUYS, CHCM; CARRITT, B.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, No. 13, 01.07.1993, p. 6071-6075.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

KOK K, HOFSTRA R, PILZ A, van den Berg A, TERPSTRA P, BUYS CHCM et al. A GENE IN THE CHROMOSOMAL REGION 3P21 WITH GREATLY REDUCED EXPRESSION IN LUNG-CANCER IS SIMILAR TO THE GENE FOR UBIQUITIN-ACTIVATING ENZYME. Proceedings of the National Academy of Sciences of the United States of America. 1993 Jul 1;90(13):6071-6075.


BibTeX

@article{eda334af527445809d44e42074ca146a,
title = "A GENE IN THE CHROMOSOMAL REGION 3P21 WITH GREATLY REDUCED EXPRESSION IN LUNG-CANCER IS SIMILAR TO THE GENE FOR UBIQUITIN-ACTIVATING ENZYME",
abstract = "The chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We recently cloned a gene from this region that has greatly reduced expression in almost all lung tumor cell lines examined, in spite of being widely expressed in a variety of other tumor and nontumor cell types. We report here the sequence of this gene and show that it has significant homology to the genes encoding the ubiquitin-activating enzymes of three species, including humans. This suggests it is a second, autosomal member of this gene family in humans and may play a role in the ubiquitin conjugation pathway, which is of central importance in all eukaryotes.",
keywords = "MOUSE Y-CHROMOSOME, CYCLE MUTANT TS85, L-CELL DEFECT, MOLECULAR-CLONING, ESCHERICHIA-COLI, DNA-REPLICATION, SEQUENCE, PROTEIN",
author = "K KOK and R HOFSTRA and A PILZ and {van den Berg}, Anke and P TERPSTRA and CHCM BUYS and B CARRITT",
year = "1993",
month = jul,
day = "1",
language = "English",
volume = "90",
pages = "6071--6075",
journal = "Proceedings of the National Academy of Science of the United States of America",
issn = "0027-8424",
publisher = "NATL ACAD SCIENCES",
number = "13",

}

RIS

TY - JOUR

T1 - A GENE IN THE CHROMOSOMAL REGION 3P21 WITH GREATLY REDUCED EXPRESSION IN LUNG-CANCER IS SIMILAR TO THE GENE FOR UBIQUITIN-ACTIVATING ENZYME

AU - KOK, K

AU - HOFSTRA, R

AU - PILZ, A

AU - van den Berg, Anke

AU - TERPSTRA, P

AU - BUYS, CHCM

AU - CARRITT, B

PY - 1993/7/1

Y1 - 1993/7/1

N2 - The chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We recently cloned a gene from this region that has greatly reduced expression in almost all lung tumor cell lines examined, in spite of being widely expressed in a variety of other tumor and nontumor cell types. We report here the sequence of this gene and show that it has significant homology to the genes encoding the ubiquitin-activating enzymes of three species, including humans. This suggests it is a second, autosomal member of this gene family in humans and may play a role in the ubiquitin conjugation pathway, which is of central importance in all eukaryotes.

AB - The chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We recently cloned a gene from this region that has greatly reduced expression in almost all lung tumor cell lines examined, in spite of being widely expressed in a variety of other tumor and nontumor cell types. We report here the sequence of this gene and show that it has significant homology to the genes encoding the ubiquitin-activating enzymes of three species, including humans. This suggests it is a second, autosomal member of this gene family in humans and may play a role in the ubiquitin conjugation pathway, which is of central importance in all eukaryotes.

KW - MOUSE Y-CHROMOSOME

KW - CYCLE MUTANT TS85

KW - L-CELL DEFECT

KW - MOLECULAR-CLONING

KW - ESCHERICHIA-COLI

KW - DNA-REPLICATION

KW - SEQUENCE

KW - PROTEIN

M3 - Article

VL - 90

SP - 6071

EP - 6075

JO - Proceedings of the National Academy of Science of the United States of America

JF - Proceedings of the National Academy of Science of the United States of America

SN - 0027-8424

IS - 13

ER -

ID: 6354583