Publication

A GENE IN THE CHROMOSOMAL REGION 3P21 WITH GREATLY REDUCED EXPRESSION IN LUNG-CANCER IS SIMILAR TO THE GENE FOR UBIQUITIN-ACTIVATING ENZYME

KOK, K., HOFSTRA, R., PILZ, A., van den Berg, A., TERPSTRA, P., BUYS, CHCM. & CARRITT, B., 1-Jul-1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 13, p. 6071-6075 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

The chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We recently cloned a gene from this region that has greatly reduced expression in almost all lung tumor cell lines examined, in spite of being widely expressed in a variety of other tumor and nontumor cell types. We report here the sequence of this gene and show that it has significant homology to the genes encoding the ubiquitin-activating enzymes of three species, including humans. This suggests it is a second, autosomal member of this gene family in humans and may play a role in the ubiquitin conjugation pathway, which is of central importance in all eukaryotes.

Original languageEnglish
Pages (from-to)6071-6075
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number13
Publication statusPublished - 1-Jul-1993

    Keywords

  • MOUSE Y-CHROMOSOME, CYCLE MUTANT TS85, L-CELL DEFECT, MOLECULAR-CLONING, ESCHERICHIA-COLI, DNA-REPLICATION, SEQUENCE, PROTEIN

ID: 6354583