Publication

A GENE FROM HUMAN-CHROMOSOME REGION-3P21 WITH REDUCED EXPRESSION IN SMALL-CELL LUNG-CANCER

CARRITT, B., KOK, K., van den Berg, A., OSINGA, J., PILZ, A., HOFSTRA, RMW., DAVIS, MB., VANDERVEEN, AY., RABBITTS, PH., GULATI, K. & BUYS, CHCM., 15-Mar-1992, In : Cancer Research. 52, 6, p. 1536-1541 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

A combination of cytogenetic and molecular studies has implicated the p21 region of human chromosome 3 as the probable site of a gene the loss of which contributes to the development of small cell lung cancer. We report here the isolation of a gene from this region which is expressed in normal lung tissue and in cell lines derived from a number of different types of tumor, but the expression of which in small cell lung cancer cell lines is undetectable by RNA blot analysis. Although the more sensitive polymerase chain reaction did detect transcripts, a novel quantitative polymerase chain reaction assay showed that their concentration in small cell lung cancer cell lines is less than 3% of that in normal lung.

Original languageEnglish
Pages (from-to)1536-1541
Number of pages6
JournalCancer Research
Volume52
Issue number6
Publication statusPublished - 15-Mar-1992

    Keywords

  • TUMOR SUPPRESSOR GENES, HOMOZYGOUS DELETION, SHORT ARM, CARCINOMA, LINES, LOCUS, IDENTIFICATION, ESTABLISHMENT, AMPLIFICATION, LOCALIZATION

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