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A facile approach to hydrophilic oxidized fullerenes and their derivatives as cytotoxic agents and supports for nanobiocatalytic systems

Zygouri, P., Spyrou, K., Mitsari, E., Barrio, M., Macovez, R., Patila, M., Stamatis, H., Verginadis, I. I., Velalopoulou, A. P., Evangelou, A. M., Sideratou, Z., Gournis, D. & Rudolf, P., 19-May-2020, In : Scientific Reports. 10, 1, 13 p., 8244.

Research output: Contribution to journalArticleAcademicpeer-review

  • Panagiota Zygouri
  • Konstantinos Spyrou
  • Efstratia Mitsari
  • Maria Barrio
  • Roberto Macovez
  • Michaela Patila
  • Haralambos Stamatis
  • Ioannis I. Verginadis
  • Anastasia P. Velalopoulou
  • Angelos M. Evangelou
  • Zili Sideratou
  • Dimitrios Gournis
  • Petra Rudolf

A facile, environment-friendly, versatile and reproducible approach to the successful oxidation of fullerenes (oxC(60)) and the formation of highly hydrophilic fullerene derivatives is introduced. This synthesis relies on the widely known Staudenmaier's method for the oxidation of graphite, to produce both epoxy and hydroxy groups on the surface of fullerenes (C-60) and thereby improve the solubility of the fullerene in polar solvents (e.g. water). The presence of epoxy groups allows for further functionalization via nucleophilic substitution reactions to generate new fullerene derivatives, which can potentially lead to a wealth of applications in the areas of medicine, biology, and composite materials. In order to justify the potential of oxidized C-60 derivatives for bio-applications, we investigated their cytotoxicity in vitro as well as their utilization as support in biocatalysis applications, taking the immobilization of laccase for the decolorization of synthetic industrial dyes as a trial case.

Original languageEnglish
Article number8244
Number of pages13
JournalScientific Reports
Volume10
Issue number1
Publication statusPublished - 19-May-2020

    Keywords

  • GRAPHENE OXIDE, AZOMETHINE YLIDES, RAMAN-SPECTRA, C-60, WATER, CHEMISTRY, C60, BUCKMINSTERFULLERENE, OXIDATION, FUNCTIONALIZATION

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