A DISCORDANCE BETWEEN THE HUMAN MUSCLE NCAM SEQUENCE AND THOSE SEEN IN OTHER NCAM CDNA CLONESROSSELL, RJ., MALIK, A., HELFRICH, W., KEMSHEAD, JT. & PATEL, K., 28-Feb-1992, In : Biochimica et biophysica acta. 1130, 1, p. 95-96 2 p.
Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review
A cDNA clone, designated NC7, has been isolated from human foetal kidney that partially codes for the 140 kDa isoform of human NCAM. This clone contains a 6 bp insert that is not present in the human muscle cDNA clone lambda-4.4. This same sequence has also been found in both a cDNA clone obtained from a human Small Cell Lung Carcinoma (SCLC) line and in human genomic DNA. Furthermore, an equivalent sequence to the 6 bp region identified in the above samples is present in mouse, rat and chicken NCAM. The 6 bp insertion does not lie at a predicted intron/exon boundary as extrapolated by homology studies with the chicken and, therefore, the mechanism by which the sequence is deleted from the human muscle clone lambda-4.4 remains unclear.
- NEURAL CELL ADHESION MOLECULE (NCAM), KIDNEY, DNA SEQUENCE, (HUMAN MUSCLE), CELL-ADHESION MOLECULE, N-CAM, EXON USAGE, DOMAINS, BRAIN, GENE