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A conserved function for Inp2 in peroxisome inheritance

Saraya, R., Cepinska, M. N., Kiel, J. A. K. W., Veenhuis, M., van der Klei, I. J. & Cepińska, M. N., May-2010, In : Biochimica et Biophysica Acta-Molecular Cell Research. 1803, 5, p. 617 - 622 6 p.

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DOI

In budding yeast Saccharomyces cerevisiae, the peroxisomal protein Inp2 is required for inheritance of peroxisomes to the bud, by connecting the organelles to the motor protein Myo2 and the actin cytoskeleton. Recent data suggested that the function of Inp2 may not be conserved in other yeast species. Using in silico analyses we have identified a weakly conserved Inp2-related protein in 18 species of budding yeast and analyzed the role of the identified protein in the methylotrophic yeast Hansenula polymorpha in peroxisome inheritance. Our data show that H. polymorpha Inp2 locates to peroxisomes, interacts with Myo2, and is essential for peroxisome inheritance. (C) 2010 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)617 - 622
Number of pages6
JournalBiochimica et Biophysica Acta-Molecular Cell Research
Volume1803
Issue number5
Publication statusPublished - May-2010

    Keywords

  • Budding yeast, Cytoskeleton, Organelle inheritance, Peroxisome, Protein-protein interaction, HANSENULA-POLYMORPHA, SACCHAROMYCES-CEREVISIAE, YARROWIA-LIPOLYTICA, MEMBRANE-PROTEINS, METABOLISM, GENES, PROLIFERATION, SIMILARITY, EFFICIENT, ALIGNMENT

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