A clinical validation study for application of DBS in therapeutic drug monitoring of antidepressantsBerm, E. J. J., Odigie, B., Bijlsma, M. J., Wilffert, B., Touw, D. J. & Maring, J. G., 19-Feb-2016, In : Bioanalysis. 8, 5, p. 413-424 12 p.
Research output: Contribution to journal › Article › Academic › peer-review
- Pharmacotherapy and Pharmaceutical Care
- Pharmacoepidemiology and Pharmacoeconomics
- Methods in Medicines evaluation & Outcomes research (M2O)
- Reproductive Origins of Adult Health and Disease (ROAHD)
- PharmacoTherapy, Epidemiology and Economics
- Pharmacokinetics, Toxicology and Targeting
- Biopharmaceuticals, Discovery, Design and Delivery (BDDD)
- Groningen Research Institute for Asthma and COPD (GRIAC)
- Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)
BACKGROUND: A bridging study of plasma and DBS concentrations for therapeutic drug monitoring of antidepressants was performed. Results & methodology: Potassium-based hematocrit analysis was included. In addition, we defined acceptance criteria based on the differences between individual data points of plasma and DBS concentrations. These criteria were applied to test acceptability of error found in predicted nortriptyline plasma concentrations. Potassium-based hematocrit predicted a negative bias for DBS concentrations of amitriptyline, but not for the other compounds. To predict plasma concentrations of antidepressants based on DBS concentrations, a factor of 0.8, 0.65, 0.84 and 0.78 was found for nortriptyline, desmethylclomipramine, venlafaxine and desmethylvenlafaxine, respectively.
DISCUSSION & CONCLUSION: Application of the factor and newly formulated acceptance criteria demonstrated prediction of nortriptyline plasma concentrations based on DBS concentrations.
|Number of pages||12|
|Publication status||Published - 19-Feb-2016|
- antidepressants, clinical validation, DBS, plasma, therapeutic drug monitoring, DRIED BLOOD SPOTS, LC-MS/MS, QUANTITATIVE-ANALYSIS, POTASSIUM MEASUREMENT, ASSAY BIAS, HEMATOCRIT, CLOMIPRAMINE, METABOLITES, CAPILLARY, PHARMACOKINETICS