Publication

A catalog of genetic loci associated with kidney function from analyses of a million individuals

Lifelines Cohort Study, Wuttke, M., Li, Y., Li, M., Sieber, K. B., Feitosa, M. F., Gorski, M., Tin, A., Wang, L., Chu, A. Y., Hoppmann, A., Kirsten, H., Giri, A., Chai, J-F., Sveinbjornsson, G., Tayo, B. O., Nutile, T., Fuchsberger, C., Marten, J., Cocca, M., Ghasemi, S., Xu, Y., Horn, K., Noce, D., Van der Most, P. J., Sedaghat, S., Yu, Z., Akiyama, M., Afaq, S., Ahluwalia, T. S., Almgren, P., Amin, N., Arnlov, J., Bakker, S. J. L., Bansal, N., De Borst, M. H., De Vries, A. P. J., Demirkan, A., Gansevoort, R. T., Hartman, C. A., Huang, W., Nolte, I. M., Oldehinkel, A. J., Penninx, B. W. J. H., Prins, B. P., Smith, A. V., Van der Harst, P., Verweij, N., Wang, Y. X., Xu, L., Snieder, H. & Thio, C. H. L., Jun-2019, In : Nature Genetics. 51, 6, p. 957-+ 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Lifelines Cohort Study, Wuttke, M., Li, Y., Li, M., Sieber, K. B., Feitosa, M. F., Gorski, M., Tin, A., Wang, L., Chu, A. Y., Hoppmann, A., Kirsten, H., Giri, A., Chai, J-F., Sveinbjornsson, G., Tayo, B. O., Nutile, T., Fuchsberger, C., Marten, J., ... Thio, C. H. L. (2019). A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nature Genetics, 51(6), 957-+. https://doi.org/10.1038/s41588-019-0407-x

Author

Lifelines Cohort Study ; Wuttke, Matthias ; Li, Yong ; Li, Man ; Sieber, Karsten B. ; Feitosa, Mary F. ; Gorski, Mathias ; Tin, Adrienne ; Wang, Lihua ; Chu, Audrey Y. ; Hoppmann, Anselm ; Kirsten, Holger ; Giri, Ayush ; Chai, Jin-Fang ; Sveinbjornsson, Gardar ; Tayo, Bamidele O. ; Nutile, Teresa ; Fuchsberger, Christian ; Marten, Jonathan ; Cocca, Massimiliano ; Ghasemi, Sahar ; Xu, Yizhe ; Horn, Katrin ; Noce, Damia ; Van der Most, Peter J. ; Sedaghat, Sanaz ; Yu, Zhi ; Akiyama, Masato ; Afaq, Saima ; Ahluwalia, Tarunveer S. ; Almgren, Peter ; Amin, Najaf ; Arnlov, Johan ; Bakker, Stephan J. L. ; Bansal, Nisha ; De Borst, Martin H. ; De Vries, Aiko P. J. ; Demirkan, Ayse ; Gansevoort, Ron T. ; Hartman, Catharina A. ; Huang, Wei ; Nolte, Ilja M. ; Oldehinkel, Albertine J. ; Penninx, Brenda W. J. H. ; Prins, Bram P. ; Smith, Albert V. ; Van der Harst, Pim ; Verweij, Niek ; Wang, Ya Xing ; Xu, Liang ; Snieder, Harold ; Thio, C. H. L. / A catalog of genetic loci associated with kidney function from analyses of a million individuals. In: Nature Genetics. 2019 ; Vol. 51, No. 6. pp. 957-+.

Harvard

Lifelines Cohort Study, Wuttke, M, Li, Y, Li, M, Sieber, KB, Feitosa, MF, Gorski, M, Tin, A, Wang, L, Chu, AY, Hoppmann, A, Kirsten, H, Giri, A, Chai, J-F, Sveinbjornsson, G, Tayo, BO, Nutile, T, Fuchsberger, C, Marten, J, Cocca, M, Ghasemi, S, Xu, Y, Horn, K, Noce, D, Van der Most, PJ, Sedaghat, S, Yu, Z, Akiyama, M, Afaq, S, Ahluwalia, TS, Almgren, P, Amin, N, Arnlov, J, Bakker, SJL, Bansal, N, De Borst, MH, De Vries, APJ, Demirkan, A, Gansevoort, RT, Hartman, CA, Huang, W, Nolte, IM, Oldehinkel, AJ, Penninx, BWJH, Prins, BP, Smith, AV, Van der Harst, P, Verweij, N, Wang, YX, Xu, L, Snieder, H & Thio, CHL 2019, 'A catalog of genetic loci associated with kidney function from analyses of a million individuals', Nature Genetics, vol. 51, no. 6, pp. 957-+. https://doi.org/10.1038/s41588-019-0407-x

Standard

A catalog of genetic loci associated with kidney function from analyses of a million individuals. / Lifelines Cohort Study; Wuttke, Matthias; Li, Yong; Li, Man; Sieber, Karsten B.; Feitosa, Mary F.; Gorski, Mathias; Tin, Adrienne; Wang, Lihua; Chu, Audrey Y.; Hoppmann, Anselm; Kirsten, Holger; Giri, Ayush; Chai, Jin-Fang; Sveinbjornsson, Gardar; Tayo, Bamidele O.; Nutile, Teresa; Fuchsberger, Christian; Marten, Jonathan; Cocca, Massimiliano; Ghasemi, Sahar; Xu, Yizhe; Horn, Katrin; Noce, Damia; Van der Most, Peter J.; Sedaghat, Sanaz; Yu, Zhi; Akiyama, Masato; Afaq, Saima; Ahluwalia, Tarunveer S.; Almgren, Peter; Amin, Najaf; Arnlov, Johan; Bakker, Stephan J. L.; Bansal, Nisha; De Borst, Martin H.; De Vries, Aiko P. J.; Demirkan, Ayse; Gansevoort, Ron T.; Hartman, Catharina A.; Huang, Wei; Nolte, Ilja M.; Oldehinkel, Albertine J.; Penninx, Brenda W. J. H.; Prins, Bram P.; Smith, Albert V.; Van der Harst, Pim; Verweij, Niek; Wang, Ya Xing; Xu, Liang; Snieder, Harold; Thio, C. H. L.

In: Nature Genetics, Vol. 51, No. 6, 06.2019, p. 957-+.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Lifelines Cohort Study, Wuttke M, Li Y, Li M, Sieber KB, Feitosa MF et al. A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nature Genetics. 2019 Jun;51(6):957-+. https://doi.org/10.1038/s41588-019-0407-x


BibTeX

@article{227ca0bdb98c4d7497c999b72b14d71e,
title = "A catalog of genetic loci associated with kidney function from analyses of a million individuals",
abstract = "Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.",
keywords = "GENOME-WIDE ASSOCIATION, COMMON VARIANTS, RENAL-FUNCTION, TRANS-EQTLS, DISEASE, METAANALYSIS, TRANSPORTER, CLASSIFICATION, HERITABILITY, INTEGRATION",
author = "{Lifelines Cohort Study} and Matthias Wuttke and Yong Li and Man Li and Sieber, {Karsten B.} and Feitosa, {Mary F.} and Mathias Gorski and Adrienne Tin and Lihua Wang and Chu, {Audrey Y.} and Anselm Hoppmann and Holger Kirsten and Ayush Giri and Jin-Fang Chai and Gardar Sveinbjornsson and Tayo, {Bamidele O.} and Teresa Nutile and Christian Fuchsberger and Jonathan Marten and Massimiliano Cocca and Sahar Ghasemi and Yizhe Xu and Katrin Horn and Damia Noce and {Van der Most}, {Peter J.} and Sanaz Sedaghat and Zhi Yu and Masato Akiyama and Saima Afaq and Ahluwalia, {Tarunveer S.} and Peter Almgren and Najaf Amin and Johan Arnlov and Bakker, {Stephan J. L.} and Nisha Bansal and {De Borst}, {Martin H.} and {De Vries}, {Aiko P. J.} and Ayse Demirkan and Gansevoort, {Ron T.} and Hartman, {Catharina A.} and Wei Huang and Nolte, {Ilja M.} and Oldehinkel, {Albertine J.} and Penninx, {Brenda W. J. H.} and Prins, {Bram P.} and Smith, {Albert V.} and {Van der Harst}, Pim and Niek Verweij and Wang, {Ya Xing} and Liang Xu and Harold Snieder and Thio, {C. H. L.}",
year = "2019",
month = jun,
doi = "10.1038/s41588-019-0407-x",
language = "English",
volume = "51",
pages = "957--+",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "6",

}

RIS

TY - JOUR

T1 - A catalog of genetic loci associated with kidney function from analyses of a million individuals

AU - Lifelines Cohort Study

AU - Wuttke, Matthias

AU - Li, Yong

AU - Li, Man

AU - Sieber, Karsten B.

AU - Feitosa, Mary F.

AU - Gorski, Mathias

AU - Tin, Adrienne

AU - Wang, Lihua

AU - Chu, Audrey Y.

AU - Hoppmann, Anselm

AU - Kirsten, Holger

AU - Giri, Ayush

AU - Chai, Jin-Fang

AU - Sveinbjornsson, Gardar

AU - Tayo, Bamidele O.

AU - Nutile, Teresa

AU - Fuchsberger, Christian

AU - Marten, Jonathan

AU - Cocca, Massimiliano

AU - Ghasemi, Sahar

AU - Xu, Yizhe

AU - Horn, Katrin

AU - Noce, Damia

AU - Van der Most, Peter J.

AU - Sedaghat, Sanaz

AU - Yu, Zhi

AU - Akiyama, Masato

AU - Afaq, Saima

AU - Ahluwalia, Tarunveer S.

AU - Almgren, Peter

AU - Amin, Najaf

AU - Arnlov, Johan

AU - Bakker, Stephan J. L.

AU - Bansal, Nisha

AU - De Borst, Martin H.

AU - De Vries, Aiko P. J.

AU - Demirkan, Ayse

AU - Gansevoort, Ron T.

AU - Hartman, Catharina A.

AU - Huang, Wei

AU - Nolte, Ilja M.

AU - Oldehinkel, Albertine J.

AU - Penninx, Brenda W. J. H.

AU - Prins, Bram P.

AU - Smith, Albert V.

AU - Van der Harst, Pim

AU - Verweij, Niek

AU - Wang, Ya Xing

AU - Xu, Liang

AU - Snieder, Harold

AU - Thio, C. H. L.

PY - 2019/6

Y1 - 2019/6

N2 - Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.

AB - Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.

KW - GENOME-WIDE ASSOCIATION

KW - COMMON VARIANTS

KW - RENAL-FUNCTION

KW - TRANS-EQTLS

KW - DISEASE

KW - METAANALYSIS

KW - TRANSPORTER

KW - CLASSIFICATION

KW - HERITABILITY

KW - INTEGRATION

U2 - 10.1038/s41588-019-0407-x

DO - 10.1038/s41588-019-0407-x

M3 - Article

C2 - 31152163

VL - 51

SP - 957-+

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 6

ER -

ID: 84381302