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1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction

Wang, Q., Mgimpatsang, K. C., Konstantinidou, M., Shishkina, S. V. & Dömling, A., 20-Sep-2019, In : Organic letters. 21, 18, p. 7320-7323 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Easy to perform, functional group tolerant, and short syntheses of the privileged scaffold oxadiazole are highly desired. Here, a metal-free protocol for MCR-based synthesis of 2,5-disubstituted 1,3,4-oxadiazoles via a Ugi-tetrazole/Huisgen sequence was developed. Optimization and scope and limitations of this short and general sequence are described. The reaction was also successfully performed on a gram scale.
Original languageEnglish
Pages (from-to)7320-7323
Number of pages4
JournalOrganic letters
Volume21
Issue number18
Publication statusPublished - 20-Sep-2019

    Keywords

  • article, synthesis, unclassified drug

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