The Polymyalgia Rheumatica Bursitis Study


Kornelis van der Geest (Recipient), Liesbeth Brouwer (Recipient) & Annemieke M. H. Boots (Recipient)

1c. Summary of research proposal (300 words)
PMR is a common, aging-associated, rheumatic disease with a lifetime risk of 2.4% in women and 1.7% in men (1). The prevalence of this aging-associated disease is expected to rise markedly in the coming years, as Western populations are aging rapidly. PMR is characterized by disabling pain and stiffness of shoulders and hips due to inflammation of bursal and joint synovium. Half of the PMR patients can be successfully withdrawn from standard glucocorticoid therapy after 1-2 years, whereas the other half frequently relapses and requires long-term maintenance treatment (2-5). It remains to be elucidated which biological factors determine this different outcome in PMR patients. Currently, little is known about the synovial immune pathology in PMR patients. Consequently, a rationale for targeted therapies is lacking for PMR. In this project, I will investigate synovial tissue of PMR patients obtained by ultrasound-guided biopsy of shoulder bursal synovium. I will perform a comprehensive histological analysis of PMR synovium. I expect that this project will markedly increase our understanding of the immune pathology of PMR. All PMR patients will be managed according to a protocolized treatment and follow-up protocol. Consequently, this project will allow to identify immune pathways that are upregulated in relapsing PMR patients. Taken together, this project will establish a rationale for already existing targeted therapies, and help to define new targets for treatment in PMR patients. Hence, this project represents the first step towards precision medicine in PMR.
Awarded date9-Jan-2018
Degree of recognitionInternational
Granting OrganisationsMandema Stipendium

ID: 52309456