W.J. Kolff Institute for Biomedical Engineering and Materials Science (KOLFF)

University of Groningen > Faculteit Medische Wetenschappen/UMCG > W.J. Kolff Institute for Biomedical Engineering and Materials Science (KOLFF)

Contact information

Antonius Deusinglaan 1, FB41
9713 AV
  • Phone: +31 50 3633140

Organisational unit profile

The W.J. Kolff Institute for Biomedical Engineering and Materials Science was established on October 8th, 1997. The institute is named after Willem Johan Kolff, who as a resident in Groningen, developed the first functioning artificial kidney in the 1940th and saved lives of millions of patients ever since.

The use of biomaterials implants has become an integral part of modern health care in the Western world. Modern health care could not even exist without biomaterials and the restoration of function after oncological surgery, trauma or simply wear due to advanced age would be impossible. With the average life expectancy approaching 80 years, the use of biomaterials will increase due to the demands of the ageing population for a high quality of life.

The mission statement of the W.J. Kolff Institute is to establish a center of expertise for the entire stage of biomedical materials science and its application involving basic materials science, medical product development and clinical evaluation that will contribute to the long-lasting well-being of patients in need of biomaterials implants and extra-corporal support systems.

Research Focus and Strategy

  • Bioadhesion, biocompatibility and infection: Focusses on the prevention of biofilm formation on all biomaterials implants and devices, its aims are formulated with respect to the infection prevention of temporarily and permanent implants and devices.
  • Nanobiotechnology and advanced therapeutic materials: Employs tools from nanobiotechnology to fabricate powerful drug carrier systems and nanoscale surface coatings.
  • Restoring organ function by means of regenerative medicine: Focuses on various aspects of tissue (re) generation, repair and remodelling, including inflammation.
  • Maintaining oral health and oral function: Provides new tools for prevention of oral health disorders to occur and to produce new strategies to restore and maintain oral health and function during life with minimal costs and efforts.


Scientific Director


Prof. dr. H.C. van der Mei
E-mail: h.c.van.der.mei@umcg.nl
Phone: +31 50 3633140
Fax: +31 50 3633159


  1. Sortase mutants with improved protein thermostability and enzymatic activity obtained by consensus design

    Wójcik, M., Vázquez Torres, S., Quax, W. J. & Boersma, Y. L., 29-Jul-2020, In : Protein Engineering, Design & Selection. 32, 12, p. 555-564 10 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Deep learning for automated exclusion of cardiac CT examinations negative for coronary artery calcium

    van den Oever, L. B., Cornelissen, L., Vonder, M., Xia, C., van Bolhuis, J. N., Vliegenthart, R., Veldhuis, R. N. J., de Bock, G. H., Oudkerk, M. & van Ooijen, P. M. A., Aug-2020, In : European Journal of Radiology. 129, 7 p., 109114.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Health-related quality of life in facial palsy: translation and validation of the Dutch version Facial Disability Index

    van Veen, M. M., Bruins, T. E., Artan, M., Mooibroek-Leeuwerke, T., Beurskens, C. H. G., Werker, P. M. N. & Dijkstra, P. U., 31-Jul-2020, In : HEALTH AND QUALITY OF LIFE OUTCOMES. 18, 1, 8 p., 256.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Automated synthesis, preclinical toxicity, and radiation dosimetry of [ 18 F]MC225 for clinical use: a tracer for measuring P-glycoprotein function at the blood-brain barrier

    Toyohara, J., Sakata, M., Tago, T., Colabufo, N. A. & Luurtsema, G., 22-Jul-2020, In : EJNMMI Research. 10, 11 p., 84.

    Research output: Contribution to journalArticleAcademicpeer-review

View all (7,191) »

  1. Dataset: Ovalbumin-containing core-shell implants suitable to obtain a delayed IgG1 antibody response in support of a biphasic pulsatile release profile in mice

    Amssoms, K. (Creator), Born, P. (Creator), Beugeling, M. (Creator), De Clerck, B. (Creator), Van Gulck, E. (Creator), Hinrichs, W. (Creator), Frijlink, E. (Creator), Grasmeijer, N. (Creator), Kraus, G. (Creator), Sutmuller, R. (Creator), Simmen, K. (Creator), Baert, L. (Creator), University of Groningen, 17-Aug-2018


  2. Data for: ColiCoords: A Python package for the analysis of bacterial fluorescence microscopy data

    Smit, J. (Creator), Li, Y. (Creator), Warszawik, E. (Creator), Hermann, A. (Creator), Cordes, T. (Creator), University of Groningen, 12-Apr-2019


  3. Data from: Sialendoscopy enhances salivary gland function in Sjögren’s syndrome: a 6 month follow-up, randomized and controlled, single blind study

    Karagozoglu, K. H. (Creator), Vissink, A. (Creator), Forouzanfar, T. (Creator), Brand, H. S. (Creator), Maarse, F. (Creator), Jager, D. (Creator), University of Groningen, 28-Feb-2018


View all (5) »

  1. 3e prijs NT-Verhalenwedstrijd 2019

    Anita Visser (Recipient), 13-Dec-2019


  2. Consultant at Sangamo Therapeutics Inc

    Marianne Rots (Recipient), 2019

    Prize: National/international honourProfessional

  3. Editor-in-Chief

    Marianne Rots (Recipient), 2019

    Prize: National/international honourAcademic

View all (27) »

  1. The Art of Building Small

    Ben L. Feringa (Invited speaker)

    Activity: Talk or presentationAcademic

  2. Science Meets Art: How to Shape the Future of Humanity

    Ben L. Feringa (Keynote speaker)

    Activity: Talk or presentationAcademic

  3. The Joy of Discovery

    Ben L. Feringa (Keynote speaker)

    Activity: Talk or presentationAcademic

View all (864) »

Press / Media
  1. Moleculaire processen zichtbaar maken met PET

    Erik Vries, de


    1 Media contribution

    Press/Media: ResearchProfessional

  2. Zorgen over opstarten orthopedische zorg de achterstand halen we niet snel in

    Sjoerd Bulstra


    1 Media contribution

    Press/Media: Public Engagement ActivitiesPopular

  3. Artsen bezorgd over gebruik urgentielijst als triagemiddel.

    Sjoerd Bulstra


    1 Media contribution

    Press/Media: Expert CommentAcademic

View all (42) »

ID: 34668