W.J. Kolff Institute for Biomedical Engineering and Materials Science

University of Groningen > Faculty of Medical Sciences > W.J. Kolff Institute for Biomedical Engineering and Materials Science (KOLFF)

Contact information

Antonius Deusinglaan 1, FB41
9713 AV
  • Phone: +31 50 3633140

Organisational unit profile

The W.J. Kolff Institute for Biomedical Engineering and Materials Science was established on October 8th, 1997. The institute is named after Willem Johan Kolff, who as a resident in Groningen, developed the first functioning artificial kidney in the 1940th and saved lives of millions of patients ever since.

The use of biomaterials implants has become an integral part of modern health care in the Western world. Modern health care could not even exist without biomaterials and the restoration of function after oncological surgery, trauma or simply wear due to advanced age would be impossible. With the average life expectancy approaching 80 years, the use of biomaterials will increase due to the demands of the ageing population for a high quality of life.

The mission statement of the W.J. Kolff Institute is to establish a center of expertise for the entire stage of biomedical materials science and its application involving basic materials science, medical product development and clinical evaluation that will contribute to the long-lasting well-being of patients in need of biomaterials implants and extra-corporal support systems.

Research Focus and Strategy

  • Bioadhesion, biocompatibility and infection: Focusses on the prevention of biofilm formation on all biomaterials implants and devices, its aims are formulated with respect to the infection prevention of temporarily and permanent implants and devices.
  • Nanobiotechnology and advanced therapeutic materials: Employs tools from nanobiotechnology to fabricate powerful drug carrier systems and nanoscale surface coatings.
  • Restoring organ function by means of regenerative medicine: Focuses on various aspects of tissue (re) generation, repair and remodelling, including inflammation.
  • Maintaining oral health and oral function: Provides new tools for prevention of oral health disorders to occur and to produce new strategies to restore and maintain oral health and function during life with minimal costs and efforts.


Scientific Director


Prof. dr. H.C. van der Mei
E-mail: h.c.van.der.mei@umcg.nl
Phone: +31 50 3633140
Fax: +31 50 3633159


  1. Readability of Dutch online patient-directed health information on breast reconstruction

    Bletsis, P. P., Egeler, S., van der Lei, B., Lee, B. T. & Lin, S. J., Aug-2019, In : European Journal of Plastic Surgery. 42, 4, p. 343-350 8 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Long-term results of the iBP elbow prosthesis: beware of destructive metallosis!

    Meijering, D., Boerboom, A. L., Breukelman, F., Eygendaal, D., Bulstra, S. K. & Stevens, M., 6-Sep-2019, In : Bmc Musculoskeletal Disorders. 20, 1, p. 415

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Eosinopenia and post-hospital outcomes in critically ill non-cardiac vascular surgery patients

    von Meijenfeldt, G. C., Chary, S., van der Laan, M. J., Zeebregts, C. J. A. M. & Christopher, K. B., Aug-2019, In : NMCD : Nutrition, Metabolism and Cardiovascular Diseases. 29, 8, p. 847-855 9 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Necrostatin-1 supplementation enhances young porcine islet maturation and in vitro function

    Lau, H., Corrales, N., Alexander, M., Mohammadi, M. R., Li, S., Smink, A. M., de Vos, P. & Lakey, J. R. T., 18-Sep-2019, In : Xenotransplantation. p. e12555

    Research output: Contribution to journalArticleAcademicpeer-review

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  1. Dataset: Ovalbumin-containing core-shell implants suitable to obtain a delayed IgG1 antibody response in support of a biphasic pulsatile release profile in mice

    Amssoms, K. (Creator), Born, P. (Creator), Beugeling, M. (Creator), De Clerck, B. (Creator), Van Gulck, E. (Creator), Hinrichs, W. (Creator), Frijlink, E. (Creator), Grasmeijer, N. (Creator), Kraus, G. (Creator), Sutmuller, R. (Creator), Simmen, K. (Creator), Baert, L. (Creator), University of Groningen, 17-Aug-2018


  2. Data from: Sialendoscopy enhances salivary gland function in Sjögren’s syndrome: a 6 month follow-up, randomized and controlled, single blind study

    Karagozoglu, K. H. (Creator), Vissink, A. (Creator), Forouzanfar, T. (Creator), Brand, H. S. (Creator), Maarse, F. (Creator), Jager, D. (Creator), University of Groningen, 28-Feb-2018


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  1. Distinguished Service Award

    Edwin Winkel (Recipient), 2016

    Prize: National/international honourAcademic

  2. VMTI publicatie prijs

    Arie Hoeksema (Recipient), Sophie Spoorenberg (Recipient), Lilian Peters (Recipient), Hendrikus Meijer (Recipient), Gerry Raghoebar (Recipient), Arjan Vissink (Recipient), Klaske Wynia (Recipient) & Anita Visser (Recipient), 6-Oct-2017


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  1. Nederlandse Vereniging voor Matrix Biologie (Dutch Society for Matirx Biology) (External organisation)

    Janette Burgess (Member)

    Activity: MembershipMembership of boardProfessional

  2. Netherlands Respiratory Society (NRS) (External organisation)

    Janette Burgess (Member)

    Activity: MembershipMembership of boardProfessional

  3. Epigenetic Editing: reprogramming nuclear and mitochondrial gene expression

    Marianne Rots (Speaker)

    Activity: Talk or presentationAcademic

View all (260) »

Press / Media
  1. Muur rond de hersenen

    Inge Zuhorn


    1 media contribution

    Press/Media: Expert CommentPopular

  2. Interview on Dutch radio station Radio Noord

    Romana Schirhagl


    1 media contribution

    Press/Media: Public Engagement ActivitiesPopular

  3. Voor het eerst extra gen gericht in lichaam gebouwd

    Marianne Rots


    1 item of media coverage

    Press/Media: Expert CommentPopular

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