W.J. Kolff Institute for Biomedical Engineering and Materials Science

University of Groningen > Faculty of Medical Sciences > W.J. Kolff Institute for Biomedical Engineering and Materials Science (KOLFF)

Contact information

Antonius Deusinglaan 1, FB41
9713 AV
Groningen
Netherlands
  • Phone: +31 50 3633140

Organisational unit profile

The W.J. Kolff Institute for Biomedical Engineering and Materials Science was established on October 8th, 1997. The institute is named after Willem Johan Kolff, who as a resident in Groningen, developed the first functioning artificial kidney in the 1940th and saved lives of millions of patients ever since.

The use of biomaterials implants has become an integral part of modern health care in the Western world. Modern health care could not even exist without biomaterials and the restoration of function after oncological surgery, trauma or simply wear due to advanced age would be impossible. With the average life expectancy approaching 80 years, the use of biomaterials will increase due to the demands of the ageing population for a high quality of life.

The mission statement of the W.J. Kolff Institute is to establish a center of expertise for the entire stage of biomedical materials science and its application involving basic materials science, medical product development and clinical evaluation that will contribute to the long-lasting well-being of patients in need of biomaterials implants and extra-corporal support systems.

Research Focus and Strategy

  • Bioadhesion, biocompatibility and infection: Focusses on the prevention of biofilm formation on all biomaterials implants and devices, its aims are formulated with respect to the infection prevention of temporarily and permanent implants and devices.
  • Nanobiotechnology and advanced therapeutic materials: Employs tools from nanobiotechnology to fabricate powerful drug carrier systems and nanoscale surface coatings.
  • Restoring organ function by means of regenerative medicine: Focuses on various aspects of tissue (re) generation, repair and remodelling, including inflammation.
  • Maintaining oral health and oral function: Provides new tools for prevention of oral health disorders to occur and to produce new strategies to restore and maintain oral health and function during life with minimal costs and efforts.

 

Scientific Director

 

Prof. dr. H.C. van der Mei
E-mail: h.c.van.der.mei@umcg.nl
Phone: +31 50 3633140
Fax: +31 50 3633159

 

Publications
  1. The timeline of epigenetic drug discovery: from reality to dreams

    Ganesan, A., Arimondo, P. B., Rots, M. G., Jeronimo, C. & Berdasco, M., 2-Dec-2019, In : Clinical Epigenetics. 11, 1, p. 174

    Research output: Contribution to journalReview articleAcademicpeer-review

  2. Combined dietary supplementation of long chain inulin and Lactobacillus acidophilus W37 supports oral vaccination efficacy against Salmonella Typhimurium in piglets

    Lepine, A. F. P., Konstanti, P., Borewicz, K., Resink, J-W., de Wit, N. J., de Vos, P., Smidt, H. & Mes, J. J., 29-Nov-2019, In : Scientific Reports. 9, 13 p., 18017.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci

    Jones, G. T., Tromp, G., Kuivaniemi, H., Gretarsdottir, S., Baas, A. F., Giusti, B., Strauss, E., Van't Hof, F. N. G., Webb, T. R., Erdman, R., Ritchie, M. D., Elmore, J. R., Verma, A., Pendergrass, S., Kullo, I. J., Ye, Z., Peissig, P. L., Gottesman, O., Verma, S. S., Malinowski, J., Rasmussen-Torvik, L. J., Borthwick, K. M., Smelser, D. T., Crosslin, D. R., de Andrade, M., Ryer, E. J., McCarty, C. A., Böttinger, E. P., Pacheco, J. A., Crawford, D. C., Carrell, D. S., Gerhard, G. S., Franklin, D. P., Carey, D. J., Phillips, V. L., Williams, M. J. A., Wei, W., Blair, R., Hill, A. A., Vasudevan, T. M., Lewis, D. R., Thomson, I. A., Krysa, J., Hill, G. B., Roake, J., Merriman, T. R., Wijmenga, C., Zeebregts, C. J., de Vries, J-P. & Sayers, R. D., 20-Jan-2017, In : Circulation research. 120, 2, p. 341-353 13 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Bar-clip versus magnet-retained auricular prostheses: A prospective clinical study with a 3-year follow-up

    Visser, A., Noorda, W. D., Linde, A., Raghoebar, G. M. & Vissink, A., 3-Dec-2019, In : Journal of Prosthetic Dentistry.

    Research output: Contribution to journalArticleAcademicpeer-review

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Datasets
  1. Dataset: Ovalbumin-containing core-shell implants suitable to obtain a delayed IgG1 antibody response in support of a biphasic pulsatile release profile in mice

    Amssoms, K. (Creator), Born, P. (Creator), Beugeling, M. (Creator), De Clerck, B. (Creator), Van Gulck, E. (Creator), Hinrichs, W. (Creator), Frijlink, E. (Creator), Grasmeijer, N. (Creator), Kraus, G. (Creator), Sutmuller, R. (Creator), Simmen, K. (Creator), Baert, L. (Creator), University of Groningen, 17-Aug-2018

    Dataset

  2. Data for: ColiCoords: A Python package for the analysis of bacterial fluorescence microscopy data

    Smit, J. (Creator), Li, Y. (Creator), Warszawik, E. (Creator), Hermann, A. (Creator), Cordes, T. (Creator), University of Groningen, 12-Apr-2019

    Dataset

  3. Data from: Sialendoscopy enhances salivary gland function in Sjögren’s syndrome: a 6 month follow-up, randomized and controlled, single blind study

    Karagozoglu, K. H. (Creator), Vissink, A. (Creator), Forouzanfar, T. (Creator), Brand, H. S. (Creator), Maarse, F. (Creator), Jager, D. (Creator), University of Groningen, 28-Feb-2018

    Dataset

View all (5) »

Prizes
  1. Distinguished Service Award

    Edwin Winkel (Recipient), 2016

    Prize: National/international honourAcademic

  2. VMTI publicatie prijs

    Albert Hoeksema (Recipient), Sophie Spoorenberg (Recipient), Lilian L. Peters (Recipient), Hendrikus Meijer (Recipient), Gerry Raghoebar (Recipient), Arjan Vissink (Recipient), Klaske Wynia (Recipient) & Anita Visser (Recipient), 6-Oct-2017

    PrizeAcademic

View all (23) »

Activities
  1. Nederlandse Vereniging voor Matrix Biologie (Dutch Society for Matirx Biology) (External organisation)

    Janette Burgess (Member)
    May-2019May-2022

    Activity: MembershipMembership of boardProfessional

  2. Netherlands Respiratory Society (NRS) (External organisation)

    Janette Burgess (Member)
    Apr-2019Apr-2022

    Activity: MembershipMembership of boardProfessional

  3. Epigenetic Editing: reprogramming nuclear and mitochondrial gene expression

    Marianne Rots (Speaker)
    20-Jun-2019

    Activity: Talk or presentationAcademic

View all (260) »

Press / Media
  1. Muur rond de hersenen

    Inge Zuhorn

    27/04/2019

    1 Media contribution

    Press/Media: Expert CommentPopular

  2. Interview on Dutch radio station Radio Noord

    Romana Schirhagl

    11/10/2018

    1 Media contribution

    Press/Media: Public Engagement ActivitiesPopular

  3. Voor het eerst extra gen gericht in lichaam gebouwd

    Marianne Rots

    08/10/2018

    1 item of Media coverage

    Press/Media: Expert CommentPopular

View all (30) »

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