Groningen University Institute for Drug Exploration (GUIDE)
University of Groningen > Faculty of Medical Sciences > Groningen University Institute for Drug Exploration (GUIDE)
- Biopharmaceuticals, Discovery, Design and Delivery (BDDD)
- Cardiovascular Centre (CVC)
- Center for Liver, Digestive and Metabolic Diseases (CLDM)
- Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)
- Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI)
- Groningen Institute for Organ Transplantation (GIOT)
- Groningen Kidney Center (GKC)
- Groningen Research Institute for Asthma and COPD (GRIAC)
- Lifestyle Medicine (LM)
- Medicinal Chemistry and Bioanalysis (MCB)
- Microbes in Health and Disease (MHD)
- Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET)
- Translational Immunology Groningen (TRIGR)
Contact information
- Phone: +31 50 363 3163
- Fax: +31 50 363 2612
- E-mail: m.t.l.pekelaer@umcg.nl
Organisational unit profile
Chronic Diseases and Drug Exploration
The Groningen University Institute for Drug Exploration (GUIDE) is based in the University Medical Center Groningen (UMCG) and the Department of Pharmacy (Faculty of Natural Sciences) of the University of Groningen. GUIDE was founded in its present form in 1997. The last reorganization of its research programmes was in 2012. It prepared GUIDE for future international developments such as the new European Framework Programme for Research Horizon2020.
GUIDE performs and stimulates translational, innovative and drug-oriented research on a selected number of (chronic) disease in an interdisciplinary setting. New insight into the pathophysiology of these diseases leads to the development of new drugs and/or treatment options, or optimization of existing therapies (from bench to bed). Alternatively, patient-oriented research is structured in such a way that this leads to new pharmacological concepts (from bed to bench). The research revolves around central themes of the UMCG like Healthy Ageing and Personalized Medicine.
Research Focus and Strategy
Researchers at GUIDE participate in 12 focused research programmes mainly on:
- Lead discovery, development of new drugs, drug delivery and advanced formulation technology
- Translational research on the molecular and cellular mechanisms underlying disease (aetiology and pathophysiology) in relation to treatment of disease, e.g. in the context of clinical trials and by using relevant animal/cell models.
GUIDE is one of the five research institutes of the University Medical Center Groningen and the University of Groningen (RUG). In GUIDE, multidisciplinary teams, situated at the University Medical Center Groningen and the Groningen Research Institute of Pharmacy (GRIP) of the Faculty of Mathematics and Natural Sciences, combine forces, yielding a unique research environment.
Management of GUIDE
The GUIDE management team comprises the scientific director Prof. dr. Dick de Zeeuw and the deputy director Prof. dr. Wim J. Quax. A team of support staff, consisting of two research coordinators and a secretary, supports GUIDE management.
GUIDE is organised in 12 research programmes, which are headed by programme leaders. Programme leaders and GUIDE management meet to discuss research progress and new strategies.
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Prof. D. de Zeeuw, MD/PhD Position: Director | |
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Prof. Wim J. Quax, PhD Position: Deputy Director | |
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Peter G. Braun, PhD Position: Research Coordinator Medical Sciences | |
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Karen E. Voskamp, PhD Position: Research coordinator Pharmaceutical Sciences | |
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Position: Secretary |
Publications
The phenotypic spectrum of proximal 6q deletions based on a large cohort derived from social media and literature reports
Engwerda, A., Frentz, B., den Ouden, A. L., Flapper, B. C. T., Swertz, M. A., Gerkes, E. H., Plantinga, M., Dijkhuizen, T. & van Ravenswaaij-Arts, C. M. A. 8-Jun-2018 In : European Journal of Human Genetics.Research output: Contribution to journal › Article
Small-molecule inhibitors of macrophage migration inhibitory factor (MIF) as an emerging class of therapeutics for immune disorders
Kok, T., Wasiel, A. A., Cool, R. H., Melgert, B. N., Poelarends, G. J. & Dekker, F. J. 21-Jun-2018 In : Drug Discovery Today.Research output: Contribution to journal › Review article
Magnesium and Blood Pressure: A Physiology-Based Approach
Schutten, J. C., Joosten, M. M., de Borst, M. H. & Bakker, S. J. L. May-2018 In : Advances in chronic kidney disease. 25, 3, p. 244-250 7 p.Research output: Contribution to journal › Article
NPHP1 (Nephrocystin-1) Gene Deletions Cause Adult-Onset ESRD
Snoek, R., van Setten, J., Keating, B. J., Israni, A. K., Jacobson, P. A., Oetting, W. S., Matas, A. J., Mannon, R. B., Zhang, Z., Zhang, W., Hao, K., Murphy, B., Reindl-Schwaighofer, R., Heinzl, A., Oberbauer, R., Viklicky, O., Conlon, P. J., Stapleton, C. P., Bakker, S. J. L., Snieder, H., Peters, E. D. J., van der Zwaag, B., Knoers, N. V. A. M., de Borst, M. H. & van Eerde, A. M. Jun-2018 In : Journal of the American Society of Nephrology. 29, 6, p. 1772-1779 8 p.Research output: Contribution to journal › Article
Estimated glomerular filtration rate for longitudinal follow-up of living kidney donors
van Londen, M., Wijninga, A. B., de Vries, J., Sanders, J-S. F., de Jong, M. F. C., Pol, R. A., Berger, S. P., Navis, G. & de Borst, M. H. Jun-2018 In : Nephrology Dialysis Transplantation. 33, 6, p. 1054-1064 11 p.Research output: Contribution to journal › Article
Datasets
Prevention of Renal and Vascular End-stage Disease (PREVEND)
Gansevoort, R. (Creator), University of Groningen, 2017
Dataset
Parel Infammatory Bowel Disease (IBD)
Dijkstra, G. (Creator), Lowenberg, M. (Creator), University of Groningen, 2017
http://www.parelsnoer.org/page/nl/De-onderzoeker/Aanvraag-onderzoeksgegevens
Dataset
Vlagtwedde-Vlaardingen Study (VlaVla)
Boezen, H. (Creator), VANDERLENDE, R. (Creator), University of Groningen, 1990
https://www.umcg.nl/EN/Research/Researchers/Facilities/biobanks/biobanks/Vlagtwedde-Vlaardingen/paginas/default.aspx and one more link, https://kennisinzicht.umcg.nl/Paginas/Een-scala-aan-tests-en-prikjes.aspx (show fewer)
Dataset
Prizes
Selection of publication as top 10 publication in the field of eczema
Gerard Koppelman (Recipient), 7-May-2018
Prize: Other distinction
Best abstract Respiratory Effectiveness Group Summit 2018
Boudewijn Dierick (Recipient), Bertine Flokstra-de Blok (Recipient), Thys van der Molen (Recipient), Nuria Toledo Pons (Recipient), Miguel Román Rodriguez (Recipient), Borja G Cosío (Recipient), Joan B. Soriano (Recipient), Job Boven, van (Recipient) & Janwillem Kocks (Recipient), Apr-2018
Prize
Activities
NVGCT Nederlandse Vereniging voor Gen- en Celtherapie (External organisation)
Daemen, T. (Member)2018 → 2020Activity: Scientific › Membership of committee
Pharmacy Day 2018
Salvati, A. (Organiser), Dolga, A. (Organiser), Groves, M. (Organiser), Mathwig, K. (Organiser), Horvatovich, P. (Organiser), Quax, W. (Organiser), Lexmond, A. (Organiser), Nieuwenhuis-Dempsey, G. (Organiser)12-Jun-2018Activity: Scientific › Organising an event
Euroanaesthesia 2018
Absalom, A. (Invited speaker)2-Jun-2018Activity: Scientific › Participation in conference
Press / Media
Onverklaarbare epidemie van vleesetende zweren in Australie
17/04/2018
1 item of media coverage
Press/Media: Public Engagement Activities
ID: 34632