Groningen University Institute for Drug Exploration (GUIDE)
- Biopharmaceuticals, Discovery, Design and Delivery (BDDD)
- Cardiovascular Centre (CVC)
- Center for Liver, Digestive and Metabolic Diseases (CLDM)
- Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)
- Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI)
- Groningen Institute for Organ Transplantation (GIOT)
- Groningen Kidney Center (GKC)
- Groningen Research Institute for Asthma and COPD (GRIAC)
- Lifestyle Medicine (LM)
- Medicinal Chemistry and Bioanalysis (MCB)
- Microbes in Health and Disease (MHD)
- Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET)
- Translational Immunology Groningen (TRIGR)
- Phone: +31 50 363 3163
- Fax: +31 50 363 2612
- E-mail: firstname.lastname@example.org
Organisational unit profile
Chronic Diseases and Drug Exploration
The Groningen University Institute for Drug Exploration (GUIDE) is based in the University Medical Center Groningen (UMCG) and the Department of Pharmacy (Faculty of Natural Sciences) of the University of Groningen. GUIDE was founded in its present form in 1997. The last reorganization of its research programmes was in 2012. It prepared GUIDE for future international developments such as the new European Framework Programme for Research Horizon2020.
GUIDE performs and stimulates translational, innovative and drug-oriented research on a selected number of (chronic) disease in an interdisciplinary setting. New insight into the pathophysiology of these diseases leads to the development of new drugs and/or treatment options, or optimization of existing therapies (from bench to bed). Alternatively, patient-oriented research is structured in such a way that this leads to new pharmacological concepts (from bed to bench). The research revolves around central themes of the UMCG like Healthy Ageing and Personalized Medicine.
Research Focus and Strategy
Researchers at GUIDE participate in 12 focused research programmes mainly on:
- Lead discovery, development of new drugs, drug delivery and advanced formulation technology
- Translational research on the molecular and cellular mechanisms underlying disease (aetiology and pathophysiology) in relation to treatment of disease, e.g. in the context of clinical trials and by using relevant animal/cell models.
GUIDE is one of the five research institutes of the University Medical Center Groningen and the University of Groningen (RUG). In GUIDE, multidisciplinary teams, situated at the University Medical Center Groningen and the Groningen Research Institute of Pharmacy (GRIP) of the Faculty of Mathematics and Natural Sciences, combine forces, yielding a unique research environment.
Management of GUIDE
The GUIDE management team comprises the scientific director Prof. dr. Dick de Zeeuw and the deputy director Prof. dr. Wim J. Quax. A team of support staff, consisting of two research coordinators and a secretary, supports GUIDE management.
GUIDE is organised in 12 research programmes, which are headed by programme leaders. Programme leaders and GUIDE management meet to discuss research progress and new strategies.
Prof. D. de Zeeuw, MD/PhD
Prof. Wim J. Quax, PhD
Position: Deputy Director
Peter G. Braun, PhD
Position: Research Coordinator Medical Sciences
Karen E. Voskamp, PhD
Position: Research coordinator Pharmaceutical Sciences
Adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): final results of an international, open-label, multicentre, randomised, phase 3 trialde Boer, S. M., Powell, M. E., Mileshkin, L., Katsaros, D., Bessette, P., Haie-Meder, C., Ottevanger, P. B., Ledermann, J. A., Khaw, P., Colombo, A., Fyles, A., Baron, M-H., Jürgenliemk-Schulz, I. M., Kitchener, H. C., Nijman, H. W., Wilson, G., Brooks, S., Carinelli, S., Provencher, D., Hanzen, C., Lutgens, L. C. H. W., Smit, V. T. H. B. M., Singh, N., Do, V., D'Amico, R., Nout, R. A., Feeney, A., Verhoeven-Adema, K. W., Putter, H., Creutzberg, C. L. & PORTEC study group 12-Feb-2018 In : Lancet Oncology.
Research output: Scientific - peer-review › Article
Potential Red-Flag Identification of Colorectal Adenomas with Wide-Field Fluorescence Molecular EndoscopyHartmans, E., Tjalma, J. J. J., Linssen, M. D., Allende, P. B. G., Koller, M., Jorritsma-Smit, A., Nery, M. E. S. D. O., Elias, S. G., Karrenbeld, A., de Vries, E. G. E., Kleibeuker, J. H., van Dam, G. M., Robinson, D. J., Ntziachristos, V. & Nagengast, W. B. 2018 In : Theranostics. 8, 6, p. 1458-1467 10 p.
Research output: Scientific - peer-review › Article
COMPLIANCE TO ADJUVANT TREATMENT GUIDELINES IN ENDOMETRIAL CANCER: ROOM FOR IMPROVEMENT IN HIGH RISK PATIENTSEggink, F. A., Mom, C. H., Boll, D., Ezendam, N. P., Kruitwagen, R. F., Pijnenborg, J. M., Van der Aa, M. A. & Nijman, H. W. Nov-2017 In : International Journal of Gynecological Cancer. 27, p. 1079-1079 1 p.
Research output: Scientific › Meeting Abstract
- Proost, J. 2017 Total Intravenous Anesthesia and Target Controlled Infusions: A Comprehensive Global Anthology. Absalom, A. R. & Mason, K. P. (eds.). Springer, p. 117-145
Research output: Professional › Chapter
Member of the search committee for a new director of the Groningen Research Institute of Pharmacy (GRIP) (External organisation)Poelarends, G. (Member)2016
Activity: Scientific › Membership of committee
- Poelarends, G. (Member)2007 → 2020
Activity: Scientific › Membership of network
Press / Media
1 media contribution
Press / Media: Expert Comment