1. 2017
  2. Abdelraheem, E. M. M., Madhavachary, R., Rossetti, A., Kurpiewska, K., Kalinowska-Tłuścik, J., Shaabani, S., & Dömling, A. (2017). Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings. Organic letters, 19(22), 6176-6179. DOI: 10.1021/acs.orglett.7b03094
  3. Magiera-Mularz, K., Skalniak, L., Zak, K. M., Musielak, B., Rudzinska-Szostak, E., Berlicki, Ł., ... Holak, T. A. (2017). Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint. Angewandte Chemie - International Edition, 56(44), 13732-13735. DOI: 10.1002/anie.201707707
  4. Estrada-Ortiz, N., Neochoritis, C. G., Twarda-Clapa, A., Musielak, B., Holak, T. A., & Dömling, A. (2017). Artificial Macrocycles as Potent p53-MDM2 Inhibitors. Bioorganic & Medicinal Chemistry Letters, 8(10), 1025-1030. DOI: 10.1021/acsmedchemlett.7b00219
  5. Skalniak, L., Zak, K. M., Guzik, K., Magiera, K., Musielak, B., Pachota, M., ... Holak, T. A. (2017). Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells. Oncotarget, 8(42), 72167-72181. DOI: 10.18632/oncotarget.20050
  6. Abdelraheem, E. M. M., de Haan, M. P., Patil, P., Kurpiewska, K., Kalinowska-Tłuścik, J., Shaabani, S., & Dömling, A. (2017). Concise Synthesis of Tetrazole Macrocycle. Organic letters, 19, 5078-5081. DOI: 10.1021/acs.orglett.7b02319
  7. Magiera, K., Zak, K., Berlicki, L., Domling, A., Holak, T., & Dubin, G. (2017). Structural basis of PD-1/PD-L1 checkpoint inhibition. Febs Journal, 284, 45-45.
  8. Madhavachary, R., Abdelraheem, E. M. M., Rossetti, A., Twarda-Clapa, A., Musielak, B., Kurpiewska, K., ... Dömling, A. (2017). Two-Step Synthesis of Complex Artificial Macrocyclic Compounds. Angewandte Chemie - International Edition, 56(36), 10725-10729. DOI: 10.1002/anie.201704426
  9. Zak, K. M., Grudnik, P., Magiera, K., Dömling, A., Dubin, G., & Holak, T. A. (2017). Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2. Structure, 25(8), 1163-1174. DOI: 10.1016/j.str.2017.06.011
  10. Twarda-Clapa, A., Krzanik, S., Kubica, K., Guzik, K., Labuzek, B., Neochoritis, C. G., ... Holak, T. A. (2017). 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. Journal of Medicinal Chemistry, 60(10), 4234-4244. DOI: 10.1021/acs.jmedchem.7b00104
  11. Shaabani, S., Neochoritis, C. G., Twarda-Clapa, A., Musielak, B., Holak, T. A., & Domling, A. (2017). Scaffold hopping via ANCHOR.QUERY: beta-lactams as potent p53-MDM2 antagonists. MedChemCommun, 8(5), 1046-1052. DOI: 10.1039/c7md00058h
  12. Wang, Y., Patil, P., Kurpiewska, K., Kalinowska-Tluscik, J., & Domling, A. (2017). Two Cycles with One Catch: Hydrazine in Ugi 4-CR and Its Postcyclizations. Acs combinatorial science, 19(3), 193-198. DOI: 10.1021/acscombsci.7b00009
  13. Patil, P., Madhavachary, R., Kurpiewska, K., Kalinowska-Tłuścik, J., & Dömling, A. (2017). De Novo Assembly of Highly Substituted Morpholines and Piperazines. Organic letters, 19(3), 642-645. DOI: 10.1021/acs.orglett.6b03807
  14. Kroon, E. (2017). Exploring multicomponent reactions: From chemistry to drug design [Groningen]: Rijksuniversiteit Groningen
  15. Zarganes Tzitzikas, T. (2017). Innovative multicomponent reactions and their use in medicinal chemistry [Groningen]: University of Groningen
  16. Chandgude, A. (2017). Multicomponent reactions: development, scope, and applications [Groningen]: University of Groningen
  17. 2016
  18. Surmiak, E., Twarda-Clapa, A., Zak, K. M., Musielak, B., Tomala, M. D., Kubica, K., ... Holak, T. A. (2016). A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction. ACS chemical biology, 11(12), 3310-3318. DOI: 10.1021/acschembio.6b00596
  19. Livadiotou, D., Hatzimimikou, D., Tsitsi, D., Tsiaras, V., Samatidou, E., & Neochoritis, C. (2016). One-pot reaction of pyranoindolones with phenylisocyanates: a simple and regioselective approach to b-carbolines. Tetrahedron Letters, 57(49), 5453-5456. DOI: 10.1016/j.tetlet.2016.10.075
  20. Fuggetta, M. P., De Mico, A., Cottarelli, A., Morelli, F., Zonfrillo, M., Ulgheri, F., ... Spanu, P. (2016). Synthesis and Enantiomeric Separation of a Novel Spiroketal Derivative: A Potent Human Telomerase Inhibitor with High in Vitro Anticancer Activity. Journal of Medicinal Chemistry, 59(19), 9140-9149. DOI: 10.1021/acs.jmedchem.6b01046
  21. Zak, K. M., Grudnik, P., Guzik, K., Zieba, B. J., Musielak, B., Dömling, A., ... Holak, T. A. (2016). Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1). Oncotarget, 7(21), 30323-30335. DOI: 10.18632/oncotarget.8730
  22. Boltjes, A., Shrinidhi, A., van de Kolk, K., Herdtweck, E., & Dömling, A. (2016). Gd-TEMDO: Design, Synthesis, and MRI Application. Chemistry, 22(22), 7352-7356. DOI: 10.1002/chem.201600720
  23. Patil, P., Zhang, J., Kurpiewska, K., Kalinowska-Tłuścik, J., & Dömling, A. (2016). Hydrazine in the Ugi Tetrazole Reaction. Synthesis, 48(8), 1122-1130. DOI: 10.1055/s-0035-1561353
  24. Zhao, T., Kurpiewska, K., Kalinowska-Tłuścik, J., Herdtweck, E., & Dömling, A. (2016). α-Amino Acid-Isosteric α-Amino Tetrazoles. Chemistry, 22(9), 3009-3018. DOI: 10.1002/chem.201504520
  25. Kroon, E., Kurpiewska, K., Kalinowska-Tłuścik, J., & Dömling, A. (2016). Cleavable β-Cyanoethyl Isocyanide in the Ugi Tetrazole Reaction. Organic letters, 18(19), 4762-4765. DOI: 10.1021/acs.orglett.6b01826
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