Cancer Research Center Groningen (CRCG)
University of Groningen > Faculty of Medical Sciences > Cancer Research Center Groningen (CRCG)
Contact information
- Phone: +31 50 363 4734
- E-mail: crcg@umcg.nl
Organisational unit profile
Fundamental, Clinical and Translational Cancer Research.
The Cancer Research Center Groningen (CRCG) was established in 2012. The aim is to translate fundamental insights in oncogenesis and tumour behaviour from basic research into cancer prevention, improvement of early detection of cancer, and better treatment for cancer patients.
The mission of the CRCG is to clarify the molecular mechanisms that determine malignant transformation in a broad spectrum of tumors and to translate these fundamental insights into improved early detection and treatment of cancers. This will ultimately lead to personalized cancer therapy, thus reducing the unintended side effects of treatment on normal tissues and improving the quality of life of cancer survivors.
The CRCG was founded in 2012 as an independent research institute of the University Medical Center Groningen. Four key research programmes have been established:
- Damage and Repair in Cancer Development and Cancer Treatment (DARE);
- Guided Treatment in optimal Selected cancer patientsTranslational and Clinical research in Oncology (GUTS);
- Stem cells, Aging, Leukemia and Lymphoma (SALL);
- TARgeted Gynaecologic Oncology (TARGON).
These programmes are supported by 60 PIs and 139 PhD or MD/PhD students who participate in the UMCG’s Graduate School of Medical Sciences (GSMS). The various programs are characterized by a strong interaction between basic and translational research programs, as shown by joint research meetings and projects.
Publications
Lactate dehydrogenase levels and F-18-FDG PET/CT metrics differentiate between mediastinal Hodgkin's lymphoma and primary mediastinal B-cell lymphoma
Alkhawtani, R. H. M., Noordzij, W., Glaudemans, A. W. J. M., van Rijn, R. S., van der Galien, H. T., Balink, H., Nijland, M., Adams, H. J. A., Huls, G., van Meerten, T. & Kwee, T. C. Jun-2018 In : Nuclear Medicine Communications. 39, 6, p. 572-578 7 p.Research output: Contribution to journal › Article
Circulating Haptoglobin and Metabolic Syndrome in Renal Transplant Recipients (vol 7, 14264, 2017)
Minovic, I., Eisenga, M. F., Riphagen, I. J., van den Berg, E., Kootstra-Ros, J., Frenay, A-R. S., van Goor, H., Rimbach, G., Esatbeyoglu, T., Levy, A. P., Gaillard, C. A. J. M., Geleijnse, J. M., Eggersdorfer, M. L., Navis, G. J., Kema, I. P. & Bakker, S. J. L. 20-Apr-2018 In : Scientific Reports. 8, 1 p., 6501Research output: Contribution to journal › Article
Influence of prednisolone on parameters of de novo lipogenesis and indices for stearoyl-CoA- and Delta 6-desaturase activity in healthy males: A Post-hoc analysis of a randomized, placebo-controlled, double-blind trial
Pranger, I. G., van Raalte, D. H., Brands, M., Muskiet, M. H. A., Kema, I. P., Serlie, M. J., Diamant, M., Bakker, S. J. L. & Muskiet, F. A. J. May-2018 In : Prostaglandins Leukotrienes and Essential Fatty Acids. 132, p. 8-15 8 p.Research output: Contribution to journal › Article
Combined HAT/EZH2 modulation leads to cancer-selective cell death
Petraglia, F., Singh, A. A., Carafa, V., Nebbioso, A., Conte, M., Scisciola, L., Valente, S., Baldi, A., Mandoli, A., Petrizzi, V. B., Ingenito, C., De Falco, S., Cicatiello, V., Apicella, I., Janssen-Megens, E. M., Kim, B., Yi, G., Logie, C., Heath, S., Ruvo, M., Wierenga, A. T. J., Flicek, P., Yaspo, M. L., Della Valle, V., Bernard, O., Tomassi, S., Novellino, E., Feoli, A., Sbardella, G., Gut, I., Vellenga, E., Stunnenberg, H. G., Mai, A., Martens, J. H. A. & Altucci, L. 2018 In : Oncotarget. 9, 39, p. 25630-25646 17 p.Research output: Contribution to journal › Article
Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia
Singh, A. A., Petraglia, F., Nebbioso, A., Yi, G., Conte, M., Valente, S., Mandoli, A., Scisciola, L., Lindeboom, R., Kerstens, H., Janssen-Megens, E. M., Pourfarzad, F., Habibi, E., Berentsen, K., Kim, B., Logie, C., Heath, S., Wierenga, A. T. J., Clarke, L., Flicek, P., Jansen, J. H., Kuijpers, T., Yaspo, M. L., Valle, V. D., Bernard, O., Gut, I., Vellenga, E., Stunnenberg, H. G., Mai, A., Altucci, L. & Martens, J. H. A. 2018 In : Oncotarget. 9, 39, p. 25647-25660 14 p.Research output: Contribution to journal › Article
Datasets
Inhibition of the miR-155 target NIAM phenocopies the growth promoting effect of miR-155 in B-cell lymphoma [L1236]
Kluiver, J. (Creator), Slezak, I. (Creator), Berg, van den, A. (Creator), NCBI, 16-Jul-2015
http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE70937
Dataset
Prizes
Understanding the cause of ataxia in the DNA repair deficiency syndrome Ataxia Telangiectasia: a possible link between DNA damage and proteostasis
Steven Bergink (Recipient), 2013
Prize: Fellowship awarded competitively
Activities
Lung education series:
Schuuring, E. (Invited speaker)1-Dec-2017 → 2-Dec-2017Activity: Scientific › Organising an event
European Computer Assisted Liver Surgery Society (ECALSS) (External organisation)
Jong, de, K. (Member)24-Nov-2012 → …Activity: Professional › Membership of board
Press / Media
Nieuwe ontwikkelingen in hematologie, MDS, AML, translationeel.
22/11/2017
1 media contribution
Press/Media: Public Engagement Activities
Experimentele hematologie verfijnt kijk op leukemie
01/10/2017
1 item of media coverage
Press/Media: Public Engagement Activities
ID: 12296270