Cancer Research Center Groningen (CRCG)

University of Groningen > Faculteit Medische Wetenschappen/UMCG > Cancer Research Center Groningen (CRCG)

Contact information

Ant. Deusinglaan 1
Building 3217 ('de Brug'), Room 7.21
9713 AV
  • Phone: +31 50 363 4734

Organisational unit profile

Fundamental, Clinical and Translational Cancer Research.
The Cancer Research Center Groningen (CRCG) was established in 2012. The aim is to translate fundamental insights in oncogenesis and tumour behaviour from basic research into cancer prevention, improvement of early detection of cancer, and better treatment for cancer patients.

The mission of the CRCG is to clarify the molecular mechanisms that determine malignant transformation in a broad spectrum of tumors and to translate these fundamental insights into improved early detection and treatment of cancers. This will ultimately lead to personalized cancer therapy, thus reducing the unintended side effects of treatment on normal tissues and improving the quality of life of cancer survivors.

The CRCG was founded in 2012 as an independent research institute of the University Medical Center Groningen. Four key research programmes have been established:

  1. Damage and Repair in Cancer Development and Cancer Treatment (DARE);
  2. Guided Treatment in optimal Selected cancer patientsTranslational and Clinical research in Oncology (GUTS);
  3. Stem cells, Aging, Leukemia and Lymphoma (SALL);
  4. TARgeted Gynaecologic Oncology  (TARGON).

These programmes are supported by 60 PIs and 139 PhD or MD/PhD students who participate in the UMCG’s Graduate School of Medical Sciences (GSMS). The various programs are characterized by a strong interaction between basic and translational research programs, as shown by joint research meetings and projects.

  1. Senescent Cells: A Potential Target for New Cancer Therapies in Older Oncologic Patients

    Brattinga, B. & van Leeuwen, B. L., 13-Jan-2021, In : Cancers. 13, 2, 2 p., 278.

    Research output: Contribution to journalEditorialAcademicpeer-review

  2. PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis

    Sladky, V. C., Knapp, K., Szabo, T. G., Braun, V. Z., Bongiovanni, L., van den Bos, H., Spierings, D. C. J., Westendorp, B., Curinha, A., Stojakovic, T., Scharnagl, H., Timelthaler, G., Tsuchia, K., Pinter, M., Semmler, G., Foijer, F., de Bruin, A., Reiberger, T., Rohr-Udilova, N. & Villunger, A., 3-Dec-2020, In : Embo Reports. 21, 12, 16 p., 50893.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. A novel mouse model for pyridoxine-dependent epilepsy due to antiquitin deficiency

    Al-Shekaili, H. H., Petkau, T. L., Pena, I., Lengyell, T. C., Verhoeven-Duif, N. M., Ciapaite, J., Bosma, M., van Faassen, M., Kema, I. P., Horvath, G., Ross, C., Simpson, E. M., Friedman, J. M., van Karnebeek, C. & Leavitt, B. R., 25-Nov-2020, In : Human Molecular Genetics. 29, 19, p. 3266-3284 19 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Can we use the same planning strategies for diaphragm motion in IMPT as we use in VMAT?

    Visser, S., Neh, H., Ribeiro, C. O., Korevaar, E., Meijers, A., Poppe, B., Both, S., Langendijk, J. A., Muijs, C. T. & Knopf, A., Nov-2020, In : Radiotherapy and Oncology. 152, Suppl 1, S431.

    Research output: Contribution to journalMeeting AbstractAcademic

View all (9,403) »

  1. Dataset: Total Body Metabolic Tumor Response in ALK Positive Non-Small Cell Lung Cancer Patients Treated with ALK Inhibition

    Kerner, G. (Creator), Koole, M. J. B. (Creator), Bongaerts, A. H. H. (Creator), Pruim, J. (Creator) & Groen, H. (Creator), University of Groningen, 23-Apr-2016


  2. Data: Direct chromosome-length haplotyping by single-cell sequencing

    Lansdorp, P. (Creator), Sanders, A. D. (Creator), van Wietmarschen, N. (Creator), Falconer, E. (Creator), Hills, M. (Creator), Spierings, D. (Creator), Bevova, M. (Creator) & Guryev, V. (Creator), University of Groningen, 26-Nov-2016


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  1. AIHS Visiting Scientist Award

    Bremer, Edwin (Recipient), 2013


  2. ZonMW-VIDI Committee

    Rots, Marianne (Recipient), 2020

    Prize: AppointmentAcademic

  3. Management Committee International Nucleome Consortium

    Rots, Marianne (Recipient), 2020

    Prize: National/international honourAcademic

View all (39) »

  1. The 62nd American Society of Hematology (ASH)

    Edwin Bremer (Invited speaker)


    Activity: Participating in or organising an eventParticipation in conferenceAcademic

  2. Kahr Med (External organisation)

    Edwin Bremer (Member)

    Mar-2018 → …

    Activity: MembershipMembership of boardAcademic

  3. Cancers (Journal)

    Edwin Bremer (Editorial board member)

    2020 → …

    Activity: Publication peer-review and editorial workEditorial activityAcademic

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Press / Media
  1. Annexin Pharmaceuticals AB initiates collaboration with TRACER for imaging studies

    Go van Dam


    3 Media contributions

    Press/Media: Expert CommentPopular

  2. De vrouw doet met een kleiner brein niet onder voor de man

    Iris Sommer


    4 Media contributions

    Press/Media: Expert CommentPopular

  3. UMCG onderzoekt of patiënten voor 'eenvoudige' operaties naar Duitsland kunnen

    Ate van der Zee


    1 Media contribution

    Press/Media: Expert CommentPopular

View all (152) »

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