Cancer Research Center Groningen (CRCG)
University of Groningen > Faculteit Medische Wetenschappen/UMCG > Cancer Research Center Groningen (CRCG)
Contact information
- Phone: +31 50 363 4734
- E-mail: crcg@umcg.nl
Organisational unit profile
Fundamental, Clinical and Translational Cancer Research.
The Cancer Research Center Groningen (CRCG) was established in 2012. The aim is to translate fundamental insights in oncogenesis and tumour behaviour from basic research into cancer prevention, improvement of early detection of cancer, and better treatment for cancer patients.
The mission of the CRCG is to clarify the molecular mechanisms that determine malignant transformation in a broad spectrum of tumors and to translate these fundamental insights into improved early detection and treatment of cancers. This will ultimately lead to personalized cancer therapy, thus reducing the unintended side effects of treatment on normal tissues and improving the quality of life of cancer survivors.
The CRCG was founded in 2012 as an independent research institute of the University Medical Center Groningen. Four key research programmes have been established:
- Damage and Repair in Cancer Development and Cancer Treatment (DARE);
- Guided Treatment in optimal Selected cancer patientsTranslational and Clinical research in Oncology (GUTS);
- Stem cells, Aging, Leukemia and Lymphoma (SALL);
- TARgeted Gynaecologic Oncology (TARGON).
These programmes are supported by 60 PIs and 139 PhD or MD/PhD students who participate in the UMCG’s Graduate School of Medical Sciences (GSMS). The various programs are characterized by a strong interaction between basic and translational research programs, as shown by joint research meetings and projects.
Publications
Senescent Cells: A Potential Target for New Cancer Therapies in Older Oncologic Patients
Brattinga, B. & van Leeuwen, B. L., 13-Jan-2021, In : Cancers. 13, 2, 2 p., 278.Research output: Contribution to journal › Editorial › Academic › peer-review
Technical Note: First report on an in vivo range probing quality control procedure for scanned proton beam therapy in head and neck cancer patients
Meijers, A., Seller Oria, C., Free, J., Langendijk, J. A., Knopf, A. C. & Both, S., 11-Jan-2021, In : Medical Physics.Research output: Contribution to journal › Article › Academic › peer-review
PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis
Sladky, V. C., Knapp, K., Szabo, T. G., Braun, V. Z., Bongiovanni, L., van den Bos, H., Spierings, D. C. J., Westendorp, B., Curinha, A., Stojakovic, T., Scharnagl, H., Timelthaler, G., Tsuchia, K., Pinter, M., Semmler, G., Foijer, F., de Bruin, A., Reiberger, T., Rohr-Udilova, N. & Villunger, A., 3-Dec-2020, In : Embo Reports. 21, 12, 16 p., 50893.Research output: Contribution to journal › Article › Academic › peer-review
A novel mouse model for pyridoxine-dependent epilepsy due to antiquitin deficiency
Al-Shekaili, H. H., Petkau, T. L., Pena, I., Lengyell, T. C., Verhoeven-Duif, N. M., Ciapaite, J., Bosma, M., van Faassen, M., Kema, I. P., Horvath, G., Ross, C., Simpson, E. M., Friedman, J. M., van Karnebeek, C. & Leavitt, B. R., 25-Nov-2020, In : Human Molecular Genetics. 29, 19, p. 3266-3284 19 p.Research output: Contribution to journal › Article › Academic › peer-review
Can we use the same planning strategies for diaphragm motion in IMPT as we use in VMAT?
Visser, S., Neh, H., Ribeiro, C. O., Korevaar, E., Meijers, A., Poppe, B., Both, S., Langendijk, J. A., Muijs, C. T. & Knopf, A., Nov-2020, In : Radiotherapy and Oncology. 152, Suppl 1, S431.Research output: Contribution to journal › Meeting Abstract › Academic
Datasets
Replication data to: Cortisol and α-amylase secretion patterns between and within depressed and non-depressed individuals.
Booij, S. (Creator), Bos, E. (Creator), Bouwmans, M. (Creator), Faassen, van, M. (Contributor), Kema, I. (Creator), Oldehinkel, T. (Contributor) & Jonge, de, P. (Supervisor), University of Groningen, 6-Jul-2015
DOI: https://doi.org/10411/C8LWAC, https://doi.org/10.1371/journal.pone.0131002.s013
Dataset
Dataset: Total Body Metabolic Tumor Response in ALK Positive Non-Small Cell Lung Cancer Patients Treated with ALK Inhibition
Kerner, G. (Creator), Koole, M. J. B. (Creator), Bongaerts, A. H. H. (Creator), Pruim, J. (Creator) & Groen, H. (Creator), University of Groningen, 23-Apr-2016
DOI: https://doi.org/10.6084/m9.figshare.3189766.v1
Dataset
Data: Direct chromosome-length haplotyping by single-cell sequencing
Lansdorp, P. (Creator), Sanders, A. D. (Creator), van Wietmarschen, N. (Creator), Falconer, E. (Creator), Hills, M. (Creator), Spierings, D. (Creator), Bevova, M. (Creator) & Guryev, V. (Creator), University of Groningen, 26-Nov-2016
DOI: https://doi.org/10.5281/zenodo.599901
Dataset
Prizes
Management Committee International Nucleome Consortium
Rots, Marianne (Recipient), 2020
Prize: National/international honour › Academic
Activities
The 62nd American Society of Hematology (ASH)
Edwin Bremer (Invited speaker)
5-Dec-2020Activity: Participating in or organising an event › Participation in conference › Academic
Kahr Med (External organisation)
Edwin Bremer (Member)
Mar-2018 → …Activity: Membership › Membership of board › Academic
Cancers (Journal)
Edwin Bremer (Editorial board member)
2020 → …Activity: Publication peer-review and editorial work › Editorial activity › Academic
Press / Media
Annexin Pharmaceuticals AB initiates collaboration with TRACER for imaging studies
10/12/2020
3 Media contributions
Press/Media: Expert Comment › Popular
De vrouw doet met een kleiner brein niet onder voor de man
23/10/2020 → 06/12/2020
4 Media contributions
Press/Media: Expert Comment › Popular
UMCG onderzoekt of patiënten voor 'eenvoudige' operaties naar Duitsland kunnen
30/11/2020
1 Media contribution
Press/Media: Expert Comment › Popular
ID: 12296270