Cancer Research Center Groningen (CRCG)

University of Groningen > Faculteit Medische Wetenschappen/UMCG > Cancer Research Center Groningen (CRCG)

Contact information

Ant. Deusinglaan 1
Building 3217 ('de Brug'), Room 7.21
9713 AV
  • Phone: +31 50 363 4734

Organisational unit profile

Fundamental, Clinical and Translational Cancer Research.
The Cancer Research Center Groningen (CRCG) was established in 2012. The aim is to translate fundamental insights in oncogenesis and tumour behaviour from basic research into cancer prevention, improvement of early detection of cancer, and better treatment for cancer patients.

The mission of the CRCG is to clarify the molecular mechanisms that determine malignant transformation in a broad spectrum of tumors and to translate these fundamental insights into improved early detection and treatment of cancers. This will ultimately lead to personalized cancer therapy, thus reducing the unintended side effects of treatment on normal tissues and improving the quality of life of cancer survivors.

The CRCG was founded in 2012 as an independent research institute of the University Medical Center Groningen. Four key research programmes have been established:

  1. Damage and Repair in Cancer Development and Cancer Treatment (DARE);
  2. Guided Treatment in optimal Selected cancer patientsTranslational and Clinical research in Oncology (GUTS);
  3. Stem cells, Aging, Leukemia and Lymphoma (SALL);
  4. TARgeted Gynaecologic Oncology  (TARGON).

These programmes are supported by 60 PIs and 139 PhD or MD/PhD students who participate in the UMCG’s Graduate School of Medical Sciences (GSMS). The various programs are characterized by a strong interaction between basic and translational research programs, as shown by joint research meetings and projects.

  1. Positron Emission Tomography (PET) Imaging of Opioid Receptors

    van Waarde, A., Absalom, T., Visser, A. K. D. & Dierckx, R., Aug-2020, (Accepted/In press) PET and SPECT of Neurobiological Systems. Dierckx, R., Otte, A., de Vries, E., van Waarde, A. & Lammertsma, A. (eds.). 2 ed. Heidelberg: Springer Nature, 61 p.

    Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

  2. Dexamethasone for the Prevention of a Pain Flare After Palliative Radiation Therapy for Painful Bone Metastases: The Multicenter Double-Blind Placebo-Controlled 3-Armed Randomized Dutch DEXA Study

    van der Linden, Y. M., Westhoff, P. G., Stellato, R. K., van Baardwijk, A., de Vries, K., Ong, F., Wiggenraad, R., Bakri, B., Wester, G., de Pree, I., van Veelen, L., Budiharto, T., Schippers, M., Reyners, A. K. L. & de Graeff, A., 22-May-2020, In : International Journal of Radiation Oncology, Biology, Physics. 8 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

    Dominguez-Valentin, M., Sampson, J. R., Seppälä, T. T., Ten Broeke, S. W., Plazzer, J-P., Nakken, S., Engel, C., Aretz, S., Jenkins, M. A., Sunde, L., Bernstein, I., Capella, G., Balaguer, F., Thomas, H., Evans, D. G., Burn, J., Greenblatt, M., Hovig, E., de Vos Tot Nederveen Cappel, W. H., Sijmons, R. H., Bertario, L., Tibiletti, M. G., Cavestro, G. M., Lindblom, A., Della Valle, A., Lopez-Köstner, F., Gluck, N., Katz, L. H., Heinimann, K., Vaccaro, C. A., Büttner, R., Görgens, H., Holinski-Feder, E., Morak, M., Holzapfel, S., Hüneburg, R., Knebel Doeberitz, M. V., Loeffler, M., Rahner, N., Schackert, H. K., Steinke-Lange, V., Schmiegel, W., Vangala, D., Pylvänäinen, K., Renkonen-Sinisalo, L., Hopper, J. L., Win, A. K., Haile, R. W., Lindor, N. M., Gallinger, S., Le Marchand, L., Newcomb, P. A., Figueiredo, J. C., Thibodeau, S. N., Wadt, K., Therkildsen, C., Okkels, H., Ketabi, Z., Moreira, L., Sánchez, A., Serra-Burriel, M., Pineda, M., Navarro, M., Blanco, I., Green, K., Lalloo, F., Crosbie, E. J., Hill, J., Denton, O. G., Frayling, I. M., Rødland, E. A., Vasen, H., Mints, M., Neffa, F., Esperon, P., Alvarez, K., Kariv, R., Rosner, G., Pinero, T. A., Gonzalez, M. L., Kalfayan, P., Tjandra, D., Winship, I. M., Macrae, F., Möslein, G., Mecklin, J-P., Nielsen, M. & Møller, P., 20-Jul-2020, In : Genetics in Medicine.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Cellular senescence impairs the reversibility of pulmonary arterial hypertension

    van der Feen, D. E., Bossers, G. P. L., Hagdorn, Q. A. J., Moonen, J-R., Kurakula, K., Szulcek, R., Chappell, J., Vallania, F., Donato, M., Kok, K., Kohli, J. S., Petersen, A. H., van Leusden, T., Demaria, M., Goumans, M-J. T. H., De Boer, R. A., Khatri, P., Rabinovitch, M., Berger, R. M. F. & Bartelds, B., 29-Jul-2020, In : Science Translational Medicine. 12, 554

    Research output: Contribution to journalArticleAcademicpeer-review

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  1. Dataset: Total Body Metabolic Tumor Response in ALK Positive Non-Small Cell Lung Cancer Patients Treated with ALK Inhibition

    Kerner, G. (Creator), Koole, M. J. B. (Creator), Bongaerts, A. H. H. (Creator), Pruim, J. (Creator), Groen, H. (Creator), University of Groningen, 23-Apr-2016


  2. Data: Direct chromosome-length haplotyping by single-cell sequencing

    Lansdorp, P. (Creator), Sanders, A. D. (Creator), van Wietmarschen, N. (Creator), Falconer, E. (Creator), Hills, M. (Creator), Spierings, D. (Creator), Bevova, M. (Creator), Guryev, V. (Creator), University of Groningen, 26-Nov-2016


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  1. Jaarprijs Palliatieve Zorg Impact

    An Reyners (Recipient), 10-Oct-2019


  2. ZonMW Parel

    An Reyners (Recipient), 15-Nov-2019


  3. Consultant at Sangamo Therapeutics Inc

    Marianne Rots (Recipient), 2019

    Prize: National/international honourProfessional

View all (34) »

  1. Oncologiedagen voor Nederland en Vlaanderen 24e editie

    An Reyners (Speaker)

    Activity: Talk or presentationPopular

  2. 21e Nederlands-Vlaams Doelencongres Infertiliteit, Gynaecologie en Obstetrie

    An Reyners (Invited speaker)

    Activity: Participating in or organising an eventParticipation in conferenceProfessional

  3. 19th annual meeting

    An Reyners (Speaker)

    Activity: Talk or presentationProfessional

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Press / Media
  1. Moleculaire processen zichtbaar maken met PET

    Erik Vries, de


    1 Media contribution

    Press/Media: ResearchProfessional

  2. Covid2019: ACE2-receptor speelde ook grote rol bij SARS.

    Wim Timens & Martijn Nawijn


    1 Media contribution

    Press/Media: Public Engagement ActivitiesAcademic

  3. Revival van de Dutch Hypothesis, in geïndividualiseerde vorm.

    Wim Timens & Irene Heijink


    1 Media contribution

    Press/Media: Public Engagement ActivitiesAcademic

View all (135) »

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