Cancer Research Center Groningen (CRCG)
University of Groningen > Faculty of Medical Sciences > Cancer Research Center Groningen (CRCG)
Contact information
- Phone: +31 50 363 4734
- E-mail: crcg@umcg.nl
Organisational unit profile
Fundamental, Clinical and Translational Cancer Research.
The Cancer Research Center Groningen (CRCG) was established in 2012. The aim is to translate fundamental insights in oncogenesis and tumour behaviour from basic research into cancer prevention, improvement of early detection of cancer, and better treatment for cancer patients.
The mission of the CRCG is to clarify the molecular mechanisms that determine malignant transformation in a broad spectrum of tumors and to translate these fundamental insights into improved early detection and treatment of cancers. This will ultimately lead to personalized cancer therapy, thus reducing the unintended side effects of treatment on normal tissues and improving the quality of life of cancer survivors.
The CRCG was founded in 2012 as an independent research institute of the University Medical Center Groningen. Four key research programmes have been established:
- Damage and Repair in Cancer Development and Cancer Treatment (DARE);
- Guided Treatment in optimal Selected cancer patientsTranslational and Clinical research in Oncology (GUTS);
- Stem cells, Aging, Leukemia and Lymphoma (SALL);
- TARgeted Gynaecologic Oncology (TARGON).
These programmes are supported by 60 PIs and 139 PhD or MD/PhD students who participate in the UMCG’s Graduate School of Medical Sciences (GSMS). The various programs are characterized by a strong interaction between basic and translational research programs, as shown by joint research meetings and projects.
Publications
CD47 expression defines efficacy of rituximab with CHOP in Non-Germinal Center B-cell (non-GCB) Diffuse Large B-Cell Lymphoma patients (DLBCL), but not in GCB DLBCL
Bouwstra, R., He, Y., de Boer, J. W., Kooistra, H., Cendrowicz, E., Fehrmann, R. S. N., Ammatuna, E., Eulenburg, C., Nijland, M., Huls, G., Bremer, E. & van Meerten, T., 13-Aug-2019, In : Cancer immunology research.Research output: Contribution to journal › Article › Academic › peer-review
Well-differentiated Neuroendocrine Carcinoma of the Larynx: Confusion of Terminology and Uncertainty of Early Studies
Hunt, J. L., Barnes, L., Triantafyllou, A., Gnepp, D. R., Devaney, K. O., Stenman, G., Halmos, G. B., Bishop, J. A., Skalova, A., Willems, S. M., Hellquist, H., Rinaldo, A. & Ferlito, A., Jul-2019, In : Advances in anatomic pathology. 26, 4, p. 246-250 5 p.Research output: Contribution to journal › Review article › Academic › peer-review
Clinical outcomes after surgery for primary aldosteronism: Evaluation of the PASO-investigators' consensus criteria within a worldwide cohort of patients
Int CoNNsortium Study Grp, Vorselaars, W. M. C. M., van Beek, D-J., Postma, E. L., Spiering, W., Rinkes, I. H. M. B., Valk, G. D. & Vriens, M. R., Jul-2019, In : Surgery. 166, 1, p. 61-68 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Inter-observer variability in target delineation increases during adaptive treatment of head-and-neck and lung cancer
Apolle, R., Appold, S., Bijl, H. P., Blanchard, P., Bussink, J., Faivre-Finn, C., Khalifa, J., Laprie, A., Lievens, Y., Madani, I., Ruffier, A., de Ruysscher, D., van Elmpt, W. & Troost, E. G. C., 26-Jun-2019, In : ACTA ONCOLOGICA. 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Stratification and prediction of remission in first-episode psychosis patients: the OPTiMiSE cohort study (vol 9, 20, 2019)
OPTIMISE Study Grp, Martinuzzi, E., Barbosa, S., Daoudlarian, D., Ali, W. B. H., Gilet, C., Fillatre, L., Khalfallah, O., Troudet, R., Jamain, S., Fond, G., Sommer, I., Leucht, S., Dazzan, P., McGuire, P., Arango, C., Diaz-Caneja, C. M., Fleischhacker, W., Rujescu, D., Glenthoj, B., Winter, I., Kahn, R. S., Yolken, R., Lewis, S., Drake, R., Davidovic, L., Leboyer, M. & Glaichenhaus, N., 21-Jun-2019, In : Translational Psychiatry. 9, 1 p., 171.Research output: Contribution to journal › Article › Academic › peer-review
Datasets
Replication data to: Cortisol and α-amylase secretion patterns between and within depressed and non-depressed individuals.
Booij, S. (Creator), Bos, E. (Creator), Bouwmans, M. (Creator), Kema, I. (Creator), University of Groningen, 6-Jul-2015
DOI: https://doi.org/10411/C8LWAC, https://doi.org/10.1371/journal.pone.0131002.s013
Dataset
Dataset: Total Body Metabolic Tumor Response in ALK Positive Non-Small Cell Lung Cancer Patients Treated with ALK Inhibition
Kerner, G. (Creator), Koole, M. J. B. (Creator), Bongaerts, A. H. H. (Creator), Pruim, J. (Creator), Groen, H. (Creator), University of Groningen, 23-Apr-2016
DOI: https://doi.org/10.6084/m9.figshare.3189766.v1
Dataset
Data: Direct chromosome-length haplotyping by single-cell sequencing
Lansdorp, P. (Creator), Sanders, A. D. (Creator), van Wietmarschen, N. (Creator), Falconer, E. (Creator), Hills, M. (Creator), Spierings, D. (Creator), Bevova, M. (Creator), Guryev, V. (Creator), University of Groningen, 26-Nov-2016
DOI: https://doi.org/10.5281/zenodo.599901
Dataset
Prizes
Best paper of the year at annual Dutch Hematology Congress 2019
Jan Jacob Schuringa (Recipient), 2019
Prize › Academic
European Laryngological Society Silver Fellowship
Gyorgy Halmos (Recipient), 2013
Prize: Fellowship awarded competitively › Academic
Personal fellowship of the Dutch Cancer Society to study Palliative Medicine
An Reyners (Recipient), 2005
Prize: Fellowship awarded competitively › Academic
Activities
Informatiemiddag voor hoofd-hals oncologie patiënten
Gyorgy Halmos (Invited speaker)28-May-2019Activity: Participating in or organising an event › Organising an event › Popular
Treatment of the eldery head and neck cancer patients
Gyorgy Halmos (Speaker)29-Jun-2019 → 3-Jul-2019Activity: Talk or presentation › Academic
Epigenetic Editing: reprogramming nuclear and mitochondrial gene expression
Marianne Rots (Speaker)20-Jun-2019Activity: Talk or presentation › Academic
Press / Media
Kankercellen onder de loep
Wim Timens & Bert Vegt, van der
16/04/2019
1 item of media coverage
Press/Media: Public Engagement Activities › Popular
Interview Hematon
04/04/2019
1 item of media coverage
Press/Media: Public Engagement Activities › Professional
PD-L1 kleuring vereist bij eerstelijnsbehandeling urotheelcarcinoom met pembrolizumab
01/04/2019
1 item of media coverage
Press/Media: Expert Comment › Professional
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