Striatal structure and its association with N-Acetylaspartate and glutamate in autism spectrum disorder and obsessive compulsive disorderNaaijen, J., Zwiers, M. P., Forde, N. J., Williams, S. C. R., Durston, S., Brandeis, D., Glennon, J. C., Franke, B., Lythgoe, D. J., Buitelaar, J. K. & TACTICS Consortium, Jan-2018, In : European Neuropsychopharmacology. 28, 1, p. 118-129 12 p.
Research output: Contribution to journal › Article › Academic › peer-review
Autism spectrum disorders (ASD) and obsessive compulsive disorder (OCD) are often comorbid and are associated with changes in striatal volumes and N-Acetylaspartate (NM) and glutamate levels. Here, we investigated the relation between dorsal striatal volume and NAA and glutamate levels. We additionally compared striatal volume and shape between ASD, OCD and controls. T1-weighted magnetic resonance (MR) images, proton spectra (1H-MRS) in the left striatum, and phenotypic information were collected from 54 children with ASD, 32 with OCD, and 56 controls (aged 8-13 years) in a four-site study. Dorsal striatal volume and shape were determined using the FMRIB integrated registration and segmentation tool (FIRST). Spectra were processed with Linear Combination Model. The relationship of left striatal volume with NAA and glutamate was investigated, and group comparisons were performed for NAA levels and for bilateral striatal volume and shape. NM levels were lower in subjects with ASD compared with controls (t=2.86, p= 0.005) and were associated with striatal volume 03=0.37, t=2.78, p=0.008). Glutamate levels were also associated with volume in the ASD group 03=0.38, t=2.46, p=0.018). No group differences were found for striatal volume or shape, but a post-hoc diagnosis-by-hemisphere interaction (F(2,129)=3.86, p=0.024) revealed greater asymmetry (right> left) in striatal volume for the disorder-groups compared with controls. Our findings show involvement of NM and glutamate in striatal volume in ASD and suggest greater asymmetry in paediatric ASD and OCD compared with controls, pointing to overlapping subcortical abnormalities. The lower NAA in ASD reflects reduced neuronal integrity or impaired neuronal functioning. (C) 2017 Elsevier B.V. All rights reserved.
|Number of pages||12|
|Publication status||Published - Jan-2018|
- OCD, ASD, Glutamate, N-Acetylaspartate, Striatum, Structure, PERVASIVE DEVELOPMENTAL DISORDERS, DIAGNOSTIC INTERVIEW, REPETITIVE BEHAVIORS, CAUDATE-NUCLEUS, SHAPE DEFORMITY, CORPUS STRIATUM, CHILDREN, VOLUME, PSYCHOPATHOLOGY, SCHIZOPHRENIA