Publication
Rhythm & Blues: Chronobiology in the pathophysiology and treatment of mood disorders
Knapen, S. E., 2019, [Groningen]: Rijksuniversiteit Groningen. 167 p.Research output: Thesis › Thesis fully internal (DIV)

Documents
- Title and contents
Final publisher's version, 218 KB, PDF document
- Chapter 1
Final publisher's version, 138 KB, PDF document
- Chapter 2
Final publisher's version, 290 KB, PDF document
- Chapter 3
Final publisher's version, 377 KB, PDF document
- Chapter 4
Final publisher's version, 99.7 KB, PDF document
- Chapter 5
Final publisher's version, 259 KB, PDF document
- Chapter 6
Final publisher's version, 414 KB, PDF document
- Chapter 7
Final publisher's version, 3.55 MB, PDF document
- Chapter 8
Final publisher's version, 572 KB, PDF document
- Chapter 9
Final publisher's version, 202 KB, PDF document
- Chapter 10
Final publisher's version, 180 KB, PDF document
- Chapter 11
Final publisher's version, 175 KB, PDF document
- Chapter 12
Final publisher's version, 163 KB, PDF document
- Complete thesis
Final publisher's version, 5.35 MB, PDF document
- Propositions
Final publisher's version, 42.9 KB, PDF document
The second part studied the direct relationship in rest-activity rhythms and bipolar disorder. We found patients with bipolar disorder are able to maintain a normal rest-activity rhythm outside a mood episode. Furthermore, we showed that sleep disturbances might function as a warning sign for an imminent mood episode. In a detailed study we found that especially in a manic episode sleep disturbances precede the mood episode. Lastly we studied a novel biomarker in activity patterns, which might be able to help diagnose bipolar disorder.
In the third part we showed patients with seasonal affective disorder can be successfully treated with light therapy in the morning. Only one week of light therapy might be enough and there is no need for individual timing of the light on what chronotype the patient is.
Original language | English |
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Qualification | Doctor of Philosophy |
Awarding Institution | |
Supervisors/Advisors |
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Award date | 17-Apr-2019 |
Place of Publication | [Groningen] |
Publisher | |
Print ISBNs | 978-94-034-1536-9 |
Electronic ISBNs | 978-94-034-1537-6 |
Publication status | Published - 2019 |
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