Neuroendocrine carcinoma of the head and neck: In search for a better outcome

van der Laan, T. P., 2017, [Groningen]: Rijksuniversiteit Groningen. 152 p.

Research output: ThesisThesis fully internal (DIV)Academic

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Neuroendocrine carcinoma of the head and neck (NCHN) form a rare subgroup of head and neck cancer with clinical characteristics different from squamous cell carcinoma (SCC). NCHN most commonly involve the larynx and sinonasal tract. They can be subdivided based on differentiation grade into well, moderately and poorly differentiated neuroendocrine carcinoma. Additionally, the latter consists of a small and intermediate to large cell variant. Due to their rare nature and resulting lack of treatment guidelines, they are often approached using treatment protocols developed for SCC of the head and neck (SCCHN). This yields suboptimal treatment results as there are important differences in response to therapy between NCHN and SCCHN. In this thesis we elucidate these differences, and provide treatment guidelines for each subtype, by reviewing our institutional experience and by combining all available data in the literature. Furthermore, we evaluate human papilloma virus infection as a possible prognostic marker in neuroendocrine carcinoma of the larynx.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Award date29-Nov-2017
Place of Publication[Groningen]
Print ISBNs978-94-6332-270-6
Publication statusPublished - 2017

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