Between adaptation and virulence: A proteomics view on Staphylococcus aureus infections

Palma Medina, L. M., 2019, [Groningen]: University of Groningen. 234 p.

Research output: ThesisThesis fully internal (DIV)

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  • Title and contents

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  • Chapter 1

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  • Chapter 2

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  • Chapter 3

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  • Chapter 4

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  • Chapter 5

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  • Chapter 6

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  • Chapter 7

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  • Appendices

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  • Complete thesis

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  • Propositions

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Staphylococcus aureus is a regular resident of the human body. This bacterium is carried by around 30% of the healthy population, most frequently in the nasal cavity. Although carriage of S. aureus is generally asymptomatic, it is a renowned pathogen capable of causing diseases that range from mild skin infections to necrotizing pneumonia. Such infections may be difficult to treat, not only because this bacterium rapidly develops resistance to antibiotics, but also because it can effectively adapt to different environments within and around the human body. The adaptive mechanisms of S. aureus have been studied for many years in well-controlled laboratory settings. This has deepened our understanding of bacterial adaptations. Yet, the challenges imposed on the bacterium during infection of human cells and tissues are more complex, and the respective bacterial responses are still poorly understood especially since the bacterium needs to activate and modulate several adaptive pathways simultaneously. In the present PhD research, new technologies allowing precise quantification of proteins have been employed to assess the adaptive behavior of S. aureus, firstly upon invasion of lung epithelial cells, but also in response to different epidemiological conditions in the hospital and the general population. Importantly, the changes in protein abundance reflect the “decisions” taken by the pathogen in these widely differing conditions. The results presented in this thesis highlight the importance of adaptations in bacterial metabolism during infection, and they show that metabolic adaptations play critical roles in the outcome of infections caused by S. aureus.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Award date8-Jul-2019
Place of Publication[Groningen]
Print ISBNs978-94-034-1824-7
Electronic ISBNs978-94-034-1823-0
Publication statusPublished - 2019

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