Wibowo, J. P., Xiao, Z., Voet, J. M., Dekker, F. J., & Quax, W. J. (2020). Development of phenylthiourea derivatives as allosteric inhibitors of pyoverdine maturation enzyme PvdP tyrosinase. Bioorganic & Medicinal Chemistry Letters, 30(17), [127409]. https://doi.org/10.1016/j.bmcl.2020.127409

Hartman, A. M., Elgaher, W. A. M., Hertrich, N., Andrei, S. A., Ottmann, C., & Hirsch, A. K. H. (2020). Discovery of Small-Molecule Stabilizers of 14-3-3 Protein-Protein Interactions via Dynamic Combinatorial Chemistry. Bioorganic & Medicinal Chemistry Letters, 11(5), 1041-1046. https://doi.org/10.1021/acsmedchemlett.9b00541

Geersing, A., de Vries, R. H., Jansen, G., Rots, M. G., & Roelfes, G. (2019). Folic acid conjugates of a bleomycin mimic for selective targeting of folate receptor positive cancer cells. Bioorganic & Medicinal Chemistry Letters, 29(15), 1922-1927. https://doi.org/10.1016/j.bmcl.2019.05.047

Della Volpe, S., Nasti, R., Queirolo, M., Unver, M. Y., Jumde, V. K., Dömling, A., Vasile, F., Potenza, D., Ambrosio, F. A., Costa, G., Alcaro, S., Zucal, C., Provenzani, A., Di Giacomo, M., Rossi, D., Hirsch, A. K. H., & Collina, S. (2019). Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies. Bioorganic & Medicinal Chemistry Letters, 10(4), 615-620. https://doi.org/10.1021/acsmedchemlett.8b00600

Zarganes-Tzitzikas, T., Neochoritis, C. G., & Dömling, A. (2019). Atorvastatin (Lipitor) by MCR. Bioorganic & Medicinal Chemistry Letters, 10(3), 389-392. https://doi.org/10.1021/acsmedchemlett.8b00579

Estrada-Ortiz, N., Neochoritis, C. G., Twarda-Clapa, A., Musielak, B., Holak, T. A., & Dömling, A. (2017). Artificial Macrocycles as Potent p53-MDM2 Inhibitors. Bioorganic & Medicinal Chemistry Letters, 8(10), 1025-1030. https://doi.org/10.1021/acsmedchemlett.7b00219

Neochoritis, C. G., Wang, K., Estrada-Ortiz, N., Herdtweck, E., Kubica, K., Twarda, A., Zak, K. M., Holak, T. A., & Dömling, A. (2015). 2,30-Bis(10H-indole) heterocycles: New p53/MDM2/MDMX antagonists. Bioorganic and Medicinal Chemistry Letters, 25(24), 5661-5666. https://doi.org/10.1016/j.bmcl.2015.11.019

Seerden, J-P. G., Leusink-Ionescu, G., Woudenberg - Vrenken, T., Dros, B., Molema, G., Kamps, J. A. A. M., & Kellogg, R. M. (2014). Synthesis and structure-activity relationships of 4-fluorophenyl-imidazole p38 alpha MAPK, CK1 delta and JAK2 kinase inhibitors. Bioorganic & Medicinal Chemistry Letters, 24(15), 3412-3418. https://doi.org/10.1016/j.bmcl.2014.05.080

Seerden, J-P. G., Leusink-Ionescu, G., Leguijt, R., Saccavini, C., Gelens, E., Dros, B., Woudenberg-Vrenken, T., Molema, G., Kamps, J. A. A. M., & Kellogg, R. M. (2014). Syntheses and structure-activity relationships for some triazolyl p38 alpha MAPK inhibitors. Bioorganic & Medicinal Chemistry Letters, 24(5), 1352-1357. https://doi.org/10.1016/j.bmcl.2014.01.034

Messori, L., Casini, A., Gabbiani, C., Michelucci, E., Cubo, L., Rios-Luci, C., Padron, J. M., Navarro-Ranninger, C., & Quiroga, A. G. (2010). Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel "Rule-Breaker" Iodidoplatinum(II) Complex. Bioorganic & Medicinal Chemistry Letters, 1(8), 381-385. https://doi.org/10.1021/ml100081e

Cinellu, M. A., Maiore, L., Manassero, M., Casini, A., Arca, M., Fiebig, H-H., Kelter, G., Michelucci, E., Pieraccini, G., Gabbiani, C., & Messori, L. (2010). [Au-2(phen(2Me))(2)(mu-O)(2)](PF6)(2), a Novel Dinuclear Gold(III) Complex Showing Excellent Antiproliferative Properties. Bioorganic & Medicinal Chemistry Letters, 1(7), 336-339. https://doi.org/10.1021/ml100097f

Pingali, H., Jain, M., Shah, S., Zaware, P., Makadia, P., Pola, S., Thube, B., Patel, D., Patil, P., Priyadarshini, P., Suthar, D., Shah, M., Giri, S., & Patel, P. (2010). Design and synthesis of novel bis-oximinoalkanoic acids as potent PPARα agonists. Bioorganic & Medicinal Chemistry Letters, 20(3), 1156-1161. https://doi.org/10.1016/j.bmcl.2009.12.022

Haney, C. M., Schneider, C., Beck, B., Brodsky, J. L., & Doemling, A. (2009). Identification of Hsp70 modulators through modeling of the substrate binding domain. Bioorganic & Medicinal Chemistry Letters, 19(14), 3828-3831. https://doi.org/10.1016/j.bmcl.2009.04.062

Pingali, H., Jain, M., Shah, S., Patil, P., Makadia, P., Zaware, P., Sairam, K. V. V. M., Jamili, J., Goel, A., Patel, M., & Patel, P. (2008). Modulation of PPAR receptor subtype selectivity of the ligands: Aliphatic chain vs aromatic ring as a spacer between pharmacophore and the lipophilic moiety. Bioorganic & Medicinal Chemistry Letters, 18(24), 6471-6475. https://doi.org/10.1016/j.bmcl.2008.10.062

Pingali, H., Jain, M., Shah, S., Basu, S., Makadia, P., Goswami, A., Zaware, P., Patil, P., Godha, A., Giri, S., Goel, A., Patel, M., Patel, H., & Patel, P. (2008). Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent. Bioorganic & Medicinal Chemistry Letters, 18(20), 5586-5590. https://doi.org/10.1016/j.bmcl.2008.08.112

Doemling, A., Antuch, W., Beck, B., & Schauer-Vukasinovic, V. (2008). Isosteric exchange of the acylsulfonamide moiety in Abbott's Bcl-X(L) protein interaction antagonist. Bioorganic & Medicinal Chemistry Letters, 18(14), 4115-4117. https://doi.org/10.1016/j.bmcl.2008.05.096

Doemling, A., Achatz, S., & Beck, B. (2007). Novel anti-tuberculosis agents from MCR libraries. Bioorganic & Medicinal Chemistry Letters, 17(19), 5483-5486. https://doi.org/10.1016/j.bmcl.2007.04.066

Doemling, A., Beck, B., Baumbach, W., & Larbig, G. (2007). Towards erythropoietin mimicking small molecules. Bioorganic & Medicinal Chemistry Letters, 17(2), 379-384. https://doi.org/10.1016/j.bmcl.2006.10.040

Sexton, K. B., Witte, M. D., Blum, G., & Bogyo, M. (2007). Design of cell-permeable, fluorescent activity-based probes for the lysosomal cysteine protease asparaginyl endopeptidase (AEP)/legumain. Bioorganic & Medicinal Chemistry Letters, 17(3), 649-653. https://doi.org/10.1016/j.bmcl.2006.10.100

Achatz, S., & Dömling, A. (2006). Desosamine in multicomponent reactions. Bioorganic and Medicinal Chemistry Letters, 16(24), 6360-6362. https://doi.org/10.1016/j.bmcl.2006.07.017

Antuch, W., Menon, S., Chen, Q-Z., Lu, Y., Sakamuri, S., Beck, B., Schauer-Vukašinović, V., Agarwal, S., Hess, S., & Dömling, A. (2006). Design and modular parallel synthesis of a MCR derived α-helix mimetic protein-protein interaction inhibitor scaffold. Bioorganic and Medicinal Chemistry Letters, 16(6), 1740-1743. https://doi.org/10.1016/j.bmcl.2005.11.102

Mincione, F., Starnotti, M., Masini, E., Bacciottini, L., Scrivanti, C., Casini, A., Vullo, D., Scozzafava, A., & Supuran, CT. (2005). Carbonic anhydrase inhibitors: Design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma. Bioorganic & Medicinal Chemistry Letters, 15(17), 3821-3827. https://doi.org/10.1016/j.bmcl.2005.06.054

De Simone, G., Di Fiore, A., Menchise, N. V., Pedone, C., Antel, J., Casini, A., Scozzafava, A., Wurl, M., & Supuran, CT. (2005). Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies. Bioorganic & Medicinal Chemistry Letters, 15(9), 2315-2320. https://doi.org/10.1016/j.bmcl.2005.03.032

Di Fiore, A., De Simone, G., Menchise, N. V., Pedone, C., Casini, A., Scozzafava, A., & Supuran, CT. (2005). Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II. Bioorganic & Medicinal Chemistry Letters, 15(7), 1937-1942. https://doi.org/10.1016/j.bmcl.2005.01.086

Zimmerman, S., Innocenti, A., Casini, A., Ferry, JG., Scozzafava, A., & Supuran, CT. (2004). Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides. Bioorganic & Medicinal Chemistry Letters, 14(24), 6001-6006. https://doi.org/10.1016/j.bmcl.2004.09.085

Lehtonen, J. M., Parkkila, S., Vullo, D., Casini, A., Scozzafava, A., & Supuran, C. T. (2004). Carbonic anhydrase inhibitors: Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: A novel target for the drug design. Bioorganic & Medicinal Chemistry Letters, 14(14), 3757-3762. https://doi.org/10.1016/j.bmcl.2004.04.106

Yehia, N. A. M., Antuch, W., Beck, B., Hess, S., Schauer-Vukašinović, V., Almstetter, M., Furer, P., Herdtweck, E., & Dömling, A. (2004). Novel nonpeptidic inhibitors of HIV-1 protease obtained via a new multicomponent chemistry strategy. Bioorganic and Medicinal Chemistry Letters, 14(12), 3121-3125. https://doi.org/10.1016/j.bmcl.2004.04.026

Pastorekova, S., Casini, A., Scozzafava, A., Vullo, D., Pastorek, J., & Supuran, C. T. (2004). Carbonic anhydrase inhibitors: The first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX. Bioorganic & Medicinal Chemistry Letters, 14(4), 869-873. https://doi.org/10.1016/j.bmcl.2003.12.029

Abbate, F., Coetzee, A., Casini, A., Ciattini, S., Scozzafava, A., & Supuran, CT. (2004). Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride. Bioorganic & Medicinal Chemistry Letters, 14(2), 337-341. https://doi.org/10.1016/j.bmcl.2003.11.014

Winum, JY., Casini, A., Mincione, F., Starnotti, M., Montero, JL., Scozzafava, A., & Supuran, CT. (2004). Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits. Bioorganic & Medicinal Chemistry Letters, 14(1), 225-229. https://doi.org/10.1016/j.bmcl.203.09.063

Abbate, F., Winum, JY., Potter, BVL., Casini, A., Montero, JL., Scozzafava, A., & Supuran, CT. (2004). Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase. Bioorganic & Medicinal Chemistry Letters, 14(1), 231-234. https://doi.org/10.1016/j.bmcl.2003.09.064

Abbate, F., Casini, A., Owa, T., Scozzafava, A., & Supuran, CT. (2004). Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorganic & Medicinal Chemistry Letters, 14(1), 217-223. https://doi.org/10.1016/j.bmcl.2003.09.062

Abbate, F., Casini, A., Scozzafava, A., & Supuran, C. T. (2004). Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a topically acting antiglaucoma sulfonamide. Bioorganic & Medicinal Chemistry Letters, 14(9), 2357 - 2361. https://doi.org/10.1016/j.bmcl.2004.01.096

Casini, A., Scozzafava, A., Mincione, F., Menabuoni, L., Starnotti, M., & Supuran, CT. (2003). Carbonic anhydrase inhibitors: Topically acting antiglaucoma sulfonamides incorporating esters and amides of 3-and 4-carboxybenzolamide. Bioorganic & Medicinal Chemistry Letters, 13(17), 2867-2873. https://doi.org/10.1016/S0960-894X(03)00580-8

Casini, A., Caccia, S., Scozzafava, A., & Supuran, CT. (2003). Carbonic anhydrase activators. The selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram are strong activators of Isozymes I and II. Bioorganic & Medicinal Chemistry Letters, 13(16), 2765-2768. https://doi.org/10.1016/S0960-894X(03)00507-9

Casini, A., Abbate, F., Scozzafava, A., & Supuran, CT. (2003). Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a bis-sulfonamide - Two heads are better than one? Bioorganic & Medicinal Chemistry Letters, 13(16), 2759-2763. https://doi.org/10.1016/S0960-894X(03)00508-0

Dekker, F. J., de Mol, N. J., Fischer, M. J. E., Liskamp, R. M. J., & Dekker, F. (2003). Amino propynyl benzoic acid building block in rigid spacers of divalent ligands binding to the Syk SH2 domains with equally high affinity as the natural ligand. Bioorganic & Medicinal Chemistry Letters, 13(7), 1241-4.

Casini, A., Antel, J., Abbate, F., Scozzafava, A., David, S., Waldeck, H., Schafer, S., & Supuran, CT. (2003). Carbonic anhydrase inhibitors: SAR and x-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with Isozymes I, II and IV. Bioorganic & Medicinal Chemistry Letters, 13(5), 841-845. https://doi.org/10.1016/S0960-894X(03)00029-5

Casini, A., Winum, JY., Montero, JL., Scozzafava, A., & Supuran, CT. (2003). Carbonic anhydrase inhibitors: Inhibition of cytosolic isozymes I and II with sulfamide derivatives. Bioorganic & Medicinal Chemistry Letters, 13(5), 837-840. https://doi.org/10.1016/S0960-894X(03)00028-3

Mincione, F., Starnotti, M., Menabuoni, L., Scozzafava, A., Casini, A., & Supuran, CT. (2001). Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties. Bioorganic & Medicinal Chemistry Letters, 11(13), 1787-1791. https://doi.org/10.1016/S0960-894X(01)00303-1

Beck, B., Hess, S., & Dömling, A. (2000). One-pot synthesis and biological evaluation of aspergillamides and analogues. Bioorganic and Medicinal Chemistry Letters, 10(15), 1701-1705. https://doi.org/10.1016/S0960-894X(00)00305-X

Dömling, A., Chi, K-Z., & Barrère, M. (1999). A novel method to highly versatile monomeric PNA building blocks by multi component reactions. Bioorganic and Medicinal Chemistry Letters, 9(19), 2871-2874. https://doi.org/10.1016/S0960-894X(99)00491-6

Pieters, R. J., Fennema, M., Kellogg, R. M., & Janssen, D. B. (1999). Design and Synthesis of Reagents for Phage Display Screening of Dehalogenases. Bioorganic & Medicinal Chemistry Letters, 9(2), 161-166. https://doi.org/10.1016/S0960-894X(98)00697-0

Liao, Y., Kozikowski, AP., Guidotti, A., & Costa, E. (1998). Synthesis and pharmacological evaluation of benzofuran-acetamides as "antineophobic" mitochondrial DBI receptor complex ligands. Bioorganic & Medicinal Chemistry Letters, 8(16), 2099 - 2102. https://doi.org/10.1016/s0960-894x(98)00374-6

Nasir, AI., Gundersen, LL., Rise, F., Antonsen, O., Kristensen, T., Langhelle, B., Bast, A., Custers, N. V., Haenen, GRMM., & Wikstrom, H. (1998). Inhibition of lipid peroxidation mediated by indolizines. Bioorganic & Medicinal Chemistry Letters, 8(14), 1829-1832.

Kozikowski, AP., Liao, Y., Tuckmantel, W., Wang, SM., Pshenichkin, S., Surin, A., Thomsen, C., & Wroblewski, JT. (1996). Synthesis and biology of the rigidified glutamate analogue, trans-2-carboxyazetidine-3-acetic acid (t-CAA). Bioorganic & Medicinal Chemistry Letters, 6(21), 2559-2564.

Leenders, RGG., Scheeren, HW., Houba, PHJ., Boven, E., & Haisma, HJ. (1995). Synthesis and evaluation of novel daunomycin-phosphate -sulfate -beta-glucuronide and -beta-glucoside prodrugs for application in ADEPT. Bioorganic & Medicinal Chemistry Letters, 5(24), 2975-2980.

Pombo-Villar, E., Supavilai, P., Weber, H. P., & Boddeke, H. W. G. M. (1992). 6-carboxymethyl-2-azabicyclo[2.2.1]heptane enantiomers: Muscarinic activities of rigid analogues of arecoline. Bioorganic and Medicinal Chemistry Letters, 2(5), 501-504. https://doi.org/10.1016/S0960-894X(00)80178-X

SHAPIRO, G., FLOERSHEIM, P., AMSTUTZ, R., BODDEKE, H., BOLLIGER, G., COTTENS, S., ENZ, A., GMELIN, G., GULL, P., & SUPAVILAI, P. (1992). MUSCARINIC AGONIST SAR OF AZASPIRODIOXOLANES. Bioorganic & Medicinal Chemistry Letters, 2(8), 815-820.

POMBOVILLAR, E., SUPAVILAI, P., WEBER, HP., & BODDEKE, HWGM. (1992). 6-CARBOXYMETHYL-2-AZABICYCLO[2.2.1]HEPTANE ENANTIOMERS - MUSCARINIC ACTIVITIES OF RIGID ANALOGS OF ARECOLINE. Bioorganic & Medicinal Chemistry Letters, 2(5), 501-504.