Publication

The first 1000 days and beyond: From early life environment to epigenetics and childhood overweight

Küpers, L. K. 2016 [Groningen]: Rijksuniversiteit Groningen. 367 p.

Research output: ScientificThesis fully internal (DIV)

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  • Title and contents

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  • Chapter 1

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  • Chapter 2

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  • Chapter 3

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  • Chapter 4

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    Embargo ends: 18/05/2018

  • Chapter 5

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  • Chapter 6

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  • Chapter 7

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  • Chapter 8

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  • Chapter 9

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  • Chapter 10

    Final publisher's version, 191 KB, PDF-document

  • Chapter 11

    Final publisher's version, 497 KB, PDF-document

  • Complete thesis

    Final publisher's version, 5 MB, PDF-document

    Embargo ends: 18/05/2018

  • Propositions

    Final publisher's version, 533 KB, PDF-document

The first 1000 days of life (from conception to two years of age) are highlighted in this thesis as a crucial period for the prevention of overweight.

This PhD thesis showed that a healthy respectively unhealthy lifestyle of mothers during pregnancy could change the DNA methylation of their children (measured in umbilical cord blood). An important lifestyle factor during pregnancy that changed DNA methylation was maternal smoking; studies in this thesis showed that hundreds of genes of newborns could be influenced by smoking of the mother. New-born babies of smoking mothers weighed on average 200 grams less than the babies of non-smoking mothers. Nearly 20 percent of this lower birth weight could be accounted for by the change in DNA methylation in one gene that we studied. Our expectation is that, through DNA methylation, a child can be programmed during pregnancy as susceptible or resilient to the unhealthy “obesogenic” environment later in life.

In this thesis we showed that growth in the first years of life played an important role in the development of overweight. Growth in the first six months was highly dependent on birth weight and breastfeeding. Additionally, we showed that dietary habits (fruit, vegetables, sweetened beverages and snacks) in toddlers were already related to deviation from the normal growth curve. Skipping breakfast was not yet a problem in Dutch five year old children. This behaviour will probably start to play a role at a later age.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Supervisors/Advisors
Award date18-May-2016
Place of Publication[Groningen]
Publisher
Print ISBNs978-94-6299-336-5
StatePublished - 2016

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