Publication
Shaping the future of paediatric pulmonary arterial hypertension
Douwes, J. M. 2017 [Groningen]: Rijksuniversiteit Groningen. 295 p.Research output: Scientific › Thesis fully internal (DIV)

Documents
- Title and contents
Final publisher's version, 2 MB, PDF-document
- Chapter 01
Final publisher's version, 3 MB, PDF-document
- Chapter 02
Final publisher's version, 4 MB, PDF-document
- Chapter 03a
Final publisher's version, 3 MB, PDF-document
- Chapter 03b
Final publisher's version, 3 MB, PDF-document
- Chapter 04
Final publisher's version, 3 MB, PDF-document
- Chapter 05
Final publisher's version, 3 MB, PDF-document
- Chapter 06
Final publisher's version, 3 MB, PDF-document
- Chapter 07
Final publisher's version, 3 MB, PDF-document
- Chapter 08
Final publisher's version, 3 MB, PDF-document
- Chapter 09
Final publisher's version, 3 MB, PDF-document
- Chapter 10
Final publisher's version, 3 MB, PDF-document
- Chapter 11
Final publisher's version, 3 MB, PDF-document
- Chapter 12
Final publisher's version, 4 MB, PDF-document
- Chapter 13
Final publisher's version, 3 MB, PDF-document
- Appendices
Final publisher's version, 4 MB, PDF-document
- Complete thesis
Final publisher's version, 12 MB, PDF-document
- Propositions
Final publisher's version, 627 KB, PDF-document
The epidemiologic data from this thesis provides new information on the presentation, associated diseases and risk factors of PAH. This data helps to detect the disease in an earlier phase and even screen for the disease in specific risk groups.
The current paediatric acute response criteria, used to identify children that qualify for calcium channel blocker therapy, could be rejected based on this thesis. We demonstrated that newer criteria could better identify patients that respond well to calcium channel blocker therapy. Hereby the right patients can be selected for calcium channel blocker therapy and PAH-targeted therapy is not wrongly withheld for false responders.
Furthermore, we provided the first evidence that add-on therapy is effective in children with PAH and that combination therapy improves outcome compared to mono-therapy. Also, we could identify parameters that can predict outcome of children with PAH and that can serve as treatment targets. Therefore this thesis provides a scientific basis for an aggressive treatment strategy for children with PAH, that can improve outcome for these children.
Original language | English |
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Qualification | Doctor of Philosophy |
Awarding Institution | |
Supervisors/Advisors |
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Award date | 18-Jan-2017 |
Place of Publication | [Groningen] |
Publisher | |
Print ISBNs | 978-94-6169-993-0 |
State | Published - 2017 |
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