Radiation-induced cardiopulmonary dysfunction: Pathophysiology & Intervention strategies

van der Veen, S. J. 2016 [Groningen]: Rijksuniversiteit Groningen. 154 p.

Research output: ThesisThesis fully internal (DIV)

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  • Title and contents

    Final publisher's version, 857 KB, PDF-document

  • Chapter 1

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  • Chapter 2

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  • Chapter 3

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  • Chapter 4

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  • Chapter 5

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  • Chapter 6

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  • Chapter 7

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  • Appendices

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  • Complete thesis

    Final publisher's version, 16 MB, PDF-document

  • Propositions

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  • Sjoerdtje Johanna van der Veen
Radiotherapy is an important treatment modality for thoracic tumours. Unfortunately, the radiation dose is restricted by the risk of normal-tissue toxicity of the surrounding healthy tissues such as the lung and heart.
In this thesis we aimed to get more insight into the pathophysiology of radiation-induced cardiopulmonary dysfunction (RICPD) to find new/better predictors of the development and possible attenuating intervention strategies of RICPD.
In our rat model, we found that besides inflammation pulmonary vascular damage and remodelling play a critical role in the development of early RICPD. In addition, damage in heart and lungs were found to secondarily damage the other and combined irradiation even enhances the toxicity. These findings may help improve biophysical models to predict RICPD. Moreover, our findings provide new insights how to diminish/repair RICPD, such as the observed ameliorating effect of the ACE inhibitor captopril directly on early heart toxicity and indirectly via its interaction with early lung toxicity. Moreover, preliminary results indicated that transplantation of endothelial progenitor cells may ameliorate RICPD by repairing vascular damage.
To conclude, translation of these preclinical findings to clinic may improve radiotherapy treatment and even provide tumour dose escalation leading to a better tumour control and increase survival of the patient.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Award date2-Nov-2016
Place of Publication[Groningen]
Print ISBNs978-90-367-9151-9
Electronic ISBNs978-90-367-9148-9
StatePublished - 2016

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