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Plasminogen activator inhibitor-1 and tissue plasminogen activator and incident AF: Data from the PREVEND study

Mulder, B. A., Geelhoed, B., van der Harst, P., Spronk, H. M., Van Gelder, I. C., Asselbergs, F. W. & Rienstra, M., 1-Dec-2018, In : International Journal of Cardiology. 272, p. 208-210 3 p.

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Background: Tissue-type plasminogen activator (TPA) and plasminogen activator inhibitor-1 (PAI-1) have been shown to be associated with increased risk for stroke, however, the association with incident atrial fibrillation (AF) is unknown.

Methods: We examined 8265 individuals included in the PREVEND study. In all subjects. PAI-1 and TPA plasma/serum levels were measured using an ELISA kit. By means of univariate and multivariate analyses the association with incident AF was assessed.

Results: Mean age was age 49 +/- 13 years, and 50% were women. Of the 8265 patients free of AF at baseline, 267 (3.2%) patients developed incident AF during a mean follow-up of 9.7 +/- 2.4 years. Baseline median levels of PAI-1 and TPA were 72.4 ng/ml and 3.1 ng/ml, respectively. In univariate analyses PM-i (Hazard ratio [HR] 1.10 95% Confidence interval [CI] 1.04-1.16, p <0.001) and TPA (HR 1.05, 95% CI 1.01-1.08, p = 0.014) were associated with incident AF. However, after multivariate adjustment for age, sex, antihypertensive drugs, stroke, heart failure, myocardial infarction, diabetes mellitus, peripheral arterial disease, smoking, NT-proBNP, alcohol consumption, body mass index no significant association was found.

Conclusion: In this community-based cohort. PAI-1 and TPA levels were not associated with incident AF. (C) 2018 The Authors. Published by Elsevier B.V.

Original languageEnglish
Pages (from-to)208-210
Number of pages3
JournalInternational Journal of Cardiology
Volume272
Publication statusPublished - 1-Dec-2018

    Keywords

  • PAI-1, TPA, Atrial fibrillation, ATRIAL-FIBRILLATION, CARDIOVASCULAR EVENTS, HEART-FAILURE, DYSFUNCTION, STROKE, STATE, EPIDEMIOLOGY, PREDICTOR, MORTALITY, MARKERS

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