Mortality and preoperative cardiac function in vascular amputees: an N-terminal pro-brain natriuretic peptide (NT-proBNP) pilot study

Riemersma, M., Dijkstra, P. U., van Veldhuisen, D. J., Muskiet, F. A. J., van den Dungen, J. A. M. M. & Geertzen, J. H. B., Jan-2008, In : Clinical Rehabilitation. 22, 1, p. 56-59 4 p.

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Objective: To determine preoperative ventricular function in vascular amputees by measuring N-terminal pro-brain natriuretic peptide (NT-proBNP) and to analyse the relationship between NT-proBNP levels and 30-day postoperative mortality.

Design: Prospective pilot study. Subjects and methods: In 19 patients planned for a lower limb amputation for nonreconstructable peripheral arterial disease NT-proBNP was measured the day before amputation.

Results: Four amputees died within 30 days after the amputation. In 17 of 19 patients NT-proBNP values were found more than 2 standard deviations above the age corrected reference value. Pre-amputation NT-proBNP levels did not differ significantly between non-survivors and survivors (P=0.162).

Conclusion: Preoperative NT-proBNP levels are not significantly related to 30-day mortality after lower limb amputation procedure. Preoperative NT-proBNP levels are very high, indicating that serious ventricular dysfunction may be present in vascular amputees.

Original languageEnglish
Pages (from-to)56-59
Number of pages4
JournalClinical Rehabilitation
Issue number1
Publication statusPublished - Jan-2008

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