Publication

Incidence rates of dysvascular lower extremity amputation changes in Northern Netherlands: A comparison of three cohorts of 1991-1992, 2003-2004 and 2012-2013

Fard, B., Dijkstra, P. U., Stewart, R. E. & Geertzen, J. H. B., 24-Sep-2018, In : PLoS ONE. 13, 9, 12 p., 0204623.

Research output: Contribution to journalArticleAcademicpeer-review

Objective

To analyze the incidence rates of dysvascular major lower extremity amputations (LEA) in Northern Netherlands in 2012-2013 compared to previous cohorts in 1991-1992 and 2003-2004.

Design

Retrospective cohort study.

Participants

Adults (N = 343) with first ever dysvascular LEA at ankle disarticulation or more proximal levels. The median age (interquartile range) was 74.2 years (64.5-81.9), 64% were male and 55% had been diagnosed with diabetes mellitus (DM).

Main outcome measures

Crude and age-standardized incidence rates of major LEA per 100.000 person-years.

Results

Crude incidence rate (IR) of first ever major LEA in 2012-2013 was 9.9 per 100.000 person-years, while the age-standardized IR was 7.7 per 100.000 person-years. A Poisson regression analysis showed that amputation rates among men were 2.3 times higher compared to women (95%CI 1.9-2.6), while in 2012-2013 the population aged >63 years had decreased amputation rates compared to 1991-1992. In the DM population the crude IR decreased from 142.6 per 100.000 person-years in 2003-2004 to 89.2 per 100.000 person-years in 2012-2013 (p

Conclusions

In 2012-2013 a decrease in age-standardized IR for the general population and a decrease in crude IR for the DM population were observed compared to cohorts from the previous two decades, despite considerable shifts in the age distribution of the Dutch population towards more elderly people and increased prevalence of DM. These findings might suggest that improved treatment of patients at risk of dysvascular amputations is associated with reduced incidence rates of major LEA at the population level.

Original languageEnglish
Article number0204623
Number of pages12
JournalPLoS ONE
Volume13
Issue number9
Publication statusPublished - 24-Sep-2018

    Keywords

  • LOWER-LIMB AMPUTATION, PERIPHERAL ARTERIAL-DISEASE, DIABETES-MELLITUS, REDUCED INCIDENCE, UNITED-STATES, HEALTH-CARE, FOOT CARE, TRENDS, PEOPLE, REVASCULARIZATION
Related Datasets
  1. Dataset: amputees and CBS data 5 years categories

    Fard, B. (Creator), Dijkstra, P. (Creator), Stewart, R. (Creator), Geertzen, J. (Creator), University of Groningen, 16-Aug-2018

    Dataset

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