Gut microbiota, metabolism and psychopathology: A critical review and novel perspectives

Groen, R. N., de Clercq, N. C., Nieuwdorp, M., Hoenders, H. J. R. & Groen, A. K. Jun-2018 In : Critical reviews in clinical laboratory sciences. 55, 4, p. 283-293 11 p.

Research output: Contribution to journalArticle

Psychiatric disorders are often associated with metabolic comorbidities. However, the mechanisms through which metabolic and psychiatric disorders are connected remain unclear. Pre-clinical studies in rodents indicate that the bidirectional signaling between the intestine and the brain, the so-called microbiome-gut-brain axis, plays an important role in the regulation of both metabolism and behavior. The gut microbiome produces a vast number of metabolites that may be transported into the host and play a part in homeostatic control of metabolism as well as brain function. In addition to short chain fatty acids, many of these metabolites have been identified in recent years. To what extent both microbiota and their products control human metabolism and behavior is a subject of intense investigation. In this review, we will discuss the most recent findings concerning alterations in the gut microbiota as a possible pathophysiological factor for the co-occurrence of metabolic comorbidities in psychiatric disorders.

Original languageEnglish
Pages (from-to)283-293
Number of pages11
JournalCritical reviews in clinical laboratory sciences
Issue number4
StatePublished - Jun-2018

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