Glucocorticosteroids Associated With a Decreased Risk of PsychosisLaan, W., Smeets, H., de Wit, N. J., Kahn, R. S., Grobbee, D. E. & Burger, H., Jun-2009, In : Journal of Clinical Psychopharmacology. 29, 3, p. 288-290 3 p.
Research output: Contribution to journal › Article › Academic › peer-review
The hypothesis that chronic inflammation may play a role in psychosis receives increasing attention. In this study, we aim to investigate whether the use of steroidal anti-inflammatory drugs is associated with a decreased risk of psychosis.
A longitudinal nested case-control study was performed investigating the association of glucocorticosteroid (GCS) consumption with a new diagnosis of a psychotic disorder. Significantly reduced odds ratios of 0.52 (95% confidence interval, 0.36-0.75) were found for GCS in men only (odds ratio in women, 0.84 [95% confidence interval, 0.590-1.20]). Similar risk reductions were present for the inhaled and systemic GCSs. A dose-response relationship was present. Our finding of an inverse relation between GCS consumption and new psychotic episodes may promote further research into inflammation in schizophrenia.
|Number of pages||3|
|Journal||Journal of Clinical Psychopharmacology|
|Publication status||Published - Jun-2009|
- schizophrenia, psychosis, inflammation, glucocorticosteroids, SCHIZOPHRENIA, CELECOXIB, THERAPY