Glucocorticosteroids Associated With a Decreased Risk of Psychosis

Laan, W., Smeets, H., de Wit, N. J., Kahn, R. S., Grobbee, D. E. & Burger, H., Jun-2009, In : Journal of Clinical Psychopharmacology. 29, 3, p. 288-290 3 p.

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  • Wijnand Laan
  • Hugo Smeets
  • Niek J. de Wit
  • Rene S. Kahn
  • Diederick E. Grobbee
  • Huibert Burger

The hypothesis that chronic inflammation may play a role in psychosis receives increasing attention. In this study, we aim to investigate whether the use of steroidal anti-inflammatory drugs is associated with a decreased risk of psychosis.

A longitudinal nested case-control study was performed investigating the association of glucocorticosteroid (GCS) consumption with a new diagnosis of a psychotic disorder. Significantly reduced odds ratios of 0.52 (95% confidence interval, 0.36-0.75) were found for GCS in men only (odds ratio in women, 0.84 [95% confidence interval, 0.590-1.20]). Similar risk reductions were present for the inhaled and systemic GCSs. A dose-response relationship was present. Our finding of an inverse relation between GCS consumption and new psychotic episodes may promote further research into inflammation in schizophrenia.

Original languageEnglish
Pages (from-to)288-290
Number of pages3
JournalJournal of Clinical Psychopharmacology
Issue number3
Publication statusPublished - Jun-2009


  • schizophrenia, psychosis, inflammation, glucocorticosteroids, SCHIZOPHRENIA, CELECOXIB, THERAPY

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