Biophysical Interactions of vaginal microorganisms

Younes, J. A., 2015, [Groningen]: University of Groningen. 172 p.

Research output: ThesisThesis fully internal (DIV)

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  • Title and contents

    Final publisher's version, 241 KB, PDF document

  • Chapter 1

    Final publisher's version, 690 KB, PDF document

  • Chapter 2

    Final publisher's version, 492 KB, PDF document

  • Chapter 3

    Final publisher's version, 529 KB, PDF document

  • Chapter 4

    Final publisher's version, 842 KB, PDF document

  • Chapter 5

    Final publisher's version, 826 KB, PDF document

  • Chapter 6

    Final publisher's version, 230 KB, PDF document

  • Appendices

    Final publisher's version, 231 KB, PDF document

  • Complete dissertation

    Final publisher's version, 2.87 MB, PDF document

  • Propositions

    Final publisher's version, 40.2 KB, PDF document

  • Jessica Anne Younes
Vaginal health has always been important, but current research is just starting to be able to explain why and how to maintain it. Unfortunately, vaginal infections are very common, hard to treat, and poorly understood. Infections caused by changes in the vaginal bacterial community can lead to serious health consequences for a woman and any children she may bear. Normal vaginal bacteria (generally Lactobacillus sp.) and probiotic bacteria show promising directions for prevention and therapy. This thesis looks at the importance of adhesion between vaginal bacteria (pathogens and lactobacilli) and between bacteria and vaginal cells to see how it affects circumstances commonly seen in vaginal infection (e.g. inflammation, biofilm formation, toxin production, etc). Adhesive lactobacilli bacteria are better able to reduce pathogen virulence, inflammation, and biofilm formation than non-adhesive ones. Pathogenic bacteria seem to stick more strongly to vaginal cells, but lactobacilli adhere better to the pathogens themselves, and perhaps this is one of the mechanisms by which they exert their beneficial influence. Adhesion is an important factor that should be further investigated among vaginal bacteria.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Mei, van der, Henny, Supervisor
  • Busscher, Henk, Supervisor
  • Reid, G, Supervisor, External person
  • Abee, Tjakko, Assessment committee, External person
  • Hoekstra, Dick, Assessment committee
  • Vrouwenvelder, J.S. (Hans), Assessment committee, External person
Award date6-May-2015
Place of Publication[Groningen]
Print ISBNs978-90-367-7842-8
Electronic ISBNs978-90-367-7841-1
Publication statusPublished - 2015

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