Advances of epigenetic editing

Gjaltema, R. A. F. & Rots, M. G., Aug-2020, In : Current Opinion in Chemical Biology. 57, p. 75-81 7 p.

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Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often with the aim of transcriptional reprogramming. Implementing clustered regularly interspaced short palindromic repeat-dCas9 greatly accelerated the advancement of epigenetic editing, yielding preclinical therapeutic successes using a variety of epigenetic enzymes. ,CRISPR/dCas9 Here, were review the current applications of these epigenetic editing tools in mammalians and shed light on biochemical improvements that facilitate versatile applications.

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalCurrent Opinion in Chemical Biology
Early online date29-Jun-2020
Publication statusPublished - Aug-2020

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