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A case of concomitant pulmonary tuberculosis and mucormycosis in an insulin-dependent diabetic patient

O, J. Z., LN, V. R., M, A. L., JD, U. Á., MA, M. R., GA, F. S. & J.D., M., 1-Aug-2019, In : Journal of Clinical Tuberculosis and Other Mycobacterial Diseases. 16, 6 p., 100105.

Research output: Contribution to journalArticleAcademicpeer-review

  • Jiménez Zarazúa O
  • Vélez Ramírez LN
  • Alcocer León M
  • Utrilla Álvarez JD
  • Martínez Rivera MA
  • Flores Saldaña GA
  • Mondragón J.D.

Conditions, where the patient's immune system is compromised are the main risk factor for mucormycosis. Approximately 23% of the world's population is estimated to have a latent Mycobacterium tuberculosis infection and more than 10 million new cases were estimated in 2017. Pulmonary mucormycosis and tuberculosis co-infections are very rare. We present the case of a 56-year-old insulin-dependent diabetic patient with a pulmonary mucormycosis and tuberculosis co-infection. While the patient did not suffer from ketoacidosis, she had poor glycemic control. A chest X-ray and a computed tomography showed nodular and cavitary lesions in both lungs. The patient was diagnosed through a biopsy of the bronchial mucosa and an RT-PCR for M. tuberculosis from bronchoalveolar lavage. The patient was treated with the recommended 4-drug regimen for TB (i.e. isoniazid, rifampin, pyrazinamide, and ethambutol); concurrently, amphotericin B deoxycholate was administered to treat the mucormycosis infection. Thirty days after initial hospital admission the patient underwent a lobectomy on the right lung. The case described here is only the sixth case reported in the literature of concomitant pulmonary tuberculosis and mucormycosis and the third case associated with a TB and mucormycosis co-infection involving an uncontrolled DM patient to survive.

Original languageEnglish
Article number100105
Number of pages6
JournalJournal of Clinical Tuberculosis and Other Mycobacterial Diseases
Volume16
Publication statusPublished - 1-Aug-2019

    Keywords

  • Diabetes, Immunosuppression, Pulmonary mucormycosis, Tuberculosis

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