Postal address:
A Deusinglaan
Gebouw 3226, ruimte 0601
Phone: +31 50 363 3338Fax: +31 50 363 7582

Research interests


Prof. Dr. Rainer Bischoff

Chair of the Department of Analytical Biochemistry (


Faculty of Mathematics and Natural Science, University of Groningen, the Netherlands        

Telephone: +31 50 363 3336



Field/ Discipline: Chemistry, Analytical
                         Biochemical Research Methods

Expertise:          Proteomics, Chromatography, Mass 
                         Spectrometry, Electrochemistry
                         Biopharmaceuticals, Biomarkers   


Rainer Bischoff started his career in protein-related research when joining the biotechnology company Transgene (Strasbourg, France) in 1987. He applied mass spectrometry to the characterization of recombinant proteins early on with a first paper appearing in 1990 using electrospray ionization for the analysis of alpha-1-antitrypsin and its variants. Rainer Bischoff continued his career at AstraZeneca R&D (Lund, Sweden) before joining the Faculty of Mathematics and Natural Sciences at the University of Groningen (The Netherlands) in 2001 as full professor of Analytical Biochemistry. Research interests of the Analytical Biochemistry Department focus on biomarker discovery and validation, bioinformatics (in collaboration with Prof. Horvatovich), the bioanalysis of biopharmaceutical proteins and the development of novel instrumental analytical techniques (e.g. based on the coupling of electrochemistry to mass spectrometry). The group uses state-of-the-art equipment for protein and peptide separation and identification mainly based on high-performance liquid chromatography coupled to mass spectrometry. Rainer Bischoff is responsible for the interfaculty mass spectrometry core facility housing currently 16 LC-MS/MS installations.

Rainer Bischoff served in a number of functions such as chairing the national Analytical Chemistry working group of the Dutch Scientific Research Organization (NWO) and currently being the Dutch representative of the Chromosome-Centric HPP program of HUPO.

Rainer Bischoff authored more than 200 peer-reviewed publications and book chapters and is inventor on 12 patents.

Google Scholar:

ISI Researcher ID:

  1. Surface-modified electrodes in the mimicry of oxidative drug metabolism

    Yuan, T., Permentier, H. & Bischoff, R. 1-Jul-2015 In : TrAC-Trends in Analytical Chemistry. 70, p. 50-57

    Research output: Contribution to journalArticle

  2. Integrated quantification and identification of aldehydes and ketones in biological samples

    Siegel, D., Meinema, A. C., Permentier, H., Hopfgartner, G. & Bischoff, R. 20-May-2014 In : Analytical Chemistry. 86, 10, p. 5089-100 12 p.

    Research output: Contribution to journalArticle

  3. A Panel of Regulated Proteins in Serum from Patients with Cervical Intraepithelial Neoplasia and Cervical Cancer

    Boichenko, A. P., Govorukhina, N., Klip, H. G., van der Zee, A. G. J., Guezel, C., Luider, T. M. & Bischoff, R. Nov-2014 In : Journal of Proteome Research. 13, 11, p. 4995-5007 13 p.

    Research output: Contribution to journalArticle

  4. Antibody-free LC-MS/MS quantification of rhTRAIL in human and mouse serum

    Wilffert, D., Reis, C. R., Hermans, J., Govorukhina, N., Tomar, T., de Jong, S., Quax, W. J., van de Merbel, N. C. & Bischoff, R. 19-Nov-2013 In : Analytical Chemistry. 85, 22, p. 10754-10760 7 p.

    Research output: Contribution to journalArticle

  5. Boron-Doped Diamond Electrodes for the Electrochemical Oxidation and Cleavage of Peptides

    Roeser, J., Alting, N. F. A., Permentier, H. P., Bruins, A. P. & Bischoff, R. 16-Jul-2013 In : Analytical Chemistry. 85, 14, p. 6626-6632 7 p.

    Research output: Contribution to journalArticle

  6. Minocycline Effects on the Cerebrospinal Fluid Proteome of Experimental Autoimmune Encephalomyelitis Rats

    Stoop, M. P., Rosenling, T., Attali, A., Meesters, R. J. W., Stingl, C., Dekker, L. J., van Aken, H., Suidgeest, E., Hintzen, R. Q., Tuinstra, T., van Gool, A., Luider, T. M. & Bischoff, R. 2012 In : Journal of Proteome Research. 11, 8, p. 4315-4325 11 p.

    Research output: Contribution to journalArticle

  7. The Impact of Delayed Storage on the Measured Proteome and Metabolome of Human Cerebrospinal Fluid

    Rosenling, T., Stoop, M. P., Smolinska, A., Muilwijk, B., Coulier, L., Shi, S., Dane, A., Christin, C., Suits, F., Horvatovich, P. L., Wijmenga, S. S., Buydens, L. M. C., Vreeken, R., Hankemeier, T., van Gool, A. J., Luider, T. M. & Bischoff, R. Dec-2011 In : Clinical Chemistry. 57, 12, p. 1703-1711 9 p.

    Research output: Contribution to journalArticle

  8. Physiology and pathophysiology of matrix metalloproteases

    Klein, T. & Bischoff, R. 2010 In : Amino Acids.

    Research output: Contribution to journalArticle

  9. Efficient and Selective Chemical Labeling of Electrochemically Generated Peptides Based on Spirolactone Chemistry

    Zhang, T., Niu, X., Yuan, T., Tessari, M., de Vries, M. P., Permentier, H. P. & Bischoff, R. 21-Jun-2016 In : Analytical Chemistry. 88, 12, p. 6465-6471 7 p.

    Research output: Contribution to journalArticle

  10. LC-MS/MS-based monitoring of in vivo protein biotransformation: quantitative determination of trastuzumab and its deamidation products in human plasma

    Bults, P., Bischoff, R., Bakker, H., Gietema, J. A. & van de Merbel, N. C. 11-Feb-2016 In : Analytical Chemistry. 88, 3, p. 1871-1877 7 p.

    Research output: Contribution to journalArticle

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Press / Media
  1. Bioanalysis Zone

    Rainer Bischoff


    1 media contribution

    Press/Media: Public Engagement Activities

  2. Elektrochemische enzymen

    Rainer Bischoff


    1 media contribution

    Press/Media: Research

View all (4) »

  1. 27th International Symposium on Pharmaceuticals and Biomedical Analysis

    Bischoff, R. (Chair)

    Activity: ScientificParticipation in conference

  2. Journal of Chromatography B (Journal)

    Bischoff, R. (Editor)

    Activity: ScientificEditorial activity

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