Research interests

Dr. Marjolijn N. Lub-de Hooge

is a Hospital Pharmacist and associate professor at the department of Clinical Pharmacy and Pharmacology, and at the department of Nuclear Medicine and Molecular Imaging of the University Medical Center Groningen. She obtained her PhD on pharmaceutical aspects and molecular imaging of new receptor targeted drugs.

Her research mainly focuses on molecular imaging to support and optimize treatment of cancer patients with novel (targeted and immuno) therapies. She is an expert in the development, evaluation and translation of new radiopharmaceuticals and optical tracers to the clinical setting. And she is also involved in the subsequent clinical application of these new tracers for drug development, and treatment optimization: visualization of presence of drug target (patient selection), drug biodistribution (pharmacokinetics, optimal dosing, target saturation) and tumor status during treatment (early predictive biomarker, pharmacodynamics).

 

 

Publications
  1. First-in-human PET imaging with the PD-L1 antibody Zr-89-atezolizumab

    Bensch, F., van der Veen, E., Jorritsma, A., Lub-de Hooge, M., Boellaard, R., Oosting, S., Schroder, C., Hiltermann, J., van der Wekken, A., Groen, H., Fine, B., McKnight, N., Bohorquez, S. S., Williams, S., Veronese, L., Mancao, C., Brouwers, A. H. & de Vries, E., Jul-2017, In : Cancer Research. 77, 2 p.

    Research output: Contribution to journalMeeting AbstractAcademic

  2. Zr-89-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer

    Bensch, F., van der Veen, E. L., Lub-de Hooge, M. N., Jorritsma-Smit, A., Boellaard, R., Kok, I. C., Oosting, S. F., Schroder, C. P., Hiltermann, T. J. N., van der Wekken, A. J., Groen, H. J. M., Kwee, T. C., Elias, S. G., Gietema, J. A., Bohorquez, S. S., de Crespigny, A., Williams, S-P., Mancao, C., Brouwers, A. H., Fine, B. M. & de Vries, E. G. E., Dec-2018, In : Nature Medicine. 24, 12, p. 1852-1858 7 p.

    Research output: Contribution to journalLetterAcademicpeer-review

  3. Integrating molecular nuclear imaging in clinical research to improve anticancer therapy

    de Vries, E. G. E., Kist de Ruijter, L., Lub-de Hooge, M. N., Dierckx, R. A., Elias, S. G. & Oosting, S. F., 27-Nov-2018, In : Nature Reviews Clinical Oncology. 15 p.

    Research output: Contribution to journalReview articleAcademicpeer-review

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