Research interests

During his routine TDM training he developed great interest into infectious diseases in critically ill patients. His research is focussed on the pharmacokinetics and pharmacodynamics of antimicrobial agents, in particular antifungal agents and anti-TB drugs. The aim is to optimize antimicrobial therapy based on PK/PD principles. The overall aim is to find a balance between efficacy and toxicity. Helpful tools are therapeutic drug monitoring, pharmacokinetic modeling, optimal sampling strategies. Also his more analytical oriented reasearch is focused on optimization of treatment by using alternative sampling strategies like dried blood spot sampling and oral fluid as alternative for plasma and serum.

Publications
  1. Cost-utility analysis of high-dose treatment for intermediate-susceptible, dose-dependent tuberculosis patients

    Zuur, M. A., van Asselt, A. D. I., van 't Boveneind-Vrubleuskaya, N., Aleksa, A., Postma, M. J. & Alffenaar, J. W. C. 1-Sep-2018 In : International Journal of Tuberculosis and Lung Disease. 22, 9, p. 991-999 9 p.

    Research output: Contribution to journalArticle

  2. Outcomes of patients with drug-resistant-tuberculosis treated with bedaquiline-containing regimens and undergoing adjunctive surgery

    Borisov, S. E., D'Ambrosio, L., Centis, R., Tiberi, S., Dheda, K., Alffenaar, J-W., Amale, R., Belilowski, E., Bruchfeld, J., Canneto, B., Denholm, J., Duarte, R., Esmail, A., Filippov, A., Forsman, L. D., Gaga, M., Ganatra, S., Igorevna, G. A., Mastrapa, B. L., Manfrin, V., Manga, S., Maryandyshev, A., Massard, G., Montaner, P. G., Mullerpattan, J., Palmero, D. J., Pontarelli, A., Papavasileiou, A., Pontali, E., Leyet, R. R., Spanevello, A., Udwadia, Z. F., Viggiani, P., Visca, D., Sotgiu, G. & Migliori, G. B. 7-Aug-2018 In : Journal of infection. 18 p.

    Research output: Contribution to journalArticle

  3. Linezolid pharmacokinetics in MDR-TB: A systematic review, meta-analysis and Monte Carlo simulation

    Millard, J., Pertinez, H., Bonnett, L., Hodel, E. M., Dartois, V., Johnson, J. L., Caws, M., Tiberi, S., Bolhuis, M., Alffenaar, J-W. C., Davies, G. & Sloan, D. J. Jul-2018 In : Journal of Antimicrobial Chemotherapy. 73, 7, p. 1755-1762 8 p.

    Research output: Contribution to journalReview article

  4. Invasive Candidiasis in the Elderly: Considerations for Drug Therapy

    Dekkers, B. G. J., Veringa, A., Marriott, D. J. E., Boonstra, J. M., van der Elst, K. C. M., Doukas, F. F., McLachlan, A. J. & Alffenaar, J-W. C. 26-Jul-2018 In : Drugs & Aging. 9 p.

    Research output: Contribution to journalArticle

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