Research interests

During his routine TDM training he developed great interest into infectious diseases in critically ill patients. His research is focussed on the pharmacokinetics and pharmacodynamics of antimicrobial agents, in particular antifungal agents and anti-TB drugs. The aim is to optimize antimicrobial therapy based on PK/PD principles. The overall aim is to find a balance between efficacy and toxicity. Helpful tools are therapeutic drug monitoring, pharmacokinetic modeling, optimal sampling strategies. Also his more analytical oriented reasearch is focused on optimization of treatment by using alternative sampling strategies like dried blood spot sampling and oral fluid as alternative for plasma and serum.

  1. Risk factors of multidrug-resistant tuberculosis: A global systematic review and meta-analysis

    Pradipta, I. S., Forsman, L. D., Bruchfeld, J., Hak, E. & Alffenaar, J-W. 16-Sep-2018 In : Journal of infection.

    Research output: Contribution to journalArticle

  2. Global TB Network: working together to eliminate tuberculosis

    Silva, D. R., Rendon, A., Alffenaar, J-W., Chakaya, J. M., Sotgiu, G., Esposito, S. & Migliori, G. B. 2018 In : Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia. p. 0

    Research output: Contribution to journalArticle

  3. Plasma concentrations of second-line antituberculosis drugs in relation to minimum inhibitory concentrations in multidrug-resistant tuberculosis patients in China: A study protocol of a prospective observational cohort study

    Davies Forsman, L., Niward, K., Hu, Y., Zheng, R., Zheng, X., Ke, R., Cai, W., Hong, C., Li, Y., Gao, Y., Werngren, J., Paues, J., Kuhlin, J., Simonsson, U. S. H., Eliasson, E., Alffenaar, J-W., Mansjö, M., Hoffner, S., Xu, B., Schön, T. & Bruchfeld, J. 2018 In : BMJ Open. 8, 9, 8 p., e023899

    Research output: Contribution to journalArticle

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