Research interests

I am a hematopathologist at the University Medical Center Groningen and a principal investigator in the SALL (stem cells, aging, leukemia and lymphoma) program of the CRCG (Cancer Research Center Groningen). My main research interest involves malignant lymphoma, in particular Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In my PhD thesis "Classical Hodgkin lymphoma: population based studies on HLA and EBV (2007)" I discovered that the HLA system is intricately involved in Hodgkin lymphoma susceptibility, pathogenesis and prognosis and published these findings in the Lancet and Journal of Clinical Oncology. I secured three Dutch Cancer Society grants to do functional follow-up studies on these findings. Fruitful international collaborations involve the Interlymph consortium on genome wide association studies, the Lymphoma group of the EORTC and various groups in the UK, Canada and the US. My areas of expertise are: immunology, tumor cell biology, association studies and molecular diagnostics in pathology.   

Publications
  1. Programmed cell death protein1 (PD1)-expression in the microenvironment of classical Hodgkin lymphoma at relapse after conventional chemotherapy and at relapse on anti-PD1 treatment

    Sasse, S., Reddemann, K., Diepstra, A., Borchmann, S., Oschlies, I., Schnitter, A., Engert, A., Borchmann, P. & Klapper, W. Jan-2019 In : Haematologica. 104, 1, p. e45-e46

    Research output: Contribution to journalArticle

  2. Mutational Evolution in Relapsed Diffuse Large B-Cell Lymphoma

    Nijland, M., Seitz, A., Terpstra, M., van Imhoff, G. W., Kluin, P. M., van Meerten, T., Atayar, Ç., van Kempen, L. C., Diepstra, A., Kok, K. & van den Berg, A. 20-Nov-2018 In : Cancers. 10, 11, 14 p., 459

    Research output: Contribution to journalArticle

  3. Prospective Isolation and Characterization of Genetically and Functionally Distinct AML Subclones

    de Boer, B., Prick, J., Pruis, M. G., Keane, P., Imperato, M. R., Jaques, J., Brouwers-Vos, A. Z., Hogeling, S. M., Woolthuis, C. M., Nijk, M. T., Diepstra, A., Wandinger, S., Versele, M., Attar, R. M., Cockerill, P. N., Huls, G., Vellenga, E., Mulder, A. B., Bonifer, C. & Schuringa, J. J. 8-Oct-2018 In : Cancer cell. 34, 4, p. 674-+ 24 p.

    Research output: Contribution to journalArticle

  4. MicroRNA High Throughput Loss-of-Function Screening Reveals an Oncogenic Role for miR-21-5p in Hodgkin Lymphoma

    Yuan, Y., Niu, F., Nolte, I. M., Koerts, J., de Jong, D., Rutgers, B., Osinga, J., Azkanaz, M., Terpstra, M., Bystrykh, L., Diepstra, A., Visser, L., Dzikiewicz-Krawczyk, A., Kok, K., Kluiver, J. & van den Berg, A. 2018 In : Cellular physiology and biochemistry. 49, 1, p. 144-159 16 p.

    Research output: Contribution to journalArticle

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Press / Media
  1. Een lab dat levens redt - a lab that saves lives

    Arjan Diepstra

    29/04/2016

    1 item of media coverage

    Press/Media: Public Engagement Activities

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Activities
  1. Ralf Küppers

    Diepstra, A. (Host)
    17-May-2018

    Activity: ScientificHosting a visitor

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Prizes
  1. Karl Musshoff Prize

    Arjan Diepstra (Recipient), 24-Oct-2016

    Prize

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