Research interests

I am a hematopathologist at the University Medical Center Groningen and a principal investigator in the SALL (stem cells, aging, leukemia and lymphoma) program of the CRCG (Cancer Research Center Groningen). My main research interest involves malignant lymphoma, in particular Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In my PhD thesis "Classical Hodgkin lymphoma: population based studies on HLA and EBV (2007)" I discovered that the HLA system is intricately involved in Hodgkin lymphoma susceptibility, pathogenesis and prognosis and published these findings in the Lancet and Journal of Clinical Oncology. I secured three Dutch Cancer Society grants to do functional follow-up studies on these findings. Fruitful international collaborations involve the Interlymph consortium on genome wide association studies, the Lymphoma group of the EORTC and various groups in the UK, Canada and the US. My areas of expertise are: immunology, tumor cell biology, association studies and molecular diagnostics in pathology.   

Publications
  1. Final Analysis of the Front-Line Phase III Randomized ACT-1 Trial in Younger Patients with Systemic Peripheral T-Cell Lymphoma Treated with CHOP Chemotherapy with or without Alemtuzumab and Consolidated By Autologous Hematopoietic Stem Cell Transplant

    d'Amore, F., Leppa, S., da Silva, M. G., Relander, T., Lauritzsen, G. F., Brown, P. D. N., Pezzutto, A., Doorduijn, J. K., Weidmann, E., van Gelder, M., Van Hoof, A., Christiansen, I., Fagerli, U. M., Hagberg, H., Lugtenburg, P. J., Walewski, J., Wu, K. L., Demuynck, H. M., Fijnheer, R., Christensen, J. H., Jankovska, M., Josefsson, P. L., Kluin-Nelemans, H., Mariz, J. M., Merup, M. A., Noesslinger, T., Van den Neste, E., Zijlstra, J. M., Hopfinger, G., Prochazka, V. I. T., Jantunen, E., Boudova, L., Cabecadas, J., Chott, A., Delabie, J. M. A., de Leval, L., Diepstra, A., Karjalainen-Lindsberg, M-L., Noergaard, P., Rosenwald, A., Rymkiewicz, G., Sundstrom, C., Truemper, L., Wulf, G., Chong, L., Bouska, A., Smith, L., Gisselbrecht, C., Ziepert, M., Loeffler, M., Liestol, K., Steidl, C., Gascoyne, R. D., Scott, D. W., Altmann, B., Iqbal, J., Chan, W. C. & Toldbod, H., 29-Nov-2018, In : Blood. 132, 6 p.

    Research output: Contribution to journalMeeting AbstractAcademic

  2. miR-24-3p Is Overexpressed in Hodgkin Lymphoma and Protects Hodgkin and Reed Sternberg Cells from Apoptosis (vol 187, pg 1343, 2017)

    Yuan, Y., Kluiver, J., Koerts, J., de Jong, D., Rutgers, B., Razak, F. R. A., Terpstra, M., Plaat, B. E., Nolte, I. M., Diepstra, A., Visser, L., Kok, K. & van den Berg, A., Feb-2019, In : American Journal of Pathology. 189, 2, p. 479-479 1 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Massive B-Cell Infiltration and Organization Into Artery Tertiary Lymphoid Organs in the Aorta of Large Vessel Giant Cell Arteritis

    Graver, J. C., Boots, A. M. H., Haacke, E. A., Diepstra, A., Brouwer, E. & Sandovici, M., 29-Jan-2019, In : Frontiers in Immunology. 10, p. 83 8 p., 83.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Programmed cell death protein1 (PD1)-expression in the microenvironment of classical Hodgkin lymphoma at relapse after conventional chemotherapy and at relapse on anti-PD1 treatment

    Sasse, S., Reddemann, K., Diepstra, A., Borchmann, S., Oschlies, I., Schnitter, A., Engert, A., Borchmann, P. & Klapper, W., Jan-2019, In : Haematologica. 104, 1, p. E45-E46 2 p.

    Research output: Contribution to journalEditorialAcademicpeer-review

  5. Mutational Evolution in Relapsed Diffuse Large B-Cell Lymphoma

    Nijland, M., Seitz, A., Terpstra, M., van Imhoff, G. W., Kluin, P. M., van Meerten, T., Atayar, Ç., van Kempen, L. C., Diepstra, A., Kok, K. & van den Berg, A., 20-Nov-2018, In : Cancers. 10, 11, 14 p., 459.

    Research output: Contribution to journalArticleAcademicpeer-review

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Press / Media
  1. Een lab dat levens redt - a lab that saves lives

    Arjan Diepstra

    29/04/2016

    1 item of media coverage

    Press/Media: Public Engagement ActivitiesPopular

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Activities
  1. Het Hodgkin lymfoom

    Arjan Diepstra (Speaker)
    6-Nov-2018

    Activity: Talk or presentationProfessional

  2. 13th Dutch Hematology Congress

    Arjan Diepstra (Chair)
    23-Jan-2019

    Activity: Participating in or organising an eventParticipation in conferenceAcademic

  3. 13th Dutch Hematology Congress

    Arjan Diepstra (Invited speaker)
    25-Jan-2019

    Activity: Participating in or organising an eventParticipation in conferenceAcademic

View all (9) »

Prizes
  1. Karl Musshoff Prize

    Arjan Diepstra (Recipient), 24-Oct-2016

    PrizeAcademic

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