Dataset

Description

In 1965 one of the first large epidemiological studies started in the Netherlands: the population study in Vlagtwedde and Vlaardingen. Over 8000 people took part. The cohort study was concluded in 1990, but the data from the databank still provide useful information in the research into the origin of lung diseases. For instance, follow-up research into mortality in this cohort has resulted in the discovery that people with a higher airway sensitivity have a greater chance of dying from COPD. Research is currently being conducted into genetic causes of reduced lung function in the Vlagtwedde/Vlaardingen cohort. Reduced lung function is a normal phenomenon of ageing, but in some people it is accelerated. This can result in bronchial problems and diseases like COPD. UMCG researchers have found that the ADAM33 gene is responsible for an accelerated reduction in lung function in the population as a whole and in patients with asthma and (severe) COPD. This gene can therefore be considered a general lung-ageing gene.
The database contains experimental data, biological samples, and DNA of approx. 8000 participants (male and female).
Date made available1990
PublisherUniversity of Groningen
Temporal coverage1965 - 1990
Geographical coverageThe Netherlands, Vlaardingen, Vlagtwedde
Access to the dataset Restricted
Contact researchdata@rug.nl

    Keywords on Datasets

  • biological samples, COPD, ADAM33, asthma, Longitudinal study, aging, VlaVla, Rudolf van der Lende, urn:miriam:icd:J44.9
Related Publications
  1. No convincing association between genetic markers and respiratory symptoms: results of a GWA study

    Zeng, X., Vonk, J. M., de Jong, K., Xu, X., Huo, X. & Boezen, H. M., 10-Jan-2017, In : Respiratory Research. 18, 1, 6 p., 11.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Genetic and Environmental Determinants of Respiratory Health

    Zeng, X., 2016, [Groningen]: University of Groningen. 234 p.

    Research output: ThesisThesis fully internal (DIV)Academic

  3. Genome-wide association study on the FEV1/FVC ratio in never-smokers identifies HHIP and FAM13A

    van der Plaat, D. A., de Jong, K., Lahousse, L., Faiz, A., Vonk, J. M., van Diemen, C. C., Nedeljkovic, I., Amin, N., Brusselle, G. G., Hofman, A., Brandsma, C-A., Bossé, Y., Sin, D. D., Nickle, D. C., van Duijn, C. M., Postma, D. S. & Boezen, H. M., Feb-2017, In : Journal of Allergy and Clinical Immunology. 139, 2, p. 533-540 8 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Lifetime Smoking History and Cause-Specific Mortality in a Cohort Study with 43 Years of Follow-Up

    Taghizadeh, N., Vonk, J. M. & Boezen, H. M., 7-Apr-2016, In : PLoS ONE. 11, 4, 18 p., e0153310.

    Research output: Contribution to journalArticleAcademicpeer-review

  5. Genome-wide interaction study of gene-by-occupational exposure and effects on FEV1 levels

    de Jong, K., Vonk, J. M., Timens, W., Bosse, Y., Sin, D. D., Hao, K., Kromhout, H., Vermeulen, R., Postma, D. S. & Boezen, H. M., Dec-2015, In : Journal of Allergy and Clinical Immunology. 136, 6, p. 1664-1672.e14 23 p.

    Research output: Contribution to journalArticleAcademicpeer-review

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ID: 61679879