Dataset

Datasets: Inhibition of Interleukin-6 Receptor in a Murine Model of Myocardial Ischemia-Reperfusion

Hartman, H. (Creator), Baudoin, I. (Creator), Groot, H. (Creator), de Kolk, K. W. V. (Creator), Boer, de, R. (Creator), Mateo Leach, I. (Creator), Vliegenthart, R. (Creator), Sillje, H. (Creator), Harst, van der, P. (Creator), University of Groningen, 18-Nov-2016

Dataset

Description

Interleukin-6 (IL-6) levels are upregulated in myocardial infarction. Recent data suggest a causal role of the IL-6 receptor (IL-6R) in coronary heart disease. We evaluated if IL-6R blockade by a monoclonal antibody (MR16-1) prevents the heart from adverse left ventricular remodeling in a mouse model of ischemia-reperfusion (I/R).
CJ57/BL6 mice underwent I/R injury (left coronary artery ligation for 45 minutes) or sham surgery, and thereafter received MR16-1 (2mg/mouse) 5 minutes before reperfusion and 0.5mg/mouse weekly during four weeks, or control IgG treatment. Cardiac Magnetic Resonance Imaging (CMR) and hemodynamic measurements were performed to determine cardiac function after four weeks.
Date made available18-Nov-2016
PublisherUniversity of Groningen
Access to the dataset Open
Contact researchdata@rug.nl

    Keywords on Datasets

  • Health, Cardiology, myocardial infarction, cytokine concentrations, Ischemia reperfusion model
Related Publications
  1. Inhibition of Interleukin-6 Receptor in a Murine Model of Myocardial Ischemia-Reperfusion

    Hartman, M. H. T., Vreeswijk-Baudoin, I., Groot, H. E., van de Kolk, K. W. A., de Boer, R. A., Leach, I. M., Vliegenthart, R., Sillje, H. H. W. & van der Harst, P., 9-Dec-2016, In : PLoS ONE. 11, 12, 11 p., e0167195.

    Research output: Contribution to journalArticleAcademicpeer-review

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ID: 71893469