Dataset

Dataset: Ovalbumin-containing core-shell implants suitable to obtain a delayed IgG1 antibody response in support of a biphasic pulsatile release profile in mice

Amssoms, K. (Creator), Born, P. (Creator), Beugeling, M. (Creator), De Clerck, B. (Creator), Van Gulck, E. (Creator), Hinrichs, W. (Creator), Frijlink, E. (Creator), Grasmeijer, N. (Creator), Kraus, G. (Creator), Sutmuller, R. (Creator), Simmen, K. (Creator), Baert, L. (Creator), University of Groningen, 17-Aug-2018

Dataset

  • Katie Amssoms (Creator)
  • Philip Born (Creator)
  • Max Beugeling (Creator)
  • Ben De Clerck (Creator)
  • Ellen Van Gulck (Creator)
  • Wouter Hinrichs (Creator)
  • Erik Frijlink (Creator)
  • Niels Grasmeijer (Creator)
  • Guenter Kraus (Creator)
  • Roger Sutmuller (Creator)
  • Kenny Simmen (Creator)
  • Lieven Baert (Creator)

Description

Vaccination is one of the most effective and efficient ways to control the spread of more than thirty infectious diseases.
In this study we investigated whether a core-shell based implant, containing ovalbumin as core material and poly(DL-lactic-co-glycolic acid) of various monomer ratios as shell material can be used to obtain such a booster release. An in vitro release study showed that the lag time after which the ovalbumin was released from the core-shell implant increased with increasing lactic to glycolic acid ratio of the polymer and ranged from 3–6 weeks. Fluorescence spectroscopy showed minimal differences between native ovalbumin and ovalbumin from core-shell implants that were incubated until just before the observed in vitro release. In addition, mice immunized with a subcutaneous inserted core-shell implant containing ovalbumin showed an ovalbumin-specific IgG1 antibody response after a lag time of 4 or 6–8 weeks.
Date made available17-Aug-2018
PublisherUniversity of Groningen
Access to the dataset Open
Contact researchdata@rug.nl

    Keywords on Datasets

  • biogradable polymer, biphasic pulsatile release, implant, poly(lactic-co-glycolic acid), prime-boost, single-injection, antigen, vaccine
Related Publications
  1. Ovalbumin-containing core-shell implants suitable to obtain a delayed IgG1 antibody response in support of a biphasic pulsatile release profile in mice

    Amssoms, K., Born, P. A., Beugeling, M., De Clerck, B., Van Gulck, E., Hinrichs, W. L. J., Frijlink, H. W., Grasmeijer, N., Kraus, G., Sutmuller, R., Simmen, K. & Baert, L., 30-Aug-2018, In : PLoS ONE. 13, 8, p. e0202961 14 p., 0202961.

    Research output: Contribution to journalArticleAcademicpeer-review

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ID: 82018600